ID   A0A0C4DFP6_HUMAN        Unreviewed;       637 AA.
AC   A0A0C4DFP6;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   16-JAN-2019, entry version 27.
DE   SubName: Full=Cartilage acidic protein 1 {ECO:0000313|Ensembl:ENSP00000310810};
GN   Name=CRTAC1 {ECO:0000313|Ensembl:ENSP00000310810};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000310810, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000310810, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000310810}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2015) to UniProtKB.
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DR   EMBL; AL139239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL358938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   UniGene; Hs.500736; -.
DR   ProteinModelPortal; A0A0C4DFP6; -.
DR   jPOST; A0A0C4DFP6; -.
DR   Ensembl; ENST00000309155; ENSP00000310810; ENSG00000095713.
DR   EuPathDB; HostDB:ENSG00000095713.13; -.
DR   HGNC; HGNC:14882; CRTAC1.
DR   OpenTargets; ENSG00000095713; -.
DR   eggNOG; ENOG410IHAW; Eukaryota.
DR   eggNOG; ENOG410ZVH2; LUCA.
DR   GeneTree; ENSGT00390000013726; -.
DR   ChiTaRS; CRTAC1; human.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000095713; Expressed in 177 organ(s), highest expression level in tendon.
DR   ExpressionAtlas; A0A0C4DFP6; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR027039; Crtac1.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR011519; UnbV_ASPIC.
DR   PANTHER; PTHR16026:SF4; PTHR16026:SF4; 1.
DR   Pfam; PF07645; EGF_CA; 1.
DR   Pfam; PF07593; UnbV_ASPIC; 1.
DR   SMART; SM00179; EGF_CA; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS01187; EGF_CA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00033343};
KW   EGF-like domain {ECO:0000256|SAAS:SAAS00032677};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A0C4DFP6,
KW   ECO:0000213|PeptideAtlas:A0A0C4DFP6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    637       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002178494.
FT   DOMAIN      551    598       EGF_CA. {ECO:0000259|SMART:SM00179}.
SQ   SEQUENCE   637 AA;  69707 MW;  42543412E0419D6E CRC64;
     MSRMLPFLLL LWFLPITEGS QRAEPMFTAV TNSVLPPDYD SNPTQLNYGV AVTDVDHDGD
     FEIVVAGYNG PNLVLKYDRA QKRLVNIAVD ERSSPYYALR DRQGNAIGVT ACDIDGDGRE
     EIYFLNTNNA FSGVATYTDK LFKFRNNRWE DILSDEVNVA RGVASLFAGR SVACVDRKGS
     GRYSIYIANY AYGNVGPDAL IEMDPEASDL SRGILALRDV AAEAGVSKYT GGRGVSVGPI
     LSSSASDIFC DNENGPNFLF HNRGDGTFVD AAASAGVDDP HQHGRGVALA DFNRDGKVDI
     VYGNWNGPHR LYLQMSTHGK VRFRDIASPK FSMPSPVRTV ITADFDNDQE LEIFFNNIAY
     RSSSANRLFR VIRREHGDPL IEELNPGDAL EPEGRGTGGV VTDFDGDGML DLILSHGESM
     AQPLSVFRGN QGFNNNWLRV VPRTRFGAFA RGAKVVLYTK KSGAHLRIID GGSGYLCEME
     PVAHFGLGKD EASSVEVTWP DGKMVSRNVA SGEMNSVLEI LYPRDEDTLQ DPAPLECGQG
     FSQQENGHCM DTNECIQFPF VCPRDKPVCV NTYGSYRCRT NKKCSRGYEP NEDGTACVAQ
     VAFLGGYSSA ASRISEPLSR ASYLSLGLGL CLQLYAL
//