ID   A0A0A6YYL5_HUMAN        Unreviewed;       112 AA.
AC   A0A0A6YYL5;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   16-JAN-2019, entry version 30.
DE   RecName: Full=FXYD domain-containing ion transport regulator {ECO:0000256|RuleBase:RU364131};
GN   Name=FXYD6-FXYD2 {ECO:0000313|Ensembl:ENSP00000463024};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000463024, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000463024, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000463024}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (DEC-2014) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the FXYD family.
CC       {ECO:0000256|RuleBase:RU364131}.
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DR   EMBL; AP000757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001230527.1; NM_001243598.2.
DR   UniGene; Hs.744850; -.
DR   ProteinModelPortal; A0A0A6YYL5; -.
DR   SMR; A0A0A6YYL5; -.
DR   BioMuta; FXYD6-FXYD2; -.
DR   PaxDb; A0A0A6YYL5; -.
DR   PRIDE; A0A0A6YYL5; -.
DR   Ensembl; ENST00000532984; ENSP00000463024; ENSG00000255245.
DR   GeneID; 100533181; -.
DR   CTD; 100533181; -.
DR   EuPathDB; HostDB:ENSG00000255245.4; -.
DR   GeneCards; FXYD6-FXYD2; -.
DR   HGNC; HGNC:39978; FXYD6-FXYD2.
DR   OpenTargets; ENSG00000255245; -.
DR   ChiTaRS; FXYD6-FXYD2; human.
DR   GenomeRNAi; 100533181; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000255245; Expressed in 76 organ(s), highest expression level in adult mammalian kidney.
DR   ExpressionAtlas; A0A0A6YYL5; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0043269; P:regulation of ion transport; IEA:InterPro.
DR   InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR   Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
DR   ProDom; PD005989; PD005989; 1.
DR   PROSITE; PS01310; FXYD; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Ion transport {ECO:0000256|RuleBase:RU364131};
KW   Membrane {ECO:0000256|RuleBase:RU364131};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU364131};
KW   Transmembrane {ECO:0000256|RuleBase:RU364131};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU364131};
KW   Transport {ECO:0000256|RuleBase:RU364131}.
FT   SIGNAL        1     18       {ECO:0000256|RuleBase:RU364131}.
FT   CHAIN        19    112       FXYD domain-containing ion transport
FT                                regulator.
FT                                {ECO:0000256|RuleBase:RU364131}.
FT                                /FTId=PRO_5011332577.
FT   TRANSMEM     36     57       Helical. {ECO:0000256|RuleBase:RU364131}.
SQ   SEQUENCE   112 AA;  12769 MW;  8DA3A17AA5C551D1 CRC64;
     MELVLVFLCS LLAPMVLASA AEKEKEMDPF HYDYQTLRIG GLVFAVVLFS VGILLILRPQ
     EMRKPRWRTS SPPMQQSPRK QRTEVQPSGG RRQPQGGRGP VLLWQKIPLW GQ
//