ID   A0A0B4J299_HUMAN        Unreviewed;       434 AA.
AC   A0A0B4J299;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   16-JAN-2019, entry version 23.
DE   SubName: Full=Serine/threonine-protein kinase WNK1 {ECO:0000313|Ensembl:ENSP00000460651};
GN   Name=WNK1 {ECO:0000313|Ensembl:ENSP00000460651};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000460651, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000460651, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RG   Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA   Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D.,
RA   Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA   Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA   Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA   Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V.,
RA   Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J.,
RA   Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA   Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA   Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA   Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA   Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA   Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA   Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA   Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA   Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA   Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA   Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA   Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA   Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA   Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA   Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA   Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA   Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA   Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA   Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA   Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA   Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA   Kucherlapati R., Weinstock G., Gibbs R.A., null.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000460651}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2015) to UniProtKB.
CC   -!- INTERACTION:
CC       Q13643:FHL3; NbExp=5; IntAct=EBI-10230525, EBI-741101;
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DR   EMBL; AC004765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC004803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   UniGene; Hs.744906; -.
DR   ProteinModelPortal; A0A0B4J299; -.
DR   IntAct; A0A0B4J299; 1.
DR   jPOST; A0A0B4J299; -.
DR   PeptideAtlas; A0A0B4J299; -.
DR   Ensembl; ENST00000574564; ENSP00000460651; ENSG00000060237.
DR   EuPathDB; HostDB:ENSG00000060237.16; -.
DR   HGNC; HGNC:14540; WNK1.
DR   OpenTargets; ENSG00000060237; -.
DR   GeneTree; ENSGT00940000155474; -.
DR   ChiTaRS; WNK1; human.
DR   Proteomes; UP000005640; Chromosome 12.
DR   Bgee; ENSG00000060237; Expressed in 240 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; A0A0B4J299; baseline and differential.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0B4J299};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    434       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002107036.
SQ   SEQUENCE   434 AA;  47053 MW;  ECC18635C08CE13C CRC64;
     MYELLVLFML IQPQSMAHPC GGTPTYPESQ IFFPTIHERP VSFSPPPTCP PKVAISQRRK
     STSFLEAQTH HFQPLLRTVG QSLLPPGGSP TNWTPEAVVM LGTTASRVTG ESCEIQVHPM
     FEPSQVYSDY RPGLVLPEEA HYFIPQEAVY VAGVHYQARV AEQYEGIPYN SSVLSSPMKQ
     IPEQKPVQGG PTSSSVFEFP SGQAFLVGHL QNLRLDSGLG PGSPLSSISA PISTDATRLK
     FHPVFVPHSA PAVLTHNNES RSNCVFEFHV HTPSSSSGEG GGILPQRVYR NRQVAVDLNQ
     EELPPQSVGL HGYLQPVTEE KHNYHAPELT VSVVEPIGQN WPIGSPEYSS DSSQITSSDP
     SDFQSPPPTG GAAAPFGSDV SMPFIHLPQT VLQESPLFFC FPQGTTSQQV LTASFSSGGS
     ALHPQVIGKL PQLF
//