ID A0A0A0MTS5_HUMAN Unreviewed; 1668 AA. AC A0A0A0MTS5; DT 07-JAN-2015, integrated into UniProtKB/TrEMBL. DT 07-JAN-2015, sequence version 1. DT 16-JAN-2019, entry version 39. DE SubName: Full=HCG1811249, isoform CRA_f {ECO:0000313|EMBL:EAX01168.1}; DE SubName: Full=Laminin subunit alpha-3 {ECO:0000313|Ensembl:ENSP00000466557}; GN Name=LAMA3 {ECO:0000313|Ensembl:ENSP00000466557}; GN ORFNames=hCG_1811249 {ECO:0000313|EMBL:EAX01168.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000466557, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|EMBL:EAX01168.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11181995; DOI=10.1126/science.1058040; RA Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., RA Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., RA Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., RA Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G., RA Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., RA Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., RA Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., RA Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., RA Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., RA Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., RA Brandon R., Cargill M., Chandramouliswaran I., Charlab R., RA Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., RA Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., RA Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., RA Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., RA Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., RA Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., RA Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., RA Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., RA Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., RA Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., RA Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., RA Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., RA Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., RA Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., RA Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., RA Kline L., Koduru S., Love A., Mann F., May D., McCawley S., RA McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., RA Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., RA Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., RA Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., RA Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., RA Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., RA Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., RA Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., RA Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., RA Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., RA Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., RA Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., RA Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., RA Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., RA Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., RA Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., RA McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., RA Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., RA Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., RA Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.; RT "The sequence of the human genome."; RL Science 291:1304-1351(2001). RN [2] {ECO:0000313|Ensembl:ENSP00000466557, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16177791; DOI=10.1038/nature03983; RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., RA Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., RA FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., RA Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R., RA Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., RA Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., RA Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., RA O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A., RA Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., RA Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., RA Lander E.S.; RT "DNA sequence and analysis of human chromosome 18."; RL Nature 437:551-555(2005). RN [3] {ECO:0000313|EMBL:EAX01168.1} RP NUCLEOTIDE SEQUENCE. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] {ECO:0000313|Ensembl:ENSP00000466557} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2014) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC010754; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC067796; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC090366; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456351; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471088; EAX01168.1; -; Genomic_DNA. DR RefSeq; NP_001121190.2; NM_001127718.2. DR UniGene; Hs.436367; -. DR jPOST; A0A0A0MTS5; -. DR PeptideAtlas; A0A0A0MTS5; -. DR PRIDE; A0A0A0MTS5; -. DR Ensembl; ENST00000587184; ENSP00000466557; ENSG00000053747. DR GeneID; 3909; -. DR UCSC; uc002kut.5; human. DR CTD; 3909; -. DR EuPathDB; HostDB:ENSG00000053747.15; -. DR HGNC; HGNC:6483; LAMA3. DR OpenTargets; ENSG00000053747; -. DR eggNOG; KOG1836; Eukaryota. DR eggNOG; ENOG410XRDC; LUCA. DR GeneTree; ENSGT00940000155638; -. DR OrthoDB; 2342at2759; -. DR ChiTaRS; LAMA3; human. DR GenomeRNAi; 3909; -. DR Proteomes; UP000005640; Chromosome 18. DR Bgee; ENSG00000053747; Expressed in 173 organ(s), highest expression level in ectocervix. DR ExpressionAtlas; A0A0A0MTS5; baseline and differential. DR GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA. DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro. DR GO; GO:0007155; P:cell adhesion; IEA:InterPro. DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro. DR GO; GO:0030334; P:regulation of cell migration; IEA:InterPro. DR GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR009254; Laminin_aI. DR InterPro; IPR010307; Laminin_dom_II. DR InterPro; IPR002049; Laminin_EGF. DR InterPro; IPR001791; Laminin_G. DR Pfam; PF00053; Laminin_EGF; 2. DR Pfam; PF02210; Laminin_G_2; 5. DR Pfam; PF06008; Laminin_I; 2. DR Pfam; PF06009; Laminin_II; 1. DR SMART; SM00180; EGF_Lam; 2. DR SMART; SM00282; LamG; 5. DR SUPFAM; SSF49899; SSF49899; 5. DR PROSITE; PS01248; EGF_LAM_1; 1. DR PROSITE; PS50027; EGF_LAM_2; 2. DR PROSITE; PS50025; LAM_G_DOMAIN; 5. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00460, KW ECO:0000256|SAAS:SAAS00966286}; KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460}; KW Proteomics identification {ECO:0000213|EPD:A0A0A0MTS5, KW ECO:0000213|MaxQB:A0A0A0MTS5, ECO:0000213|PeptideAtlas:A0A0A0MTS5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 1668 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014015977. FT DOMAIN 78 124 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 125 177 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 725 926 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 933 1095 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 1102 1262 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 1321 1485 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 1492 1665 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT COILED 244 327 {ECO:0000256|SAM:Coils}. FT COILED 356 397 {ECO:0000256|SAM:Coils}. FT COILED 433 467 {ECO:0000256|SAM:Coils}. FT COILED 470 504 {ECO:0000256|SAM:Coils}. FT COILED 660 680 {ECO:0000256|SAM:Coils}. FT COILED 698 718 {ECO:0000256|SAM:Coils}. FT DISULFID 97 106 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 125 137 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 148 157 {ECO:0000256|PROSITE-ProRule:PRU00460}. SQ SEQUENCE 1668 AA; 184024 MW; 6EBF5FC0A541BF31 CRC64; MPPAVRRSAC SMGWLWIFGA ALGQCLGYSS QQQRVPFLQP PGQSQLQASY VEFRPSQGCS PGYYRDHKGL YTGRCVPCNC NGHSNQCQDG SGICVNCQHN TAGEHCERCQ EGYYGNAVHG SCRACPCPHT NSFATGCVVN GGDVRCSCKA GYTGTQCERC APGYFGNPQK FGGSCQPCSC NSNGQLGSCH PLTGDCINQE PKDSSPAEEC DDCDSCVMTL LNDLATMGEQ LRLVKSQLQG LSASAGLLEQ MRHMETQAKD LRNQLLNYRS AISNHGSKIE GLERELTDLN QEFETLQEKA QVNSRKAQTL NNNVNRATQS AKELDVKIKN VIRNVHMLNR IRTWQKTHQG ENNGLANSIR DSLNEYEAKL SDLRARLQEA AAQAKQANGL NQENERALGA IQRQVKEINS LQSDFTKYLT TADSSLLQTN IALQLMEKSQ KEYEKLAASL NEARQELSDK VRELSRSAGK TSLVEEAEKH ARSLQELAKQ LEEIKRNASG DELVRCAVDA ATAYENILNA IKAAEDAANR AASASESALQ TVIKEDLPRK AKTLSSNSDK LLNEAKMTQK KLKQEVSPAL NNLQQTLNIV TVQKEVIDTN LTTLRDGLHG IQRGDIDAMI SSAKSMVRKA NDITDEVLDG LNPIQTDVER IKDTYGRTQN EDFKKALTDA DNSVNKLTNK LPDLWRKIES INQQLLPLGN ISDNMDRIRE LIQQARDAAS KVAVPMRFNG KSGVEVRLPN DLEDLKGYTS LSLFLQRPNS RENGGTENMF VMYLGNKDAS RDYIGMAVVD GQLTCVYNLG DREAELQVDQ ILTKSETKEA VMDRVKFQRI YQFARLNYTK GATSSKPETP GVYDMDGRNS NTLLNLDPEN VVFYVGGYPP DFKLPSRLSF PPYKGCIELD DLNENVLSLY NFKKTFNLNT TEVEPCRRRK EESDKNYFEG TGYARVPTQP HAPIPTFGQT IQTTVDRGLL FFAENGDRFI SLNIEDGKLM VRYKLNSELP KERGVGDAIN NGRDHSIQIK IGKLQKRMWI NVDVQNTIID GEVFDFSTYY LGGIPIAIRE RFNISTPAFR GCMKNLKKTS GVVRLNDTVG VTKKCSEDWK LVRSASFSRG GQLSFTDLGL PPTDHLQASF GFQTFQPSGI LLDHQTWTRN LQVTLEDGYI ELSTSDSGGP IFKSPQTYMD GLLHYVSVIS DNSGLRLLID DQLLRNSKRL KHISSSRQSL RLGGSNFEGC ISNVFVQRLS LSPEVLDLTS NSLKRDVSLG GCSLNKPPFL MLLKGSTRFN KTKTFRINQL LQDTPVASPR SVKVWQDACS PLPKTQANHG ALQFGDIPTS HLLFKLPQEL LKPRSQFAVD MQTTSSRGLV FHTGTKNSFM ALYLSKGRLV FALGTDGKKL RIKSKEKCND GKWHTVVFGH DGEKGRLVVD GLRAREGSLP GNSTISIRAP VYLGSPPSGK PKSLPTNSFV GCLKNFQLDS KPLYTPSSSF GVSSCLGGPL EKGIYFSEEG GHVVLAHSVL LGPEFKLVFS IRPRSLTGIL IHIGSQPGKH LCVYLEAGKV TASMDSGAGG TSTSVTPKQS LCDGQWHSVA VTIKQHILHL ELDTDSSYTA GQIPFPPAST QEPLHLGGAP ANLTTLRIPV WKSFFGCLRN IHVNHIPVPV TEALEVQGPV SLNGCPDQ //