ID   A0A0C4DFQ8_HUMAN        Unreviewed;       726 AA.
AC   A0A0C4DFQ8;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   05-DEC-2018, entry version 22.
DE   SubName: Full=Neutral ceramidase {ECO:0000313|Ensembl:ENSP00000329886};
GN   Name=ASAH2 {ECO:0000313|Ensembl:ENSP00000329886};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000329886, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000329886, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000329886}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2015) to UniProtKB.
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DR   EMBL; AL450382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   UniGene; Hs.512645; -.
DR   UniGene; Hs.659820; -.
DR   ProteinModelPortal; A0A0C4DFQ8; -.
DR   Ensembl; ENST00000329428; ENSP00000329886; ENSG00000188611.
DR   EuPathDB; HostDB:ENSG00000188611.14; -.
DR   HGNC; HGNC:18860; ASAH2.
DR   OpenTargets; ENSG00000188611; -.
DR   eggNOG; KOG2232; Eukaryota.
DR   eggNOG; ENOG410XQWE; LUCA.
DR   GeneTree; ENSGT00390000015792; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000188611; Expressed in 93 organ(s), highest expression level in intestine.
DR   ExpressionAtlas; A0A0C4DFQ8; baseline and differential.
DR   Gene3D; 2.60.40.2300; -; 1.
DR   InterPro; IPR006823; Ceramidase_alk.
DR   InterPro; IPR038445; NCDase_C_sf.
DR   InterPro; IPR031331; NEUT/ALK_ceramidase_C.
DR   InterPro; IPR031329; NEUT/ALK_ceramidase_N.
DR   PANTHER; PTHR12670; PTHR12670; 2.
DR   Pfam; PF04734; Ceramidase_alk; 2.
DR   Pfam; PF17048; Ceramidse_alk_C; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0C4DFQ8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    726       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002170019.
FT   DOMAIN       83    391       Ceramidase_alk.
FT                                {ECO:0000259|Pfam:PF04734}.
FT   DOMAIN      390    554       Ceramidase_alk.
FT                                {ECO:0000259|Pfam:PF04734}.
FT   DOMAIN      556    723       Ceramidse_alk_C.
FT                                {ECO:0000259|Pfam:PF17048}.
SQ   SEQUENCE   726 AA;  79461 MW;  F35E4C7B98E55AD6 CRC64;
     MSAITVALLS LLFITSGTIE NHKDLGGHFF STTQSPPATQ GSTAAQRSTA TQHSTATQSS
     TATQTSPVPL TPESPLFQNF SGYHIGVGRA DCTGQVADIN LMGYGKSGQN AQGILTRLYS
     RAFIMAEPDG SNRTVFVSID IGMVSQRLRL EVLNRLQSKY GSLYRRDNVI LSGTHTHSGP
     AGYFQYTVFV IASEGFSNQT FQHMVTGILK SIDIAHTNMK PGKIFINKGN VDGVQINRSP
     YSYLQNPQSE RARYSSNTDK EMIVLKMVDL NGDDLGLISW FAIHPVSMNN SNHLVNSDNV
     GYASYLLEQE KNKGYLPGQG PFVAAFASSN LGDVSPNILG PRCINTGESC DNANSTCPIG
     GPSMCIAKGP GQDMFDSTQI IGRAMYQRAK SKTCKPALGY SFAAGTIDGV GGLNFTQGKT
     EGDPFWDTIR DQILGKPSEE IKECHKPKPI LLHTGELSKP HPWHPDIVDV QIITLGSLAI
     TAIPGEFTTM SGRRLREAVQ AEFASHGMQN MTVVISGLCN VYTHYITTYE EYQAQRYEAA
     STIYGPHTLS AYIQLFRNLA KAIATDTVAN LSRGPEPPFF KQLIVPLIPS IVDRAPKGRT
     FGDVLQPAKP EYRVGEVAEV IFVGANPKNS VQNQTHQTFL TVEKYEATST SWQIVCNDAS
     WETRFYWHKG LLGLSNATVE WHIPDTAQPG IYRIRYFGHN RKQDILKPAV ILSFEGTSPA
     FEVVTI
//