ID   A0A0A0MSC4_HUMAN        Unreviewed;        86 AA.
AC   A0A0A0MSC4;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   05-DEC-2018, entry version 23.
DE   SubName: Full=Platelet-derived growth factor subunit A {ECO:0000313|Ensembl:ENSP00000384673};
DE   Flags: Fragment;
GN   Name=PDGFA {ECO:0000313|Ensembl:ENSP00000384673};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000384673, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000384673, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000384673}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
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DR   EMBL; AC147651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A0A0MSC4; -.
DR   PeptideAtlas; A0A0A0MSC4; -.
DR   Ensembl; ENST00000405692; ENSP00000384673; ENSG00000197461.
DR   UCSC; uc064asu.1; human.
DR   EuPathDB; HostDB:ENSG00000197461.13; -.
DR   HGNC; HGNC:8799; PDGFA.
DR   OpenTargets; ENSG00000197461; -.
DR   eggNOG; ENOG410IEXJ; Eukaryota.
DR   eggNOG; ENOG4111GMH; LUCA.
DR   GeneTree; ENSGT00940000159039; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000197461; Expressed in 224 organ(s), highest expression level in left coronary artery.
DR   ExpressionAtlas; A0A0A0MSC4; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006782; PDGF_N.
DR   Pfam; PF04692; PDGF_N; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A0A0MSC4,
KW   ECO:0000213|PeptideAtlas:A0A0A0MSC4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21     86       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001974208.
FT   DOMAIN       21     86       PDGF_N. {ECO:0000259|Pfam:PF04692}.
FT   NON_TER      86     86       {ECO:0000313|Ensembl:ENSP00000384673}.
SQ   SEQUENCE   86 AA;  9755 MW;  C6E2D4AD3344B960 CRC64;
     MRTLACLLLL GCGYLAHVLA EEAEIPREVI ERLARSQIHS IRDLQRLLEI DSVGSEDSLD
     TSLRAHGVHA TKHVPEKRPL PIRRKR
//