ID   A0A0A0MRJ7_HUMAN        Unreviewed;      2229 AA.
AC   A0A0A0MRJ7;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   16-JAN-2019, entry version 40.
DE   SubName: Full=Coagulation factor V {ECO:0000313|Ensembl:ENSP00000356770};
GN   Name=F5 {ECO:0000313|Ensembl:ENSP00000356770};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000356770, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000356770, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000213|PubMed:18088087}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18088087; DOI=10.1021/pr0704130;
RA   Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,
RA   Schutz C., Walter U., Gambaryan S., Sickmann A.;
RT   "Phosphoproteome of resting human platelets.";
RL   J. Proteome Res. 7:526-534(2008).
RN   [3] {ECO:0000213|PubMed:19690332}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:ra46-RA46(2009).
RN   [4] {ECO:0000313|Ensembl:ENSP00000356770}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the multicopper oxidase family.
CC       {ECO:0000256|SAAS:SAAS00534212}.
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DR   EMBL; KF495727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; Z99572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A0A0MRJ7; -.
DR   jPOST; A0A0A0MRJ7; -.
DR   Ensembl; ENST00000367796; ENSP00000356770; ENSG00000198734.
DR   UCSC; uc057neb.1; human.
DR   EuPathDB; HostDB:ENSG00000198734.10; -.
DR   HGNC; HGNC:3542; F5.
DR   OpenTargets; ENSG00000198734; -.
DR   eggNOG; ENOG410IJ6Y; Eukaryota.
DR   eggNOG; ENOG4111F6G; LUCA.
DR   GeneTree; ENSGT00940000158556; -.
DR   OMA; TEVGENQ; -.
DR   ChiTaRS; F5; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000198734; Expressed in 160 organ(s), highest expression level in right lobe of liver.
DR   ExpressionAtlas; A0A0A0MRJ7; baseline and differential.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   CDD; cd00057; FA58C; 2.
DR   Gene3D; 2.60.120.260; -; 2.
DR   Gene3D; 2.60.40.420; -; 5.
DR   InterPro; IPR011707; Cu-oxidase_3.
DR   InterPro; IPR033138; Cu_oxidase_CS.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR024715; Factor_5/8_like.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   Pfam; PF07732; Cu-oxidase_3; 2.
DR   Pfam; PF00754; F5_F8_type_C; 2.
DR   PIRSF; PIRSF000354; Factors_V_VIII; 1.
DR   SMART; SM00231; FA58C; 2.
DR   SUPFAM; SSF49503; SSF49503; 6.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   PROSITE; PS01285; FA58C_1; 2.
DR   PROSITE; PS01286; FA58C_2; 2.
DR   PROSITE; PS50022; FA58C_3; 2.
DR   PROSITE; PS00079; MULTICOPPER_OXIDASE1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR000354-1};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00524516};
KW   Proteomics identification {ECO:0000213|EPD:A0A0A0MRJ7,
KW   ECO:0000213|MaxQB:A0A0A0MRJ7, ECO:0000213|PeptideAtlas:A0A0A0MRJ7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29   2229       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001967227.
FT   DOMAIN     1912   2066       F5/8 type C.
FT                                {ECO:0000259|PROSITE:PS50022}.
FT   DOMAIN     2071   2226       F5/8 type C.
FT                                {ECO:0000259|PROSITE:PS50022}.
FT   DISULFID    167    193       {ECO:0000256|PIRSR:PIRSR000354-1}.
FT   DISULFID    248    329       {ECO:0000256|PIRSR:PIRSR000354-1}.
FT   DISULFID    500    526       {ECO:0000256|PIRSR:PIRSR000354-1}.
FT   DISULFID    608    689       {ECO:0000256|PIRSR:PIRSR000354-1}.
FT   DISULFID   1730   1756       {ECO:0000256|PIRSR:PIRSR000354-1}.
FT   DISULFID   1912   2066       {ECO:0000256|PIRSR:PIRSR000354-1}.
SQ   SEQUENCE   2229 AA;  252236 MW;  C7DC50395B44292C CRC64;
     MFPGCPRLWV LVVLGTSWVG WGSQGTEAAQ LRQFYVAAQG ISWSYRPEPT NSSLNLSVTS
     FKKIVYREYE PYFKKEKPQS TISGLLGPTL YAEVGDIIKV HFKNKADKPL SIHPQGIRYS
     KLSEGASYLD HTFPAEKMDD AVAPGREYTY EWSISEDSGP THDDPPCLTH IYYSHENLIE
     DFNSGLIGPL LICKKGTLTE GGTQKTFDKQ IVLLFAVFDE SKSWSQSSSL MYTVNGYVNG
     TMPDITVCAH DHISWHLLGM SSGPELFSIH FNGQVLEQNH HKVSAITLVS ATSTTANMTV
     GPEGKWIISS LTPKHLQAGM QAYIDIKNCP KKTRNLKKIT REQRRHMKRW EYFIAAEEVI
     WDYAPVIPAN MDKKYRSQHL DNFSNQIGKH YKKVMYTQYE DESFTKHTVN PNMKEDGILG
     PIIRAQVRDT LKIVFKNMAS RPYSIYPHGV TFSPYEDEVN SSFTSGRNNT MIRAVQPGET
     YTYKWNILEF DEPTENDAQC LTRPYYSDVD IMRDIASGLI GLLLICKSRS LDRRGIQRAA
     DIEQQAVFAV FDENKSWYLE DNINKFCENP DEVKRDDPKF YESNIMSNFT LSAINGYVPE
     SITTLGFCFD DTVQWHFCSV GTQNEILTIH FTGHSFIYGK RHEDTLTLFP MRGESVTVTM
     DNVGTWMLTS MNSSPRSKKL RLKFRDVKCI PDDDEDSYEI FEPPESTVMA TRKMHDRLEP
     EDEESDADYD YQNRLAAALG IRSFRNSSLN QEEEEFNLTA LALENGTEFV SSNTDIIVGS
     NYSSPSNISK FTVNNLAEPQ KAPSHQQATT AGSPLRHLIG KNSVLNSSTA EHSSPYSEDP
     IEDPLQPDVT GIRLLSLGAG EFKSQEHAKH KGPKVERDQA AKHRFSWMKL LAHKVGRHLS
     QDTGSPSGMR PWEDLPSQDT GSPSRMRPWK DPPSDLLLLK QSNSSKILVG RWHLASEKGS
     YEIIQDTDED TAVNNWLISP QNASRAWGES TPLANKPGKQ SGHPKFPRVR HKSLQVRQDG
     GKSRLKKSQF LIKTRKKKKE KHTHHAPLSP RTFHPLRSEA YNTFSERRLK HSLVLHKSNE
     TSLPTDLNQT LPSMDFGWIA SLPDHNQNSS NDTGQASCPP GLYQTVPPEE HYQTFPIQDP
     DQMHSTSDPS HRSSSPELSE MLEYDRSHKS FPTDISQMSP SSEHEVWQTV ISPDLSQVTL
     SPELSQTNLS PDLSHTTLSP ELIQRNLSPA LGQMPISPDL SHTTLSPDLS HTTLSLDLSQ
     TNLSPELSQT NLSPALGQMP LSPDLSHTTL SLDFSQTNLS PELSHMTLSP ELSQTNLSPA
     LGQMPISPDL SHTTLSLDFS QTNLSPELSQ TNLSPALGQM PLSPDPSHTT LSLDLSQTNL
     SPELSQTNLS PDLSEMPLFA DLSQIPLTPD LDQMTLSPDL GETDLSPNFG QMSLSPDLSQ
     VTLSPDISDT TLLPDLSQIS PPPDLDQIFY PSESSQSLLL QEFNESFPYP DLGQMPSPSS
     PTLNDTFLSK EFNPLVIVGL SKDGTDYIEI IPKEEVQSSE DDYAEIDYVP YDDPYKTDVR
     TNINSSRDPD NIAAWYLRSN NGNRRNYYIA AEEISWDYSE FVQRETDIED SDDIPEDTTY
     KKVVFRKYLD STFTKRDPRG EYEEHLGILG PIIRAEVDDV IQVRFKNLAS RPYSLHAHGL
     SYEKSSEGKT YEDDSPEWFK EDNAVQPNSS YTYVWHATER SGPESPGSAC RAWAYYSAVN
     PEKDIHSGLI GPLLICQKGI LHKDSNMPMD MREFVLLFMT FDEKKSWYYE KKSRSSWRLT
     SSEMKKSHEF HAINGMIYSL PGLKMYEQEW VRLHLLNIGG SQDIHVVHFH GQTLLENGNK
     QHQLGVWPLL PGSFKTLEMK ASKPGWWLLN TEVGENQRAG MQTPFLIMDR DCRMPMGLST
     GIISDSQIKA SEFLGYWEPR LARLNNGGSY NAWSVEKLAA EFASKPWIQV DMQKEVIITG
     IQTQGAKHYL KSCYTTEFYV AYSSNQINWQ IFKGNSTRNV MYFNGNSDAS TIKENQFDPP
     IVARYIRISP TRAYNRPTLR LELQGCEVNG CSTPLGMENG KIENKQITAS SFKKSWWGDY
     WEPFRARLNA QGRVNAWQAK ANNNKQWLEI DLLKIKKITA IITQGCKSLS SEMYVKSYTI
     HYSEQGVEWK PYRLKSSMVD KIFEGNTNTK GHVKNFFNPP IISRFIRVIP KTWNQSIALR
     LELFGCDIY
//