ID   A0A0A0MSZ8_HUMAN        Unreviewed;       447 AA.
AC   A0A0A0MSZ8;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   16-JAN-2019, entry version 32.
DE   SubName: Full=Leukocyte immunoglobulin-like receptor subfamily B member 4 {ECO:0000313|Ensembl:ENSP00000408995};
GN   Name=LILRB4 {ECO:0000313|Ensembl:ENSP00000408995};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000408995, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000408995, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [3] {ECO:0000313|Ensembl:ENSP00000408995}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
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DR   EMBL; AC243962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC245036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001265356.2; NM_001278427.3.
DR   UniGene; Hs.67846; -.
DR   UniGene; Hs.731841; -.
DR   jPOST; A0A0A0MSZ8; -.
DR   PeptideAtlas; A0A0A0MSZ8; -.
DR   PRIDE; A0A0A0MSZ8; -.
DR   Ensembl; ENST00000430952; ENSP00000408995; ENSG00000186818.
DR   GeneID; 11006; -.
DR   UCSC; uc002qgq.5; human.
DR   CTD; 11006; -.
DR   EuPathDB; HostDB:ENSG00000186818.12; -.
DR   HGNC; HGNC:6608; LILRB4.
DR   OpenTargets; ENSG00000186818; -.
DR   eggNOG; ENOG410IHKK; Eukaryota.
DR   eggNOG; ENOG411142H; LUCA.
DR   GeneTree; ENSGT00940000153160; -.
DR   OrthoDB; 1000446at2759; -.
DR   ChiTaRS; LILRB4; human.
DR   GenomeRNAi; 11006; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000186818; Expressed in 151 organ(s), highest expression level in layer of synovial tissue.
DR   ExpressionAtlas; A0A0A0MSZ8; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013151; Immunoglobulin.
DR   Pfam; PF00047; ig; 1.
DR   Pfam; PF13895; Ig_2; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A0A0MSZ8,
KW   ECO:0000213|PeptideAtlas:A0A0A0MSZ8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    447       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001974217.
FT   TRANSMEM    260    280       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       27    118       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      124    218       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   447 AA;  49198 MW;  60368274B7C6F63D CRC64;
     MIPTFTALLC LGLSLGPRTH MQAGPLPKPT LWAEPGSVIS WGNSVTIWCQ GTLEAREYRL
     DKEESPAPWD RQNPLEPKNK ARFSIPSMTE DYAGRYRCYY RSPVGWSQPS DPLELVMTGA
     YSKPTLSALP SPLVTSGKSV TLLCQSRSPM DTFLLIKERA AHPLLHLRSE HGAQQHQAEF
     PMSPVTSVHG GTYRCFSSHG FSHYLLSHPS DPLELIVSGS LEGPRPSPTR SVSTAAGPED
     QPLMPTGSVP HSGLRRHWEV LIGVLVVSIL LLSLLLFLLL QHWRQGKHRT LAQRQADFQR
     PPGAAEPEPK DGGLQRRSSP AADVQGENFC AAVKNTQPED GVEMDTRSPH DEDPQAVTYA
     KVKHSRPRRE MASPPSPLSG EFLDTKDRQA EEDRQMDTEA AASEAPQDVT YARLHSFTLR
     QKATEPPPSQ EGASPAEPSV YATLAIH
//