ID   A0A0A0MR61_HUMAN        Unreviewed;       282 AA.
AC   A0A0A0MR61;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   05-DEC-2018, entry version 31.
DE   SubName: Full=Serine protease 57 {ECO:0000313|Ensembl:ENSP00000327386};
GN   Name=PRSS57 {ECO:0000313|Ensembl:ENSP00000327386};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000327386, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000327386, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000327386}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|SAAS:SAAS00559343}.
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DR   EMBL; AC004156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC112708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A0A0MR61; -.
DR   PRIDE; A0A0A0MR61; -.
DR   Ensembl; ENST00000329267; ENSP00000327386; ENSG00000185198.
DR   UCSC; uc010xfs.2; human.
DR   EuPathDB; HostDB:ENSG00000185198.11; -.
DR   HGNC; HGNC:31397; PRSS57.
DR   OpenTargets; ENSG00000185198; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00940000162457; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000185198; Expressed in 26 organ(s), highest expression level in blood.
DR   ExpressionAtlas; A0A0A0MR61; baseline and differential.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00037407};
KW   Proteomics identification {ECO:0000213|EPD:A0A0A0MR61,
KW   ECO:0000213|MaxQB:A0A0A0MR61, ECO:0000213|PeptideAtlas:A0A0A0MR61};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     30       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        31    282       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001967205.
FT   DOMAIN       33    262       Peptidase S1.
FT                                {ECO:0000259|PROSITE:PS50240}.
SQ   SEQUENCE   282 AA;  30263 MW;  E1AB18B8E8F6F1C0 CRC64;
     MGLGLRGWGR PLLTVATALM LPVKPPGSWG AQIIGGHEVT PHSRPYMASV RFGGQHHCGG
     FLLRARWVVS AAHCFSHRDL RTGLVVLGAH VLSTAEPTQQ VFGIDALTTH PDYHPMTHAN
     DICLLRLNGS AVLGPAVGLL RPPGRRARPP TAGTRCRVAG WGFVSDFEEL PPGLMEAKVR
     VLDPDVCNSS WKGHLTLTML CTRSGDSHRR GFCSADSGGP LVCRNRAHGL VSFSGLWCGD
     PKTPDVYTQV SAFVAWIWDV VRRSSPQPGP LPGTTRPPGE AA
//