ID   A0A0A0MTG5_HUMAN        Unreviewed;       159 AA.
AC   A0A0A0MTG5;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   16-JAN-2019, entry version 29.
DE   RecName: Full=Interleukin-7 {ECO:0000256|PIRNR:PIRNR001942};
DE            Short=IL-7 {ECO:0000256|PIRNR:PIRNR001942};
GN   Name=IL7 {ECO:0000313|Ensembl:ENSP00000438922};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000438922, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000438922, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000438922}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
CC   -!- FUNCTION: Hematopoietic growth factor capable of stimulating the
CC       proliferation of lymphoid progenitors. It is important for
CC       proliferation during certain stages of B-cell maturation.
CC       {ECO:0000256|PIRNR:PIRNR001942}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR001942}.
CC   -!- SIMILARITY: Belongs to the IL-7/IL-9 family.
CC       {ECO:0000256|PIRNR:PIRNR001942}.
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DR   EMBL; AC083837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC100854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001186816.1; NM_001199887.1.
DR   UniGene; Hs.591873; -.
DR   PeptideAtlas; A0A0A0MTG5; -.
DR   PRIDE; A0A0A0MTG5; -.
DR   Ensembl; ENST00000541183; ENSP00000438922; ENSG00000104432.
DR   GeneID; 3574; -.
DR   UCSC; uc022awh.2; human.
DR   CTD; 3574; -.
DR   EuPathDB; HostDB:ENSG00000104432.12; -.
DR   HGNC; HGNC:6023; IL7.
DR   OpenTargets; ENSG00000104432; -.
DR   GeneTree; ENSGT00390000004451; -.
DR   OrthoDB; 1433958at2759; -.
DR   ChiTaRS; IL7; human.
DR   GenomeRNAi; 3574; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000104432; Expressed in 160 organ(s), highest expression level in sperm.
DR   ExpressionAtlas; A0A0A0MTG5; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005139; F:interleukin-7 receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.50; -; 1.
DR   InterPro; IPR001181; IL-7.
DR   InterPro; IPR018049; IL-7/IL-9_CS.
DR   InterPro; IPR000226; IL-7/IL-9_fam.
DR   InterPro; IPR038325; IL7_sf.
DR   PANTHER; PTHR45542; PTHR45542; 1.
DR   Pfam; PF01415; IL7; 1.
DR   PIRSF; PIRSF001942; IL-7; 1.
DR   PRINTS; PR00435; INTERLEUKIN7.
DR   SMART; SM00127; IL7; 1.
DR   PROSITE; PS00255; INTERLEUKIN_7_9; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Cytokine {ECO:0000256|PIRNR:PIRNR001942};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR001942-1};
KW   Growth factor {ECO:0000256|PIRNR:PIRNR001942};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0A0MTG5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|PIRNR:PIRNR001942};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    159       Interleukin-7. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001967146.
FT   DISULFID     27    148       {ECO:0000256|PIRSR:PIRSR001942-1}.
FT   DISULFID     59    136       {ECO:0000256|PIRSR:PIRSR001942-1}.
FT   DISULFID     72    117       {ECO:0000256|PIRSR:PIRSR001942-1}.
SQ   SEQUENCE   159 AA;  18353 MW;  2358958E62FB5B95 CRC64;
     MFHVSFRYIF GLPPLILVLL PVASSDCDIE GKDGKQYESV LMVSIDQLLD SMKEIGSNCL
     NNEFNFFKRH ICDANKEGMF LFRAARKLRQ FLKMNSTGDF DLHLLKVSEG TTILLNCTGQ
     EENKSLKEQK KLNDLCFLKR LLQEIKTCWN KILMGTKEH
//