ID   A0A0A0MTC7_HUMAN        Unreviewed;      1816 AA.
AC   A0A0A0MTC7;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   16-JAN-2019, entry version 44.
DE   SubName: Full=Laminin subunit alpha-4 {ECO:0000313|Ensembl:ENSP00000429488};
GN   Name=LAMA4 {ECO:0000313|Ensembl:ENSP00000429488};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000429488, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000429488, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000429488}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   EMBL; AL590106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; Z99289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001098677.2; NM_001105207.2.
DR   RefSeq; NP_002281.3; NM_002290.4.
DR   RefSeq; XP_016866343.1; XM_017010854.1.
DR   UniGene; Hs.654572; -.
DR   jPOST; A0A0A0MTC7; -.
DR   PRIDE; A0A0A0MTC7; -.
DR   Ensembl; ENST00000389463; ENSP00000374114; ENSG00000112769.
DR   Ensembl; ENST00000424408; ENSP00000416470; ENSG00000112769.
DR   Ensembl; ENST00000522006; ENSP00000429488; ENSG00000112769.
DR   GeneID; 3910; -.
DR   UCSC; uc003pvt.4; human.
DR   CTD; 3910; -.
DR   EuPathDB; HostDB:ENSG00000112769.18; -.
DR   HGNC; HGNC:6484; LAMA4.
DR   OpenTargets; ENSG00000112769; -.
DR   eggNOG; ENOG410IP6G; Eukaryota.
DR   eggNOG; ENOG410Z3D5; LUCA.
DR   GeneTree; ENSGT00940000159970; -.
DR   OrthoDB; 2342at2759; -.
DR   ChiTaRS; LAMA4; human.
DR   GenomeRNAi; 3910; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000112769; Expressed in 221 organ(s), highest expression level in lung.
DR   ExpressionAtlas; A0A0A0MTC7; baseline and differential.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR   GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR   GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR009254; Laminin_aI.
DR   InterPro; IPR010307; Laminin_dom_II.
DR   InterPro; IPR002049; Laminin_EGF.
DR   InterPro; IPR001791; Laminin_G.
DR   Pfam; PF00053; Laminin_EGF; 3.
DR   Pfam; PF02210; Laminin_G_2; 5.
DR   Pfam; PF06008; Laminin_I; 1.
DR   Pfam; PF06009; Laminin_II; 1.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00180; EGF_Lam; 3.
DR   SMART; SM00282; LamG; 5.
DR   SUPFAM; SSF49899; SSF49899; 5.
DR   PROSITE; PS01248; EGF_LAM_1; 1.
DR   PROSITE; PS50027; EGF_LAM_2; 3.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 5.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00814887};
KW   Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00580772};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A0A0MTC7,
KW   ECO:0000213|PeptideAtlas:A0A0A0MTC7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00966518};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28   1816       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014506434.
FT   DOMAIN       82    131       Laminin EGF-like.
FT                                {ECO:0000259|PROSITE:PS50027}.
FT   DOMAIN      132    186       Laminin EGF-like.
FT                                {ECO:0000259|PROSITE:PS50027}.
FT   DOMAIN      187    240       Laminin EGF-like.
FT                                {ECO:0000259|PROSITE:PS50027}.
FT   DOMAIN      826   1028       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN     1040   1220       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN     1227   1395       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN     1462   1633       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN     1640   1813       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   COILED      332    359       {ECO:0000256|SAM:Coils}.
FT   COILED      374    394       {ECO:0000256|SAM:Coils}.
FT   COILED      471    498       {ECO:0000256|SAM:Coils}.
FT   COILED      580    607       {ECO:0000256|SAM:Coils}.
FT   COILED      659    682       {ECO:0000256|SAM:Coils}.
FT   COILED      778    798       {ECO:0000256|SAM:Coils}.
FT   DISULFID    101    110       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    157    166       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    212    221       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    224    238       {ECO:0000256|PROSITE-ProRule:PRU00460}.
SQ   SEQUENCE   1816 AA;  201820 MW;  28D7E515B5B2153F CRC64;
     MALSSAWRSV LPLWLLWSAA CSRAASGDDN AFPFDIEGSS AVGRQDPPET SEPRVALGRL
     PPAAEKCNAG FFHTLSGECV PCDCNGNSNE CLDGSGYCVH CQRNTTGEHC EKCLDGYIGD
     SIRGAPQFCQ PCPCPLPHLA NFAESCYRKN GAVRCICNEN YAGPNCERCA PGYYGNPLLI
     GSTCKKCDCS GNSDPNLIFE DCDEVTGQCR NCLRNTTGFK CERCAPGYYG DARIAKNCAV
     CNCGGGPCDS VTGECLEEGF EPPTGCDKCV WDLTDDLRLA ALSIEEGKSG VLSVSSGAAA
     HRHVNEINAT IYLLKTKLSE RENQYALRKI QINNAENTMK SLLSDVEELV EKENQASRKG
     QLVQKESMDT INHASQLVEQ AHDMRDKIQE INNKMLYYGE EHELSPKEIS EKLVLAQKML
     EEIRSRQPFF TQRELVDEEA DEAYELLSQA ESWQRLHNET RTLFPVVLEQ LDDYNAKLSD
     LQEALDQALN YVRDAEDMNR ATAARQRDHE KQQERVREQM EVVNMSLSTS ADSLTTPRLT
     LSELDDIIKN ASGIYAEIDG AKSELQVKLS NLSNLSHDLV QEAIDHAQDL QQEANELSRK
     LHSSDMNGLV QKALDASNVY ENIVNYVSEA NETAEFALNT TDRIYDAVSG IDTQIIYHKD
     ESENLLNQAR ELQAKAESSS DEAVADTSRR VGGALARKSA LKTRLSDAVK QLQAAERGDA
     QQRLGQSRLI TEEANRTTME VQQATAPMAN NLTNWSQNLQ HFDSSAYNTA VNSARDAVRN
     LTEVVPQLLD QLRTVEQKRP ASNVSASIQR IRELIAQTRS VASKIQVSMM FDGQSAVEVH
     SRTSMDDLKA FTSLSLYMKP PVKRPELTET ADQFILYLGS KNAKKEYMGL AIKNDNLVYV
     YNLGTKDVEI PLDSKPVSSW PAYFSIVKIE RVGKHGKVFL TVPSLSSTAE EKFIKKGEFS
     GDDSLLDLDP EDTVFYVGGV PSNFKLPTSL NLPGFVGCLE LATLNNDVIS LYNFKHIYNM
     DPSTSVPCAR DKLAFTQSRA ASYFFDGSGY AVVRDITRRG KFGQVTRFDI EVRTPADNGL
     ILLMVNGSMF FRLEMRNGYL HVFYDFGFSG GPVHLEDTLK KAQINDAKYH EISIIYHNDK
     KMILVVDRRH VKSMDNEKMK IPFTDIYIGG APPEILQSRA LRAHLPLDIN FRGCMKGFQF
     QKKDFNLLEQ TETLGVGYGC PEDSLISRRA YFNGQSFIAS IQKISFFDGF EGGFNFRTLQ
     PNGLLFYYAS GSDVFSISLD NGTVIMDVKG IKVQSVDKQY NDGLSHFVIS SVSPTRYELI
     VDKSRVGSKN PTKGKIEQTQ ASEKKFYFGG SPISAQYANF TGCISNAYFT RVDRDVEVED
     FQRYTEKVHT SLYECPIESS PLFLLHKKGK NLSKPKASQN KKGGKSKDAP SWDPVALKLP
     ERNTPRNSHC HLSNSPRAIE HAYQYGGTAN SRQEFEHLKG DFGAKSQFSI RLRTRSSHGM
     IFYVSDQEEN DFMTLFLAHG RLVYMFNVGH KKLKIRSQEK YNDGLWHDVI FIRERSSGRL
     VIDGLRVLEE SLPPTEATWK IKGPIYLGGV APGKAVKNVQ INSIYSFSGC LSNLQLNGAS
     ITSASQTFSV TPCFEGPMET GTYFSTEGGY VVLDESFNIG LKFEIAFEVR PRSSSGTLVH
     GHSVNGEYLN VHMKNGQVIV KVNNGIRDFS TSVTPKQSLC DGRWHRITVI RDSNVVQLDV
     DSEVNHVVGP LNPKPIDHRE PVFVGGVPES LLTPRLAPSK PFTGCIRHFV IDGHPVSFSK
     AALVSGAVSI NSCPAA
//