ID   A0A0A0MRC1_HUMAN        Unreviewed;       583 AA.
AC   A0A0A0MRC1;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   16-JAN-2019, entry version 31.
DE   SubName: Full=Kin of IRRE-like protein 2 {ECO:0000313|Ensembl:ENSP00000345067};
GN   Name=KIRREL2 {ECO:0000313|Ensembl:ENSP00000345067};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000345067, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000345067, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000345067}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
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DR   EMBL; AC002133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AD000864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_954648.3; NM_199179.3.
DR   UniGene; Hs.145729; -.
DR   ProteinModelPortal; A0A0A0MRC1; -.
DR   PRIDE; A0A0A0MRC1; -.
DR   Ensembl; ENST00000347900; ENSP00000345067; ENSG00000126259.
DR   GeneID; 84063; -.
DR   UCSC; uc002oca.5; human.
DR   CTD; 84063; -.
DR   EuPathDB; HostDB:ENSG00000126259.19; -.
DR   HGNC; HGNC:18816; KIRREL2.
DR   OpenTargets; ENSG00000126259; -.
DR   GeneTree; ENSGT00940000160603; -.
DR   OrthoDB; 269917at2759; -.
DR   ChiTaRS; KIRREL2; human.
DR   GenomeRNAi; 84063; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000126259; Expressed in 66 organ(s), highest expression level in body of pancreas.
DR   ExpressionAtlas; A0A0A0MRC1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 5.
DR   InterPro; IPR013162; CD80_C2-set.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   Pfam; PF08205; C2-set_2; 1.
DR   SMART; SM00409; IG; 5.
DR   SMART; SM00408; IGc2; 2.
DR   SUPFAM; SSF48726; SSF48726; 5.
DR   PROSITE; PS50835; IG_LIKE; 4.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00504776};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS01086444};
KW   Membrane {ECO:0000256|SAAS:SAAS00555568, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00289622};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00555568,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00555568,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    583       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001967217.
FT   TRANSMEM    461    484       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       73    172       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      177    257       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      262    344       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      348    451       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   583 AA;  61761 MW;  D9A1A837AF8E78CC CRC64;
     MLRMRVPALL VLLFCFRGRA GWSRYWISGN AANGQHDLHI RPVELEDEAS YECQATQAGL
     RSRPAQLHVL VPPEAPQVLG GPSVSLVAGV PANLTCRSRG DARPTPELLW FRDGVLLDGA
     TFHQTLLKEG TPGSVESTLT LTPFSHDDGA TFVCRARSQA LPTGRDTAIT LSLQYPPEVT
     LSASPHTVQE GEKVIFLCQA TAQPPVTGYR WAKGGSPVLG ARGPRLEVVA DASFLTEPVS
     CEVSNAVGSA NRSTALDVLF GPILQAKPEP VSVDVGEDAS FSCAWRGNPL PRVTWTRRGG
     AQVLGSGATL RLPSVGPEDA GDYVCRAEAG LSGLRGGAAE ARLTVNAPPV VTALHSAPAF
     LRGPARLQCL VFASPAPDAV VWSWDEGFLE AGSQGRFLVE TFPAPESRGG LGPGLISVLH
     ISGTQESDFS RSFNCSARNR LGEGGAQASL GRRDLLPTVR IVAGVAAATT TLLMVITGVA
     LCCWRHSKAS ASFSEQKNLM RIPGSSDGSS SRGPEEEETG SREDRGPIVH TDHSDLVLEE
     EGTLETKDPT NGYYKVRGVS PPASPDSRVT SFQWKSPGIS NLP
//