ID   A0A0A0MSS2_HUMAN        Unreviewed;      2344 AA.
AC   A0A0A0MSS2;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   16-JAN-2019, entry version 35.
DE   SubName: Full=Otogelin-like protein {ECO:0000313|Ensembl:ENSP00000400895};
GN   Name=OTOGL {ECO:0000313|Ensembl:ENSP00000400895};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000400895, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000400895, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RG   Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA   Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D.,
RA   Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA   Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA   Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA   Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V.,
RA   Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J.,
RA   Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA   Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA   Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA   Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA   Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA   Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA   Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA   Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA   Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA   Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA   Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA   Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA   Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA   Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA   Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA   Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA   Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA   Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA   Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA   Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA   Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA   Kucherlapati R., Weinstock G., Gibbs R.A., null.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000400895}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00567783}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC078817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC083812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC092945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_775862.3; NM_173591.3.
DR   UniGene; Hs.723594; -.
DR   ProteinModelPortal; A0A0A0MSS2; -.
DR   jPOST; A0A0A0MSS2; -.
DR   PRIDE; A0A0A0MSS2; -.
DR   Ensembl; ENST00000458043; ENSP00000400895; ENSG00000165899.
DR   GeneID; 283310; -.
DR   KEGG; hsa:283310; -.
DR   UCSC; uc001szd.3; human.
DR   CTD; 283310; -.
DR   EuPathDB; HostDB:ENSG00000165899.10; -.
DR   HGNC; HGNC:26901; OTOGL.
DR   OpenTargets; ENSG00000165899; -.
DR   eggNOG; KOG1216; Eukaryota.
DR   eggNOG; ENOG410XNSK; LUCA.
DR   GeneTree; ENSGT00940000160698; -.
DR   OMA; DCSHCIE; -.
DR   OrthoDB; 12226at2759; -.
DR   PhylomeDB; A0A0A0MSS2; -.
DR   ChiTaRS; OTOGL; human.
DR   GenomeRNAi; 283310; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   Bgee; ENSG00000165899; Expressed in 87 organ(s), highest expression level in right atrium auricular region.
DR   ExpressionAtlas; A0A0A0MSS2; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046556; F:alpha-L-arabinofuranosidase activity; IEA:InterPro.
DR   GO; GO:0046373; P:L-arabinose metabolic process; IEA:InterPro.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR   InterPro; IPR007934; AbfB_ABD.
DR   InterPro; IPR036195; AbfB_ABD_sf.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR030110; Otogl.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   InterPro; IPR014853; Unchr_dom_Cys-rich.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   PANTHER; PTHR11339:SF225; PTHR11339:SF225; 2.
DR   Pfam; PF05270; AbfB; 1.
DR   Pfam; PF08742; C8; 4.
DR   Pfam; PF01826; TIL; 1.
DR   Pfam; PF00094; VWD; 4.
DR   SMART; SM00832; C8; 4.
DR   SMART; SM00041; CT; 1.
DR   SMART; SM00215; VWC_out; 2.
DR   SMART; SM00216; VWD; 4.
DR   SUPFAM; SSF110221; SSF110221; 1.
DR   SUPFAM; SSF57567; SSF57567; 4.
DR   PROSITE; PS01225; CTCK_2; 1.
DR   PROSITE; PS51233; VWFD; 4.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00039,
KW   ECO:0000256|SAAS:SAAS00509702};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0A0MSS2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00509699};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23   2344       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001967279.
FT   DOMAIN      113    326       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN      473    683       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN      938   1141       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN     1526   1746       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN     2252   2344       CTCK. {ECO:0000259|PROSITE:PS01225}.
FT   DISULFID   2273   2322       {ECO:0000256|PROSITE-ProRule:PRU00039}.
SQ   SEQUENCE   2344 AA;  263530 MW;  A00FDE98FD6108B5 CRC64;
     MIPWSIFLLH VLLFSLQEYI CASSILMGTS KNGFNENRQK RALLAAQFEA TSPRYFFHDA
     INWGESKIKG SCPYECLNGA FCSKTGTCDC QIFQALGTRC QIIPNMGNGR DGICKTWGQY
     HFETFDGIYY YFPGNCSYIF AKDCGDLEPR YTVWVHNSPK CLGSVYSCYR SISLFFSNQE
     EIRIYGHEIK KNGISLTLPQ TIGQIFIEKL ADYILVKTTF GFSLAWDGIS GIYLKLSEDH
     KGKSCGLCGN YNDIQSDDFI ILQEDYTEDI AMFANSWSVQ TPDDTKCVLT PSDFPNPCSS
     GMPAFEAIFF KCQILLQFPF LSCHEYIDPY LYIASCVNDL CKTDDDETYC RAATEYARAC
     SHAGYPIQDW RDDFPACTDK CDDSFVHRDC ISCCPPTCTF EKQCLGSNLH CLDGCYCPDG
     LVMDNGTCIS LENCPCGFHG LAYSVGSKIE QECTECVCVG GVWNCTEQDC PVQCSVVGDS
     HFTTFDGRHY SFIGMCQYIL VKGTGKDKFT ITLQKAPCEQ NLGLVCLQSI TLILEDDFNK
     QVTLGRGGQI LTSPNQGFNL NGIVEIQTLS SLFILLKTTF GLKILFAIDG ERIYIQLTSA
     WKRRTLGLCG TFNGNIRDDF LSPSGMIEGT PQLHANAWRV SSTCFAPVHV PVVDPCNINQ
     QNIGYAAHCD VIHQELFAPC HIYISPGLYY QLCRHDACKC GSSCLCNALA HYAYLCGQHG
     VPIDFRTQIS FCAVVCQKGM LYHHCSSFCL HSCISLSSPE QCSDDCAEGC NCPEGKFYED
     TLNFCVPIFH CRCHYRGSVY QPGELIPTPS GLCQCSNGTV KCDELATPSA VHICPEGKEY
     FDCRFPDPEL PAGGVNCETT CANLAMNFTC TPSSPCISGC VCAPGMAEHR GKCYVPESCP
     CIWKDWEYLS GEVIATPCYT CVCRRGMFNC TYYPCPAVCT IYGDRHYYSF DGLEYDYISD
     CQVFLIKSAD DSDISVIAQN KKCFDNDIVC SKSVLISVGD TEIYLNDTPY KQKQSGFFLE
     NKSTYQLWKA GYYIVVYFPE KDITILWDRK TTIHIKVGPQ WKNKLSGLCG NFDKCTSNDM
     TTSNNLEVRN ARVFGDSWAL GQCESPDETI KPCEAHQNKF PYAKKECSIL YSDIFASCRN
     VIDVTSFAKN CHEDTCNCNL GGDCECLCTS IAAYAYKCCQ EGISIHWRSS TVCSLDCEYY
     NEGLGEGPYM LASYGQSGLV LGANMTSRSV FCLPRSSVHT SLFFYFMITP GLFKEKVSSL
     ALVSLESAER PNYFLYVHDN DTLSLELWEA NSAFHRRATF FHHQGLWIPG YSAFELYSKK
     GFFIIFTDSS VKASKYDDSE EFKHSSSFSI EEIQAAVPYR KMCEWRYEPC ATPCFKTCSD
     PEALACKFLP PVEGCLPYCP KNMILDEVTL KCVYPRDCIP VIPTEPTLMP PAKPTVPMFT
     VWEMITPSDI TVFDMLTPTT GLECEPQKFD PVYDCSQYIC LNMEWQLYNW SLNCPKDVEM
     PDCGFRGRPV QVNSDICCPE WECPCRCSML SELSIITFDG NNAALYSMAS YILVRIPGEI
     IVAHIEKCSM NQNGNSLKKL APSGRISGLC FKKLNVTTPI HKIIVNRLAR KVEVDSIVVP
     LPFSSQELSI EDSGSMYVIT TPAGLIIKWS HLTGIIDIHF GFRFNLSSYT EGLCGICNED
     PDDDLRMQNG TIITNMEDIG LFIESWEIEK SFEVTMRRPV RNCTEHDCSQ CIDLLNRRIF
     IPCHDKVSPE DFCEKMWINY TYFWNYECDA LSAYVALCNK FDICIQWRTP DYCSLSCPEG
     KEYQPCVRPC EARTCLNQWF YGHTSCLNLR EDCVCKVGTI LHRPHSAQCI PEKECACTDS
     EDQPRTAGEI WNGGIDECTL YKCLENGSII PIEPDCDEEP TPVCEREAEV VMGIIDKWTC
     CSKEVCGCDT TLCETSIPTC TNSQKLIVGH SPLSCCPQYK CECDPLKCPS ISTPECREDQ
     FMIQVRQEEP CCFSPFCVCE SCTKPVPLCH DGEFLTVDLN STHFCCPQYY CVCEPNLCPM
     PLLNCAEDMN LVKENVSGQC CPTWHCECNC ENLIMPTCEV GEFTAIDHNF QSDCGCIQYL
     CEKDDVCVFQ EVSVLNPGQS MIKYLEEDFC YAIECLEEKD NHTGFHTLNF TLVNCSKKCD
     VHQVYTPSPS DYGCCGTCKN VSCKFHMENG TSVVYAVGST WHYNCTTYEC VKTDEGAIIL
     NYTMVCPPFN ETECKMNEGI VKLYNEGCCK ICKREERICQ KVIIKSVIRK QDCMSQSPIN
     VASCDGKCPS ATIYNINIES HLRFCKCCRE NGVRNLSVPL YCSGNGTEIM YTLQEPIDCT
     CQWN
//