ID   A0A0A0MT68_HUMAN        Unreviewed;       288 AA.
AC   A0A0A0MT68;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   05-DEC-2018, entry version 33.
DE   RecName: Full=Deoxyribonuclease {ECO:0000256|PIRNR:PIRNR000988};
GN   Name=DNASE1L3 {ECO:0000313|Ensembl:ENSP00000417047};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000417047, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000417047, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000417047}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DNase I family.
CC       {ECO:0000256|PIRNR:PIRNR000988}.
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DR   EMBL; AC137936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A0A0MT68; -.
DR   EPD; A0A0A0MT68; -.
DR   PeptideAtlas; A0A0A0MT68; -.
DR   Ensembl; ENST00000483681; ENSP00000417047; ENSG00000163687.
DR   UCSC; uc062kyy.1; human.
DR   EuPathDB; HostDB:ENSG00000163687.13; -.
DR   HGNC; HGNC:2959; DNASE1L3.
DR   OpenTargets; ENSG00000163687; -.
DR   eggNOG; ENOG410IHHA; Eukaryota.
DR   eggNOG; ENOG410ZR9A; LUCA.
DR   GeneTree; ENSGT00940000153950; -.
DR   ChiTaRS; DNASE1L3; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000163687; Expressed in 164 organ(s), highest expression level in visceral pleura.
DR   ExpressionAtlas; A0A0A0MT68; baseline and differential.
DR   GO; GO:0004536; F:deoxyribonuclease activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:InterPro.
DR   Gene3D; 3.60.10.10; -; 1.
DR   InterPro; IPR018057; Deoxyribonuclease-1_AS.
DR   InterPro; IPR016202; DNase_I.
DR   InterPro; IPR033125; DNASE_I_2.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   PIRSF; PIRSF000988; DNase_I_euk; 1.
DR   PRINTS; PR00130; DNASEI.
DR   SMART; SM00476; DNaseIc; 1.
DR   SUPFAM; SSF56219; SSF56219; 1.
DR   PROSITE; PS00919; DNASE_I_1; 1.
DR   PROSITE; PS00918; DNASE_I_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR000988-2};
KW   Endonuclease {ECO:0000256|PIRNR:PIRNR000988};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR000988};
KW   Nuclease {ECO:0000256|PIRNR:PIRNR000988};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A0A0MT68,
KW   ECO:0000213|PeptideAtlas:A0A0A0MT68};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    288       Deoxyribonuclease.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001974223.
FT   DOMAIN       25    240       Endo/exonuclease/phosphatase.
FT                                {ECO:0000259|Pfam:PF03372}.
FT   ACT_SITE    100    100       {ECO:0000256|PIRSR:PIRSR000988-1}.
FT   ACT_SITE    155    155       {ECO:0000256|PIRSR:PIRSR000988-1}.
FT   DISULFID    194    231       Essential for enzymatic activity.
FT                                {ECO:0000256|PIRSR:PIRSR000988-2}.
SQ   SEQUENCE   288 AA;  33555 MW;  7EF0A350E2E829F8 CRC64;
     MSRELAPLLL LLLSIHSALA MRICSFNVRS FGESKQEDKN AMDVIVKVIK RCDIILVMEI
     KDSNNRICPI LMEKLNRNSR RGITYNYVIS SRLGRNTYKE QYAFLYKEKL VSVKRSYHYH
     DYQDGDADVF SREPFVVWFQ SPHTAVKDFV IIPLHTTPET SVKEIDELVE VYTDVKHRWK
     AENFIFMGDF NAGCSYVPKK AWKNIRLRTD PRFVWLIGDQ EDTTVKKSTN CAYDRIVLRG
     QEIVSSVVPK SNSVFDFQKA YKLTEEEVRL PSCLSMPLSW KDELAWAT
//