ID A0A0A0MSV6_HUMAN Unreviewed; 228 AA. AC A0A0A0MSV6; DT 07-JAN-2015, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 6. DT 16-JAN-2019, entry version 32. DE SubName: Full=Complement C1q subcomponent subunit B {ECO:0000313|Ensembl:ENSP00000404606}; DE Flags: Fragment; GN Name=C1QB {ECO:0000313|Ensembl:ENSP00000404606}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000404606, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000404606, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., RA Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., RA Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., RA James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., RA Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., RA Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., RA Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., RA Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., RA Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., RA Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., RA Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., RA Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., RA Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., RA Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., RA Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., RA Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., RA Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., RA Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., RA Porter K.M., Prigmore E.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000404606} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2014) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00588336}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL158086; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A0A0MSV6; -. DR SMR; A0A0A0MSV6; -. DR jPOST; A0A0A0MSV6; -. DR PeptideAtlas; A0A0A0MSV6; -. DR Ensembl; ENST00000432749; ENSP00000404606; ENSG00000173369. DR UCSC; uc057deb.1; human. DR EuPathDB; HostDB:ENSG00000173369.15; -. DR HGNC; HGNC:1242; C1QB. DR OpenTargets; ENSG00000173369; -. DR eggNOG; ENOG410IWVM; Eukaryota. DR eggNOG; ENOG4111MQB; LUCA. DR GeneTree; ENSGT00940000161091; -. DR ChiTaRS; C1QB; human. DR Proteomes; UP000005640; Chromosome 1. DR Bgee; ENSG00000173369; Expressed in 208 organ(s), highest expression level in spleen. DR ExpressionAtlas; A0A0A0MSV6; baseline and differential. DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0006958; P:complement activation, classical pathway; IEA:InterPro. DR Gene3D; 2.60.120.40; -; 1. DR InterPro; IPR001073; C1q_dom. DR InterPro; IPR008160; Collagen. DR InterPro; IPR037573; Complement_C1qB. DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom. DR PANTHER; PTHR44403:SF2; PTHR44403:SF2; 1. DR Pfam; PF00386; C1q; 1. DR Pfam; PF01391; Collagen; 1. DR PRINTS; PR00007; COMPLEMNTC1Q. DR SMART; SM00110; C1Q; 1. DR SUPFAM; SSF49842; SSF49842; 1. DR PROSITE; PS50871; C1Q; 1. PE 1: Evidence at protein level; KW Collagen {ECO:0000256|SAAS:SAAS00562261}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:A0A0A0MSV6, KW ECO:0000213|PeptideAtlas:A0A0A0MSV6}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Secreted {ECO:0000256|SAAS:SAAS00588327}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 228 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008202300. FT DOMAIN 115 228 C1q. {ECO:0000259|PROSITE:PS50871}. FT NON_TER 228 228 {ECO:0000313|Ensembl:ENSP00000404606}. SQ SEQUENCE 228 AA; 24031 MW; 638FF7CBB56BD9B1 CRC64; MKIPWGSIPV LMLLLLLGLI DISQAQLSCT GPPAIPGIPG IPGTPGPDGQ PGTPGIKGEK GLPGLAGDHG EFGEKGDPGI PGNPGKVGPK GPMGPKGGPG APGAPGPKGE SGDYKATQKI AFSATRTINV PLRRDQTIRF DHVITNMNNN YEPRSGKFTC KVPGLYYFTY HASSRGNLCV NLMRGRERAQ KVVTFCDYAY NTFQVTTGGM VLKLEQGENV FLQATDKN //