ID   A0A0A6YYA0_HUMAN        Unreviewed;       188 AA.
AC   A0A0A6YYA0;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   16-JAN-2019, entry version 31.
DE   SubName: Full=Protein TMED7-TICAM2 {ECO:0000313|Ensembl:ENSP00000333650};
GN   Name=TMED7-TICAM2 {ECO:0000313|Ensembl:ENSP00000333650};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000333650, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000333650, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000333650}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (DEC-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003827};
CC       Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU003827}.
CC   -!- SIMILARITY: Belongs to the EMP24/GP25L family.
CC       {ECO:0000256|RuleBase:RU003827, ECO:0000256|SAAS:SAAS00561910}.
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DR   EMBL; AC010226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001157941.1; NM_001164469.3.
DR   UniGene; Hs.642817; -.
DR   UniGene; Hs.718838; -.
DR   ProteinModelPortal; A0A0A6YYA0; -.
DR   SMR; A0A0A6YYA0; -.
DR   BioMuta; TMED7-TICAM2; -.
DR   EPD; A0A0A6YYA0; -.
DR   jPOST; A0A0A6YYA0; -.
DR   PRIDE; A0A0A6YYA0; -.
DR   Ensembl; ENST00000333314; ENSP00000333650; ENSG00000251201.
DR   GeneID; 100302736; -.
DR   KEGG; hsa:100302736; -.
DR   CTD; 100302736; -.
DR   EuPathDB; HostDB:ENSG00000251201.8; -.
DR   GeneCards; TMED7-TICAM2; -.
DR   HGNC; HGNC:33945; TMED7-TICAM2.
DR   OpenTargets; ENSG00000251201; -.
DR   eggNOG; KOG1693; Eukaryota.
DR   eggNOG; ENOG4111JPD; LUCA.
DR   ChiTaRS; TMED7-TICAM2; human.
DR   GenomeRNAi; 100302736; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000251201; Expressed in 89 organ(s), highest expression level in liver.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   InterPro; IPR009038; GOLD_dom.
DR   InterPro; IPR036598; GOLD_dom_sf.
DR   InterPro; IPR015718; TMED7.
DR   InterPro; IPR015720; TMP21-related.
DR   PANTHER; PTHR22811; PTHR22811; 1.
DR   PANTHER; PTHR22811:SF49; PTHR22811:SF49; 1.
DR   Pfam; PF01105; EMP24_GP25L; 1.
DR   SMART; SM01190; EMP24_GP25L; 1.
DR   SUPFAM; SSF101576; SSF101576; 1.
DR   PROSITE; PS50866; GOLD; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00561904};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00561904};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00561904}.
FT   SIGNAL        1     34       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        35    188       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002034149.
FT   DOMAIN       46    128       GOLD. {ECO:0000259|PROSITE:PS50866}.
SQ   SEQUENCE   188 AA;  21233 MW;  15A10CC4BD553DB3 CRC64;
     MPRPGSAQRW AAVAGRWGCR LLALLLLVPG PGGASEITFE LPDNAKQCFY EDIAQGTKCT
     LEFQVITGGH YDVDCRLEDP DGKVLYKEMK KQYDSFTFTA SKNGTYKFCF SNEFSTFTHK
     TVYFDFQVGE DPPLFPSENR VSALTQMESA CVSIHEALKS VIDYQTHFRL REAQGRSRAE
     DLNTRVAY
//