ID A0A0A0MSA0_HUMAN Unreviewed; 3277 AA. AC A0A0A0MSA0; DT 07-JAN-2015, integrated into UniProtKB/TrEMBL. DT 07-JAN-2015, sequence version 1. DT 16-JAN-2019, entry version 38. DE SubName: Full=Laminin subunit alpha-3 {ECO:0000313|Ensembl:ENSP00000382432}; GN Name=LAMA3 {ECO:0000313|Ensembl:ENSP00000382432}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000382432, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000382432, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16177791; DOI=10.1038/nature03983; RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., RA Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., RA FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., RA Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R., RA Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., RA Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., RA Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., RA O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A., RA Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., RA Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., RA Lander E.S.; RT "DNA sequence and analysis of human chromosome 18."; RL Nature 437:551-555(2005). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000382432} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2014) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC010754; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC067796; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC090366; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456351; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001121189.2; NM_001127717.2. DR UniGene; Hs.436367; -. DR ProteinModelPortal; A0A0A0MSA0; -. DR jPOST; A0A0A0MSA0; -. DR PeptideAtlas; A0A0A0MSA0; -. DR PRIDE; A0A0A0MSA0; -. DR Ensembl; ENST00000399516; ENSP00000382432; ENSG00000053747. DR GeneID; 3909; -. DR UCSC; uc002kur.4; human. DR CTD; 3909; -. DR EuPathDB; HostDB:ENSG00000053747.15; -. DR HGNC; HGNC:6483; LAMA3. DR OpenTargets; ENSG00000053747; -. DR eggNOG; KOG1836; Eukaryota. DR eggNOG; ENOG410XRDC; LUCA. DR GeneTree; ENSGT00940000155638; -. DR OrthoDB; 2342at2759; -. DR ChiTaRS; LAMA3; human. DR GenomeRNAi; 3909; -. DR Proteomes; UP000005640; Chromosome 18. DR Bgee; ENSG00000053747; Expressed in 173 organ(s), highest expression level in ectocervix. DR ExpressionAtlas; A0A0A0MSA0; baseline and differential. DR GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA. DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro. DR GO; GO:0007155; P:cell adhesion; IEA:InterPro. DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro. DR GO; GO:0030334; P:regulation of cell migration; IEA:InterPro. DR GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro. DR Gene3D; 2.60.120.1490; -; 1. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR009254; Laminin_aI. DR InterPro; IPR010307; Laminin_dom_II. DR InterPro; IPR002049; Laminin_EGF. DR InterPro; IPR001791; Laminin_G. DR InterPro; IPR000034; Laminin_IV. DR InterPro; IPR008211; Laminin_N. DR InterPro; IPR038684; Laminin_N_sf. DR Pfam; PF00052; Laminin_B; 1. DR Pfam; PF00053; Laminin_EGF; 12. DR Pfam; PF02210; Laminin_G_2; 5. DR Pfam; PF06008; Laminin_I; 2. DR Pfam; PF06009; Laminin_II; 1. DR Pfam; PF00055; Laminin_N; 1. DR SMART; SM00181; EGF; 8. DR SMART; SM00180; EGF_Lam; 14. DR SMART; SM00281; LamB; 1. DR SMART; SM00282; LamG; 5. DR SMART; SM00136; LamNT; 1. DR SUPFAM; SSF49899; SSF49899; 5. DR PROSITE; PS00022; EGF_1; 1. DR PROSITE; PS01248; EGF_LAM_1; 5. DR PROSITE; PS50027; EGF_LAM_2; 14. DR PROSITE; PS50025; LAM_G_DOMAIN; 5. DR PROSITE; PS51115; LAMININ_IVA; 1. DR PROSITE; PS51117; LAMININ_NTER; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00460, KW ECO:0000256|SAAS:SAAS00814887}; KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460, KW ECO:0000256|SAAS:SAAS00580772}; KW Proteomics identification {ECO:0000213|EPD:A0A0A0MSA0, KW ECO:0000213|MaxQB:A0A0A0MSA0, ECO:0000213|PeptideAtlas:A0A0A0MSA0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00966518}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 36 {ECO:0000256|SAM:SignalP}. FT CHAIN 37 3277 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001967258. FT DOMAIN 43 298 Laminin N-terminal. FT {ECO:0000259|PROSITE:PS51117}. FT DOMAIN 299 355 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 356 425 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 426 469 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 491 535 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 536 588 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 590 630 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 631 683 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 684 728 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 1266 1311 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 1312 1355 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 1356 1404 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 1405 1455 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 1476 1653 Laminin IV type A. FT {ECO:0000259|PROSITE:PS51115}. FT DOMAIN 1687 1733 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 1734 1786 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 2334 2535 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 2542 2704 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 2711 2871 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 2930 3094 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 3101 3274 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT COILED 1853 1936 {ECO:0000256|SAM:Coils}. FT COILED 1965 2006 {ECO:0000256|SAM:Coils}. FT COILED 2042 2076 {ECO:0000256|SAM:Coils}. FT COILED 2079 2113 {ECO:0000256|SAM:Coils}. FT COILED 2269 2289 {ECO:0000256|SAM:Coils}. FT COILED 2307 2327 {ECO:0000256|SAM:Coils}. FT DISULFID 321 330 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 393 402 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 445 454 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 491 503 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 511 520 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 536 548 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 538 555 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 557 566 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 601 610 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 654 663 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 684 696 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 686 703 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 705 714 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1266 1278 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1268 1285 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1287 1296 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1328 1337 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1380 1389 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1405 1417 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1407 1424 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1426 1435 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1706 1715 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1734 1746 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 1757 1766 {ECO:0000256|PROSITE-ProRule:PRU00460}. SQ SEQUENCE 3277 AA; 360182 MW; CACFFE9D7021C943 CRC64; MAAAARPRGR ALGPVLPPTP LLLLVLRVLP ACGATARDPG AAAGLSLHPT YFNLAEAARI WATATCGERG PGEGRPQPEL YCKLVGGPTA PGSGHTIQGQ FCDYCNSEDP RKAHPVTNAI DGSERWWQSP PLSSGTQYNR VNLTLDLGQL FHVAYILIKF ANSPRPDLWV LERSVDFGST YSPWQYFAHS KVDCLKEFGR EANMAVTRDD DVLCVTEYSR IVPLENGEVV VSLINGRPGA KNFTFSHTLR EFTKATNIRL RFLRTNTLLG HLISKAQRDP TVTRRYYYSI KDISIGGQCV CNGHAEVCNI NNPEKLFRCE CQHHTCGETC DRCCTGYNQR RWRPAAWEQS HECEACNCHG HASNCYYDPD VERQQASLNT QGIYAGGGVC INCQHNTAGV NCEQCAKGYY RPYGVPVDAP DGCIPCSCDP EHADGCEQGS GRCHCKPNFH GDNCEKCAIG YYNFPFCLRI PIFPVSTPSS EDPVAGDIKG CDCNLEGVLP EICDAHGRCL CRPGVEGPRC DTCRSGFYSF PICQACWCSA LGSYQMPCSS VTGQCECRPG VTGQRCDRCL SGAYDFPHCQ GSSSACDPAG TINSNLGYCQ CKLHVEGPTC SRCKLLYWNL DKENPSGCSE CKCHKAGTVS GTGECRQGDG DCHCKSHVGG DSCDTCEDGY FALEKSNYFG CQGCQCDIGG ALSSMCSGPS GVCQCREHVV GKVCQRPENN YYFPDLHHMK YEIEDGSTPN GRDLRFGFDP LAFPEFSWRG YAQMTSVQND VRITLNVGKS SGSLFRVILR YVNPGTEAVS GHITIYPSWG AAQSKEIIFL PSKEPAFVTV PGNGFADPFS ITPGIWVACI KAEGVLLDYL VLLPRDYYEA SVLQLPVTEP CAYAGPPQEN CLLYQHLPVT RFPCTLACEA RHFLLDGEPR PVAVRQPTPA HPVMVDLSGR EVELHLRLRI PQVGHYVVVV EYSTEAAQLF VVDVNVKSSG SVLAGQVNIY SCNYSVLCRS AVIDHMSRIA MYELLADADI QLKGHMARFL LHQVCIIPIE EFSAEYVRPQ VHCIASYGRF VNQSATCVSL AHETPPTALI LDVLSGRPFP HLPQQSSPSV DVLPGVTLKA PQNQVTLRGR VPHLGRYVFV IHFYQAAHPT FPAQVSVDGG WPRAGSFHAS FCPHVLGCRD QVIAEGQIEF DISEPEVAAT VKVPEGKSLV LVRVLVVPAE NYDYQILHKK SMDKSLEFIT NCGKNSFYLD PQTASRFCKN SARSLVAFYH KGALPCECHP TGATGPHCSP EGGQCPCQPN VIGRQCTRCA TGHYGFPRCK PCSCGRRLCE EMTGQCRCPP RTVRPQCEVC ETHSFSFHPM AGCEGCNCSR RGTIEAAMPE CDRDSGQCRC KPRITGRQCD RCASGFYRFP ECVPCNCNRD GTEPGVCDPG TGACLCKENV EGTECNVCRE GSFHLDPANL KGCTSCFCFG VNNQCHSSHK RRTKFVDMLG WHLETADRVD IPVSFNPGSN SMVADLQELP ATIHSASWVA PTSYLGDKVS SYGGYLTYQA KSFGLPGDMV LLEKKPDVQL TGQHMSIIYE ETNTPRPDRL HHGRVHVVEG NFRHASSRAP VSREELMTVL SRLADVRIQG LYFTETQRLT LSEVGLEEAS DTGSGRIALA VEICACPPAY AGDSCQGCSP GYYRDHKGLY TGRCVPCNCN GHSNQCQDGS GICVNCQHNT AGEHCERCQE GYYGNAVHGS CRACPCPHTN SFATGCVVNG GDVRCSCKAG YTGTQCERCA PGYFGNPQKF GGSCQPCSCN SNGQLGSCHP LTGDCINQEP KDSSPAEECD DCDSCVMTLL NDLATMGEQL RLVKSQLQGL SASAGLLEQM RHMETQAKDL RNQLLNYRSA ISNHGSKIEG LERELTDLNQ EFETLQEKAQ VNSRKAQTLN NNVNRATQSA KELDVKIKNV IRNVHMLNRI RTWQKTHQGE NNGLANSIRD SLNEYEAKLS DLRARLQEAA AQAKQANGLN QENERALGAI QRQVKEINSL QSDFTKYLTT ADSSLLQTNI ALQLMEKSQK EYEKLAASLN EARQELSDKV RELSRSAGKT SLVEEAEKHA RSLQELAKQL EEIKRNASGD ELVRCAVDAA TAYENILNAI KAAEDAANRA ASASESALQT VIKEDLPRKA KTLSSNSDKL LNEAKMTQKK LKQEVSPALN NLQQTLNIVT VQKEVIDTNL TTLRDGLHGI QRGDIDAMIS SAKSMVRKAN DITDEVLDGL NPIQTDVERI KDTYGRTQNE DFKKALTDAD NSVNKLTNKL PDLWRKIESI NQQLLPLGNI SDNMDRIREL IQQARDAASK VAVPMRFNGK SGVEVRLPND LEDLKGYTSL SLFLQRPNSR ENGGTENMFV MYLGNKDASR DYIGMAVVDG QLTCVYNLGD REAELQVDQI LTKSETKEAV MDRVKFQRIY QFARLNYTKG ATSSKPETPG VYDMDGRNSN TLLNLDPENV VFYVGGYPPD FKLPSRLSFP PYKGCIELDD LNENVLSLYN FKKTFNLNTT EVEPCRRRKE ESDKNYFEGT GYARVPTQPH APIPTFGQTI QTTVDRGLLF FAENGDRFIS LNIEDGKLMV RYKLNSELPK ERGVGDAINN GRDHSIQIKI GKLQKRMWIN VDVQNTIIDG EVFDFSTYYL GGIPIAIRER FNISTPAFRG CMKNLKKTSG VVRLNDTVGV TKKCSEDWKL VRSASFSRGG QLSFTDLGLP PTDHLQASFG FQTFQPSGIL LDHQTWTRNL QVTLEDGYIE LSTSDSGGPI FKSPQTYMDG LLHYVSVISD NSGLRLLIDD QLLRNSKRLK HISSSRQSLR LGGSNFEGCI SNVFVQRLSL SPEVLDLTSN SLKRDVSLGG CSLNKPPFLM LLKGSTRFNK TKTFRINQLL QDTPVASPRS VKVWQDACSP LPKTQANHGA LQFGDIPTSH LLFKLPQELL KPRSQFAVDM QTTSSRGLVF HTGTKNSFMA LYLSKGRLVF ALGTDGKKLR IKSKEKCNDG KWHTVVFGHD GEKGRLVVDG LRAREGSLPG NSTISIRAPV YLGSPPSGKP KSLPTNSFVG CLKNFQLDSK PLYTPSSSFG VSSCLGGPLE KGIYFSEEGG HVVLAHSVLL GPEFKLVFSI RPRSLTGILI HIGSQPGKHL CVYLEAGKVT ASMDSGAGGT STSVTPKQSL CDGQWHSVAV TIKQHILHLE LDTDSSYTAG QIPFPPASTQ EPLHLGGAPA NLTTLRIPVW KSFFGCLRNI HVNHIPVPVT EALEVQGPVS LNGCPDQ //