ID   A0A0A0MTJ0_HUMAN        Unreviewed;       764 AA.
AC   A0A0A0MTJ0;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   16-JAN-2019, entry version 40.
DE   RecName: Full=Thyrotropin receptor {ECO:0000256|RuleBase:RU361222};
GN   Name=TSHR {ECO:0000256|RuleBase:RU361222,
GN   ECO:0000313|Ensembl:ENSP00000441235};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000441235, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000441235, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000441235}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
CC   -!- FUNCTION: Receptor for the thyroid-stimulating hormone (TSH) or
CC       thyrotropin. Also acts as a receptor for the heterodimeric
CC       glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity
CC       of this receptor is mediated by G proteins which activate
CC       adenylate cyclase. Plays a central role in controlling thyroid
CC       cell metabolism. {ECO:0000256|RuleBase:RU361222}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361222}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361222}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       FSH/LSH/TSH subfamily. {ECO:0000256|RuleBase:RU361222}.
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DR   EMBL; AC007262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL136040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_000360.2; NM_000369.2.
DR   RefSeq; XP_005268094.1; XM_005268037.4.
DR   UniGene; Hs.160411; -.
DR   PRIDE; A0A0A0MTJ0; -.
DR   Ensembl; ENST00000298171; ENSP00000298171; ENSG00000165409.
DR   Ensembl; ENST00000541158; ENSP00000441235; ENSG00000165409.
DR   GeneID; 7253; -.
DR   KEGG; hsa:7253; -.
DR   UCSC; uc001xvd.1; human.
DR   CTD; 7253; -.
DR   EuPathDB; HostDB:ENSG00000165409.15; -.
DR   HGNC; HGNC:12373; TSHR.
DR   OpenTargets; ENSG00000165409; -.
DR   eggNOG; KOG2087; Eukaryota.
DR   eggNOG; ENOG410XR1T; LUCA.
DR   GeneTree; ENSGT00940000156510; -.
DR   KO; K04249; -.
DR   OMA; DYTVCGG; -.
DR   OrthoDB; 257031at2759; -.
DR   ChiTaRS; TSHR; human.
DR   GenomeRNAi; 7253; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000165409; Expressed in 90 organ(s), highest expression level in left lobe of thyroid gland.
DR   ExpressionAtlas; A0A0A0MTJ0; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004996; F:thyroid-stimulating hormone receptor activity; IEA:Ensembl.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
DR   GO; GO:0030183; P:B cell differentiation; IEA:Ensembl.
DR   GO; GO:0090103; P:cochlea morphogenesis; IEA:Ensembl.
DR   GO; GO:0071542; P:dopaminergic neuron differentiation; IEA:Ensembl.
DR   GO; GO:0060122; P:inner ear receptor cell stereocilium organization; IEA:Ensembl.
DR   GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IEA:Ensembl.
DR   GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
DR   GO; GO:0040012; P:regulation of locomotion; IEA:Ensembl.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR002131; Gphrmn_rcpt_fam.
DR   InterPro; IPR026906; LRR_5.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002274; TSH_rcpt.
DR   InterPro; IPR034298; TSHR/LHCGR/FSHR.
DR   PANTHER; PTHR24372; PTHR24372; 1.
DR   PANTHER; PTHR24372:SF0; PTHR24372:SF0; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   Pfam; PF13306; LRR_5; 2.
DR   PRINTS; PR00373; GLYCHORMONER.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01145; TSHRECEPTOR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane {ECO:0000256|RuleBase:RU361222};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU361222};
KW   Leucine-rich repeat {ECO:0000256|SAAS:SAAS00619388};
KW   Membrane {ECO:0000256|RuleBase:RU361222};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0A0MTJ0};
KW   Receptor {ECO:0000256|RuleBase:RU361222};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00619387};
KW   Signal {ECO:0000256|RuleBase:RU361222};
KW   Transducer {ECO:0000256|RuleBase:RU361222};
KW   Transmembrane {ECO:0000256|RuleBase:RU361222};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361222}.
FT   SIGNAL        1     21       {ECO:0000256|RuleBase:RU361222}.
FT   CHAIN        22    764       Thyrotropin receptor.
FT                                {ECO:0000256|RuleBase:RU361222}.
FT                                /FTId=PRO_5013980011.
FT   TRANSMEM    419    440       Helical. {ECO:0000256|RuleBase:RU361222}.
FT   TRANSMEM    452    477       Helical. {ECO:0000256|RuleBase:RU361222}.
FT   TRANSMEM    497    517       Helical. {ECO:0000256|RuleBase:RU361222}.
FT   TRANSMEM    538    560       Helical. {ECO:0000256|RuleBase:RU361222}.
FT   TRANSMEM    580    606       Helical. {ECO:0000256|RuleBase:RU361222}.
FT   TRANSMEM    627    649       Helical. {ECO:0000256|RuleBase:RU361222}.
FT   TRANSMEM    661    681       Helical. {ECO:0000256|RuleBase:RU361222}.
FT   DOMAIN      431    678       G_PROTEIN_RECEP_F1_2.
FT                                {ECO:0000259|PROSITE:PS50262}.
SQ   SEQUENCE   764 AA;  86844 MW;  27EE9CEBFD650D45 CRC64;
     MRPADLLQLV LLLDLPRDLG GMGCSSPPCE CHQEEDFRVT CKDIQRIPSL PPSTQTLKLI
     ETHLRTIPSH AFSNLPNISR IYVSIDVTLQ QLESHSFYNL SKVTHIEIRN TRNLTYIDPD
     ALKELPLLKF LGIFNTGLKM FPDLTKVYST DIFFILEITD NPYMTSIPVN AFQGLCNETL
     TLKLYNNGFT SVQGYAFNGT KLDAVYLNKN KYLTVIDKDA FGGVYSGPSL LDVSQTSVTA
     LPSKGLEHLK ELIARNTWTL KKLPLSLSFL HLTRADLSYP SHCCAFKNQK KIRGILESLM
     CNESSMQSLR QRKSVNALNS PLHQEYEENL GDSIVGYKEK SKFQDTHNNA HYYVFFEEQE
     DEIIGFGQEL KNPQEETLQA FDSHYDYTIC GDSEDMVCTP KSDEFNPCED IMGYKFLRIV
     VWFVSLLALL GNVFVLLILL TSHYKLNVPR FLMCNLAFAD FCMGMYLLLI ASVDLYTHSE
     YYNHAIDWQT GPGCNTAGFF TVFASELSVY TLTVITLERW YAITFAMRLD RKIRLRHACA
     IMVGGWVCCF LLALLPLVGI SSYAKVSICL PMDTETPLAL AYIVFVLTLN IVAFVIVCCC
     YVKIYITVRN PQYNPGDKDT KIAKRMAVLI FTDFICMAPI SFYALSAILN KPLITVSNSK
     ILLVLFYPLN SCANPFLYAI FTKAFQRDVF ILLSKFGICK RQAQAYRGQR VPPKNSTDIQ
     VQKVTHEMRQ GLHNMEDVYE LIENSHLTPK KQGQISEEYM QTVL
//