ID   A0A0B4J1R0_HUMAN        Unreviewed;       160 AA.
AC   A0A0B4J1R0;
DT   04-MAR-2015, integrated into UniProtKB/TrEMBL.
DT   04-MAR-2015, sequence version 1.
DT   13-FEB-2019, entry version 28.
DE   SubName: Full=Chorionic somatomammotropin hormone-like 1 {ECO:0000313|Ensembl:ENSP00000259003};
GN   Name=CSHL1 {ECO:0000313|Ensembl:ENSP00000259003};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000259003, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000259003, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000259003}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU003618,
CC       ECO:0000256|SAAS:SAAS00687159}.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000256|RuleBase:RU003618, ECO:0000256|SAAS:SAAS00680088}.
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DR   EMBL; AC127029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001307997.1; NM_001321068.1.
DR   UniGene; Hs.654390; -.
DR   UniGene; Hs.655225; -.
DR   ProteinModelPortal; A0A0B4J1R0; -.
DR   SMR; A0A0B4J1R0; -.
DR   jPOST; A0A0B4J1R0; -.
DR   PeptideAtlas; A0A0B4J1R0; -.
DR   Ensembl; ENST00000259003; ENSP00000259003; ENSG00000204414.
DR   GeneID; 1444; -.
DR   CTD; 1444; -.
DR   EuPathDB; HostDB:ENSG00000204414.11; -.
DR   HGNC; HGNC:2442; CSHL1.
DR   OpenTargets; ENSG00000204414; -.
DR   eggNOG; ENOG410IFR6; Eukaryota.
DR   eggNOG; ENOG4111HU8; LUCA.
DR   GeneTree; ENSGT00730000111012; -.
DR   OrthoDB; 1190548at2759; -.
DR   ChiTaRS; CSHL1; human.
DR   GenomeRNAi; 1444; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000204414; Expressed in 15 organ(s), highest expression level in placenta.
DR   ExpressionAtlas; A0A0B4J1R0; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 2.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00835087};
KW   Hormone {ECO:0000256|RuleBase:RU003618};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00119356};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    160       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002092588.
SQ   SEQUENCE   160 AA;  18235 MW;  C2AC558E00594113 CRC64;
     MAAGSRTSLL LAFALLCLPW LQEADSIPTS SNMEETQQKS NLELLHISLL LIESRLEPVR
     FLRSTFTNNL VYDTSDSDDY HLLKDLEEGI QMLMGRLEDG SHLTGQTLKQ TYSKFDTNSH
     NHDALLKNYG LLHCFRKDMD KVETFLRMVQ CRSVEGSCGF
//