ID   A0A0A0MTH0_HUMAN        Unreviewed;       817 AA.
AC   A0A0A0MTH0;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   16-JAN-2019, entry version 33.
DE   SubName: Full=Neuroligin-4, X-linked {ECO:0000313|Ensembl:ENSP00000439203};
GN   Name=NLGN4X {ECO:0000313|Ensembl:ENSP00000439203};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000439203, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000439203, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA   Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA   Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA   Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA   Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA   Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA   Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA   Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA   Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA   Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA   Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA   Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA   Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA   Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA   Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA   Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA   Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA   Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA   Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA   Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA   Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA   Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA   Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA   Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA   de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA   Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA   Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA   Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA   Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA   Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA   Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA   Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA   Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA   Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA   Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA   Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA   Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA   Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA   Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA   Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA   Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA   Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA   Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA   Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000439203}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
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DR   EMBL; AC078989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC079173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC097259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC112654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A0A0MTH0; -.
DR   ESTHER; human-NLGN4X; Neuroligin.
DR   EPD; A0A0A0MTH0; -.
DR   jPOST; A0A0A0MTH0; -.
DR   Ensembl; ENST00000538097; ENSP00000439203; ENSG00000146938.
DR   UCSC; uc064xwt.1; human.
DR   EuPathDB; HostDB:ENSG00000146938.14; -.
DR   HGNC; HGNC:14287; NLGN4X.
DR   OpenTargets; ENSG00000146938; -.
DR   eggNOG; KOG1516; Eukaryota.
DR   eggNOG; COG2272; LUCA.
DR   OMA; TYHISFG; -.
DR   ChiTaRS; NLGN4X; human.
DR   Proteomes; UP000005640; Chromosome X.
DR   Bgee; ENSG00000146938; Expressed in 173 organ(s), highest expression level in dorsal root ganglion.
DR   ExpressionAtlas; A0A0A0MTH0; baseline and differential.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0045202; C:synapse; IEA:InterPro.
DR   GO; GO:0042043; F:neurexin family protein binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0050808; P:synapse organization; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019819; Carboxylesterase_B_CS.
DR   InterPro; IPR000460; Nlgn.
DR   InterPro; IPR030025; NLGN4.
DR   PANTHER; PTHR43903:SF5; PTHR43903:SF5; 1.
DR   Pfam; PF00135; COesterase; 1.
DR   PRINTS; PR01090; NEUROLIGIN.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0A0MTH0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    817       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001967321.
FT   TRANSMEM    676    699       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       26    591       COesterase. {ECO:0000259|Pfam:PF00135}.
SQ   SEQUENCE   817 AA;  91895 MW;  7C05F8FFDDA7A403 CRC64;
     MLNSNVLLWL TALAIKFTLI DSQAQYPVVN TNYGKIRGLR TPLPNEILGP VEQYLGVPYA
     SPPTGERRFQ PPEPPSSWTG IRNTTQFAAV CPQHLDERSL LHDMLPIWFT ANLDTLMTYV
     QDQNEDCLYL NIYVPTEDGA NTKKNADDIT SNDRGEDEDI HDQNSKKPVM VYIHGGSYME
     GTGNMIDGSI LASYGNVIVI TINYRLGILG FLSTGDQAAK GNYGLLDQIQ ALRWIEENVG
     AFGGDPKRVT IFGSGAGASC VSLLTLSHYS EGLFQKAIIQ SGTALSSWAV NYQPAKYTRI
     LADKVGCNML DTTDMVECLR NKNYKELIQQ TITPATYHIA FGPVIDGDVI PDDPQILMEQ
     GEFLNYDIML GVNQGEGLKF VDGIVDNEDG VTPNDFDFSV SNFVDNLYGY PEGKDTLRET
     IKFMYTDWAD KENPETRRKT LVALFTDHQW VAPAVATADL HAQYGSPTYF YAFYHHCQSE
     MKPSWADSAH GDEVPYVFGI PMIGPTELFS CNFSKNDVML SAVVMTYWTN FAKTGDPNQP
     VPQDTKFIHT KPNRFEEVAW SKYNPKDQLY LHIGLKPRVR DHYRATKVAF WLELVPHLHN
     LNEIFQYVST TTKVPPPDMT SFPYGTRRSP AKIWPTTKRP AITPANNPKH SKDPHKTGPE
     DTTVLIETKR DYSTELSVTI AVGASLLFLN ILAFAALYYK KDKRRHETHR RPSPQRNTTN
     DIAHIQNEEI MSLQMKQLEH DHECESLQAH DTLRLTCPPD YTLTLRRSPD DIPLMTPNTI
     TMIPNTLTGM QPLHTFNTFS GGQNSTNLPH GHSTTRV
//