ID A0A0A6YYF2_HUMAN Unreviewed; 1724 AA. AC A0A0A6YYF2; DT 04-FEB-2015, integrated into UniProtKB/TrEMBL. DT 04-FEB-2015, sequence version 1. DT 16-JAN-2019, entry version 39. DE SubName: Full=HCG1811249, isoform CRA_e {ECO:0000313|EMBL:EAX01167.1}; DE SubName: Full=Laminin subunit alpha-3 {ECO:0000313|Ensembl:ENSP00000269217}; GN Name=LAMA3 {ECO:0000313|Ensembl:ENSP00000269217}; GN ORFNames=hCG_1811249 {ECO:0000313|EMBL:EAX01167.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000269217, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|EMBL:EAX01167.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11181995; DOI=10.1126/science.1058040; RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., RA Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., RA Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G., RA Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., RA Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., RA Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., RA Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., RA Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., RA Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., RA Brandon R., Cargill M., Chandramouliswaran I., Charlab R., RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., RA Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., RA Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., RA Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., RA Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., RA Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., RA Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., RA Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., RA Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., RA Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., RA Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., RA Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., RA Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., RA Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., RA Kline L., Koduru S., Love A., Mann F., May D., McCawley S., RA McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., RA Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., RA Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., RA Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., RA Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., RA Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., RA Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., RA Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., RA Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., RA Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., RA Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., RA Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., RA Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., RA Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., RA McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., RA Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.; RT "The sequence of the human genome."; RL Science 291:1304-1351(2001). RN [2] {ECO:0000313|Ensembl:ENSP00000269217, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16177791; DOI=10.1038/nature03983; RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., RA Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., RA FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., RA Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R., RA Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., RA Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., RA Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., RA O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A., RA Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., RA Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., RA Lander E.S.; RT "DNA sequence and analysis of human chromosome 18."; RL Nature 437:551-555(2005). RN [3] {ECO:0000313|EMBL:EAX01167.1} RP NUCLEOTIDE SEQUENCE. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] {ECO:0000313|Ensembl:ENSP00000269217} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2014) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC010754; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC067796; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC090366; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456351; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471088; EAX01167.1; -; Genomic_DNA. DR RefSeq; NP_000218.3; NM_000227.4. DR UniGene; Hs.436367; -. DR SMR; A0A0A6YYF2; -. DR jPOST; A0A0A6YYF2; -. DR PeptideAtlas; A0A0A6YYF2; -. DR PRIDE; A0A0A6YYF2; -. DR Ensembl; ENST00000269217; ENSP00000269217; ENSG00000053747. DR GeneID; 3909; -. DR CTD; 3909; -. DR EuPathDB; HostDB:ENSG00000053747.15; -. DR HGNC; HGNC:6483; LAMA3. DR OpenTargets; ENSG00000053747; -. DR eggNOG; KOG1836; Eukaryota. DR eggNOG; ENOG410XRDC; LUCA. DR GeneTree; ENSGT00940000155638; -. DR OrthoDB; 2342at2759; -. DR ChiTaRS; LAMA3; human. DR GenomeRNAi; 3909; -. DR Proteomes; UP000005640; Chromosome 18. DR Bgee; ENSG00000053747; Expressed in 173 organ(s), highest expression level in ectocervix. DR ExpressionAtlas; A0A0A6YYF2; baseline and differential. DR GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA. DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro. DR GO; GO:0007155; P:cell adhesion; IEA:InterPro. DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro. DR GO; GO:0030334; P:regulation of cell migration; IEA:InterPro. DR GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR009254; Laminin_aI. DR InterPro; IPR010307; Laminin_dom_II. DR InterPro; IPR002049; Laminin_EGF. DR InterPro; IPR001791; Laminin_G. DR Pfam; PF00053; Laminin_EGF; 2. DR Pfam; PF02210; Laminin_G_2; 5. DR Pfam; PF06008; Laminin_I; 1. DR Pfam; PF06009; Laminin_II; 1. DR SMART; SM00180; EGF_Lam; 2. DR SMART; SM00282; LamG; 5. DR SUPFAM; SSF49899; SSF49899; 5. DR PROSITE; PS01248; EGF_LAM_1; 1. DR PROSITE; PS50027; EGF_LAM_2; 2. DR PROSITE; PS50025; LAM_G_DOMAIN; 5. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00460, KW ECO:0000256|SAAS:SAAS00966286}; KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460}; KW Proteomics identification {ECO:0000213|EPD:A0A0A6YYF2, KW ECO:0000213|MaxQB:A0A0A6YYF2, ECO:0000213|PeptideAtlas:A0A0A6YYF2}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 1724 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014017126. FT DOMAIN 78 124 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 125 177 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 781 982 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 989 1151 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 1158 1318 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 1377 1541 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 1548 1721 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT COILED 244 327 {ECO:0000256|SAM:Coils}. FT COILED 412 453 {ECO:0000256|SAM:Coils}. FT COILED 489 523 {ECO:0000256|SAM:Coils}. FT COILED 526 560 {ECO:0000256|SAM:Coils}. FT COILED 716 736 {ECO:0000256|SAM:Coils}. FT COILED 754 774 {ECO:0000256|SAM:Coils}. FT DISULFID 97 106 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 125 137 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 148 157 {ECO:0000256|PROSITE-ProRule:PRU00460}. SQ SEQUENCE 1724 AA; 190461 MW; F477C72D6661B8C8 CRC64; MPPAVRRSAC SMGWLWIFGA ALGQCLGYSS QQQRVPFLQP PGQSQLQASY VEFRPSQGCS PGYYRDHKGL YTGRCVPCNC NGHSNQCQDG SGICVNCQHN TAGEHCERCQ EGYYGNAVHG SCRACPCPHT NSFATGCVVN GGDVRCSCKA GYTGTQCERC APGYFGNPQK FGGSCQPCSC NSNGQLGSCH PLTGDCINQE PKDSSPAEEC DDCDSCVMTL LNDLATMGEQ LRLVKSQLQG LSASAGLLEQ MRHMETQAKD LRNQLLNYRS AISNHGSKIE GLERELTDLN QEFETLQEKA QVNSRKAQTL NNNVNRATQS AKELDVKIKN VIRNVHILLK QISGTDGEGN NVPSGDFSRE WAEAQRMMRE LRNRNFGKHL REAEADKRES QLLLNRIRTW QKTHQGENNG LANSIRDSLN EYEAKLSDLR ARLQEAAAQA KQANGLNQEN ERALGAIQRQ VKEINSLQSD FTKYLTTADS SLLQTNIALQ LMEKSQKEYE KLAASLNEAR QELSDKVREL SRSAGKTSLV EEAEKHARSL QELAKQLEEI KRNASGDELV RCAVDAATAY ENILNAIKAA EDAANRAASA SESALQTVIK EDLPRKAKTL SSNSDKLLNE AKMTQKKLKQ EVSPALNNLQ QTLNIVTVQK EVIDTNLTTL RDGLHGIQRG DIDAMISSAK SMVRKANDIT DEVLDGLNPI QTDVERIKDT YGRTQNEDFK KALTDADNSV NKLTNKLPDL WRKIESINQQ LLPLGNISDN MDRIRELIQQ ARDAASKVAV PMRFNGKSGV EVRLPNDLED LKGYTSLSLF LQRPNSRENG GTENMFVMYL GNKDASRDYI GMAVVDGQLT CVYNLGDREA ELQVDQILTK SETKEAVMDR VKFQRIYQFA RLNYTKGATS SKPETPGVYD MDGRNSNTLL NLDPENVVFY VGGYPPDFKL PSRLSFPPYK GCIELDDLNE NVLSLYNFKK TFNLNTTEVE PCRRRKEESD KNYFEGTGYA RVPTQPHAPI PTFGQTIQTT VDRGLLFFAE NGDRFISLNI EDGKLMVRYK LNSELPKERG VGDAINNGRD HSIQIKIGKL QKRMWINVDV QNTIIDGEVF DFSTYYLGGI PIAIRERFNI STPAFRGCMK NLKKTSGVVR LNDTVGVTKK CSEDWKLVRS ASFSRGGQLS FTDLGLPPTD HLQASFGFQT FQPSGILLDH QTWTRNLQVT LEDGYIELST SDSGGPIFKS PQTYMDGLLH YVSVISDNSG LRLLIDDQLL RNSKRLKHIS SSRQSLRLGG SNFEGCISNV FVQRLSLSPE VLDLTSNSLK RDVSLGGCSL NKPPFLMLLK GSTRFNKTKT FRINQLLQDT PVASPRSVKV WQDACSPLPK TQANHGALQF GDIPTSHLLF KLPQELLKPR SQFAVDMQTT SSRGLVFHTG TKNSFMALYL SKGRLVFALG TDGKKLRIKS KEKCNDGKWH TVVFGHDGEK GRLVVDGLRA REGSLPGNST ISIRAPVYLG SPPSGKPKSL PTNSFVGCLK NFQLDSKPLY TPSSSFGVSS CLGGPLEKGI YFSEEGGHVV LAHSVLLGPE FKLVFSIRPR SLTGILIHIG SQPGKHLCVY LEAGKVTASM DSGAGGTSTS VTPKQSLCDG QWHSVAVTIK QHILHLELDT DSSYTAGQIP FPPASTQEPL HLGGAPANLT TLRIPVWKSF FGCLRNIHVN HIPVPVTEAL EVQGPVSLNG CPDQ //