ID   A0A0B4J2E2_HUMAN        Unreviewed;       113 AA.
AC   A0A0B4J2E2;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   13-FEB-2019, entry version 35.
DE   RecName: Full=C-C motif chemokine {ECO:0000256|RuleBase:RU361150};
GN   Name=CCL15-CCL14 {ECO:0000313|Ensembl:ENSP00000481402};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000481402, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000481402, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000481402}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361150}.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000256|RuleBase:RU361150, ECO:0000256|SAAS:SAAS00582068}.
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DR   EMBL; AC244100; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_116741.2; NM_032965.5.
DR   UniGene; Hs.272493; -.
DR   SMR; A0A0B4J2E2; -.
DR   BioMuta; CCL15-CCL14; -.
DR   PeptideAtlas; A0A0B4J2E2; -.
DR   PRIDE; A0A0B4J2E2; -.
DR   Ensembl; ENST00000610751; ENSP00000481940; ENSG00000275688.
DR   Ensembl; ENST00000616694; ENSP00000481402; ENSG00000275688.
DR   GeneID; 6359; -.
DR   KEGG; hsa:6359; -.
DR   CTD; 6359; -.
DR   EuPathDB; HostDB:ENSG00000275688.4; -.
DR   GeneCards; CCL15-CCL14; -.
DR   HGNC; HGNC:44436; CCL15-CCL14.
DR   eggNOG; ENOG410J4DG; Eukaryota.
DR   eggNOG; ENOG4111C2C; LUCA.
DR   GeneTree; ENSGT00940000153198; -.
DR   KO; K05511; -.
DR   OMA; CCISYIS; -.
DR   OrthoDB; 1575018at2759; -.
DR   ChiTaRS; CCL15-CCL14; human.
DR   GenomeRNAi; 6359; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000275688; Expressed in 82 organ(s), highest expression level in right lobe of liver.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   InterPro; IPR030592; CCL15.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   PANTHER; PTHR12015:SF76; PTHR12015:SF76; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis {ECO:0000256|RuleBase:RU361150};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Cytokine {ECO:0000256|RuleBase:RU361150,
KW   ECO:0000256|SAAS:SAAS00582046};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|RuleBase:RU361150};
KW   Signal {ECO:0000256|RuleBase:RU361150}.
FT   SIGNAL        1     21       {ECO:0000256|RuleBase:RU361150}.
FT   CHAIN        22    113       C-C motif chemokine.
FT                                {ECO:0000256|RuleBase:RU361150}.
FT                                /FTId=PRO_5013980090.
FT   DOMAIN       50    108       SCY. {ECO:0000259|SMART:SM00199}.
SQ   SEQUENCE   113 AA;  12236 MW;  0BBC31FB696E16C9 CRC64;
     MKVSVAALSC LMLVAVLGSQ AQFTNDAETE LMMSKLPLEN PVVLNSFHFA ADCCTSYISQ
     SIPCSLMKSY FETSSECSKP GVIFLTKKGR QVCAKPSGPG VQDCMKKLKP YSI
//