ID   A0A0B4J205_HUMAN        Unreviewed;       238 AA.
AC   A0A0B4J205;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   05-DEC-2018, entry version 24.
DE   SubName: Full=5-hydroxytryptamine receptor 3A {ECO:0000313|Ensembl:ENSP00000423653};
GN   Name=HTR3A {ECO:0000313|Ensembl:ENSP00000423653};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000423653, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000423653, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000423653}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687}.
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DR   EMBL; AP000908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   UniGene; Hs.413899; -.
DR   ProteinModelPortal; A0A0B4J205; -.
DR   SMR; A0A0B4J205; -.
DR   STRING; 9606.ENSP00000347754; -.
DR   PaxDb; A0A0B4J205; -.
DR   Ensembl; ENST00000510849; ENSP00000423653; ENSG00000166736.
DR   EuPathDB; HostDB:ENSG00000166736.11; -.
DR   HGNC; HGNC:5297; HTR3A.
DR   OpenTargets; ENSG00000166736; -.
DR   eggNOG; KOG3645; Eukaryota.
DR   eggNOG; ENOG410XQGR; LUCA.
DR   GeneTree; ENSGT00940000157705; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000166736; Expressed in 73 organ(s), highest expression level in islet of Langerhans.
DR   ExpressionAtlas; A0A0B4J205; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:InterPro.
DR   GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   PRINTS; PR00254; NICOTINICR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Ion channel {ECO:0000256|RuleBase:RU000687};
KW   Ion transport {ECO:0000256|RuleBase:RU000687};
KW   Membrane {ECO:0000256|SAAS:SAAS00032470};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00032470};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00032470};
KW   Transport {ECO:0000256|RuleBase:RU000687}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    238       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002094082.
FT   DOMAIN       36    181       Neur_chan_LBD.
FT                                {ECO:0000259|Pfam:PF02931}.
SQ   SEQUENCE   238 AA;  27397 MW;  0FA5DF31482B17F9 CRC64;
     MLLWVQQALL ALLLPTLLAQ GEARRSRNTT RPALLRLSDY LLTNYRKGVR PVRDWRKPTT
     VSIDVIVYAI LNVDEKNQVL TTYIWYRQYW TDEFLQWNPE DFDNITKLSI PTDSIWVPDI
     LINEFVDVGK SPNIPYVYIR HQGEVQNYKP LQVVTACSLD IYNFPFDVQN CSLTFTSWLH
     TSGHPPAAPL LCGQPATAQH LPHGHGHRGL LPAPQQWREG LFQDYTPPGL LGLPDHRF
//