ID A0A0A0MS64_HUMAN Unreviewed; 1140 AA. AC A0A0A0MS64; DT 07-JAN-2015, integrated into UniProtKB/TrEMBL. DT 07-JAN-2015, sequence version 1. DT 16-JAN-2019, entry version 34. DE SubName: Full=Multiple epidermal growth factor-like domains protein 11 {ECO:0000313|Ensembl:ENSP00000378976}; GN Name=MEGF11 {ECO:0000313|Ensembl:ENSP00000378976}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000378976, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000378976, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16572171; DOI=10.1038/nature04601; RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S., RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., RA Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., RA Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., RA Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., RA Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., RA Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., RA Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., RA Nusbaum C.; RT "Analysis of the DNA sequence and duplication history of human RT chromosome 15."; RL Nature 440:671-675(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000378976} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2014) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC011847; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC084854; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC087382; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456072; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A0A0MS64; -. DR jPOST; A0A0A0MS64; -. DR Ensembl; ENST00000395614; ENSP00000378976; ENSG00000157890. DR UCSC; uc059klo.1; human. DR EuPathDB; HostDB:ENSG00000157890.17; -. DR HGNC; HGNC:29635; MEGF11. DR OpenTargets; ENSG00000157890; -. DR eggNOG; KOG1218; Eukaryota. DR eggNOG; ENOG410XQWV; LUCA. DR GeneTree; ENSGT00940000155333; -. DR ChiTaRS; MEGF11; human. DR Proteomes; UP000005640; Chromosome 15. DR Bgee; ENSG00000157890; Expressed in 121 organ(s), highest expression level in cerebellum. DR ExpressionAtlas; A0A0A0MS64; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR011489; EMI_domain. DR InterPro; IPR002049; Laminin_EGF. DR Pfam; PF12661; hEGF; 3. DR Pfam; PF00053; Laminin_EGF; 8. DR SMART; SM00181; EGF; 17. DR SMART; SM00180; EGF_Lam; 16. DR PROSITE; PS00022; EGF_1; 14. DR PROSITE; PS01186; EGF_2; 2. DR PROSITE; PS50026; EGF_3; 14. DR PROSITE; PS50027; EGF_LAM_2; 8. DR PROSITE; PS51041; EMI; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00460}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076}; KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00580781}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 1140 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001967097. FT TRANSMEM 849 871 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 24 101 EMI. {ECO:0000259|PROSITE:PS51041}. FT DOMAIN 95 130 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 143 173 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 146 187 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 181 216 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 189 236 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 224 259 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 267 302 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 275 322 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 310 345 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 362 405 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 399 434 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 442 477 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 450 495 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 490 520 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 536 583 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 571 606 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 622 665 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 659 694 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 707 737 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 750 780 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 753 794 Laminin EGF-like. FT {ECO:0000259|PROSITE:PS50027}. FT DOMAIN 788 823 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DISULFID 120 129 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 163 172 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 206 215 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 249 258 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 292 301 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 335 344 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 381 390 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 424 433 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 467 476 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 510 519 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 553 562 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 596 605 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 641 650 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 684 693 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 727 736 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 770 779 {ECO:0000256|PROSITE-ProRule:PRU00460}. FT DISULFID 813 822 {ECO:0000256|PROSITE-ProRule:PRU00076}. SQ SEQUENCE 1140 AA; 121418 MW; B326B6362B9D82CD CRC64; MVLSLTGLIA FSFLQATLAL NPEDPNVCSH WESYAVTVQE SYAHPFDQIY YTRCTDILNW FKCTRHRISY KTAYRRGLRT MYRRRSQCCP GYYESGDFCI PLCTEECVHG RCVSPDTCHC EPGWGGPDCS SGCDSDHWGP HCSNRCQCQN GALCNPITGA CVCAAGFRGW RCEELCAPGT HGKGCQLPCQ CRHGASCDPR AGECLCAPGY TGVYCEELCP PGSHGAHCEL RCPCQNGGTC HHITGECACP PGWTGAVCAQ PCPPGTFGQN CSQDCPCHHG GQCDHVTGQC HCTAGYMGDR CQEECPFGSF GFQCSQHCDC HNGGQCSPTT GACECEPGYK GPRCQERLCP EGLHGPGCTL PCPCDADNTI SCHPVTGACT CQPGWSGHHC NESCPVGYYG DGCQLPCTCQ NGADCHSITG GCTCAPGFMG EVCAVSCAAG TYGPNCSSIC SCNNGGTCSP VDGSCTCKEG WQGLDCTLPC PSGTWGLNCN ESCTCANGAA CSPIDGSCSC TPGWLGDTCE LPCPDGTFGL NCSEHCDCSH ADGCDPVTGH CCCLAGWTGI RCDSTCPPGR WGPNCSVSCS CENGGSCSPE DGSCECAPGF RGPLCQRICP PGFYGHGCAQ PCPLCVHSSR PCHHISGICE CLPGFSGALC NQVCAGGYFG QDCAQLCSCA NNGTCSPIDG SCQCFPGWIG KDCSQACPPG FWGPACFHAC SCHNGASCSA EDGACHCTPG WTGLFCTQRC PAAFFGKDCG RVCQCQNGAS CDHISGKCTC RTGFTGQHCE QRCAPGTFGY GCQQLCECMN NSTCDHVTGT CYCSPGFKGI RCDQAALMME ELNPYTKISP ALGAERHSVG AVTGIMLLLF LIVVLLGLFA WHRRRQKEKG RDLAPRVSYT PAMRMTSTDY SLSDLSQSSS HAHCFSNSSY HALACGGPAT SQASTLDRNS PTKLSNKSLD RDTAGWTPYS YVNVLDSHFQ ISALEARYPP EDFYIELRHL SRPAEPHSPG ACGMDRRQNT YIMDKGFKDY MKESVCSSST CSLNSSENPY ATIKDPPILT CKLPESSYVE MKSPVHMGSP YTDVPSLSTS NKNIYEVEPT VSVVQEGCGH NSSYIQNAYD LPRNSHIPGH YDLLPVRQSP ANGPSQDKQS //