ID   A0A0A0MR60_HUMAN        Unreviewed;      1505 AA.
AC   A0A0A0MR60;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   13-FEB-2019, entry version 38.
DE   SubName: Full=Receptor-type tyrosine-protein phosphatase S {ECO:0000313|Ensembl:ENSP00000327313};
GN   Name=PTPRS {ECO:0000313|Ensembl:ENSP00000327313};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000327313, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000327313, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000327313}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein]
CC         + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48;
CC         Evidence={ECO:0000256|SAAS:SAAS01128831};
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DR   EMBL; AC005335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC022517; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC118535; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_570925.2; NM_130855.2.
DR   RefSeq; XP_016882565.1; XM_017027076.1.
DR   UniGene; Hs.744928; -.
DR   ProteinModelPortal; A0A0A0MR60; -.
DR   jPOST; A0A0A0MR60; -.
DR   PRIDE; A0A0A0MR60; -.
DR   Ensembl; ENST00000353284; ENSP00000327313; ENSG00000105426.
DR   GeneID; 5802; -.
DR   UCSC; uc002mbx.3; human.
DR   CTD; 5802; -.
DR   EuPathDB; HostDB:ENSG00000105426.14; -.
DR   HGNC; HGNC:9681; PTPRS.
DR   OpenTargets; ENSG00000105426; -.
DR   eggNOG; KOG4228; Eukaryota.
DR   eggNOG; COG5599; LUCA.
DR   GeneTree; ENSGT00940000153617; -.
DR   OrthoDB; 220353at2759; -.
DR   ChiTaRS; PTPRS; human.
DR   GenomeRNAi; 5802; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000105426; Expressed in 203 organ(s), highest expression level in forebrain.
DR   ExpressionAtlas; A0A0A0MR60; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   CDD; cd00063; FN3; 4.
DR   Gene3D; 2.60.40.10; -; 7.
DR   Gene3D; 3.90.190.10; -; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTPase_domain.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; TYR_PHOSPHATASE_dom.
DR   Pfam; PF00041; fn3; 3.
DR   Pfam; PF07679; I-set; 3.
DR   Pfam; PF00102; Y_phosphatase; 2.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00060; FN3; 4.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 3.
DR   SMART; SM00194; PTPc; 2.
DR   SMART; SM00404; PTPc_motif; 2.
DR   SUPFAM; SSF48726; SSF48726; 3.
DR   SUPFAM; SSF49265; SSF49265; 2.
DR   SUPFAM; SSF52799; SSF52799; 2.
DR   PROSITE; PS50853; FN3; 4.
DR   PROSITE; PS50835; IG_LIKE; 3.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01031415};
KW   Membrane {ECO:0000256|SAAS:SAAS00897767, ECO:0000256|SAM:Phobius};
KW   Protein phosphatase {ECO:0000256|SAAS:SAAS01031415};
KW   Proteomics identification {ECO:0000213|EPD:A0A0A0MR60,
KW   ECO:0000213|MaxQB:A0A0A0MR60, ECO:0000213|PeptideAtlas:A0A0A0MR60};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00923712};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00897767,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00897767,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     29       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        30   1505       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001974411.
FT   TRANSMEM    856    879       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       33    123       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      135    224       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      236    318       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      325    415       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      420    514       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      518    607       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      609    693       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      950   1205       Tyrosine-protein phosphatase.
FT                                {ECO:0000259|PROSITE:PS50055}.
FT   DOMAIN     1125   1196       TYR_PHOSPHATASE_2.
FT                                {ECO:0000259|PROSITE:PS50056}.
FT   DOMAIN     1237   1496       Tyrosine-protein phosphatase.
FT                                {ECO:0000259|PROSITE:PS50055}.
FT   DOMAIN     1414   1487       TYR_PHOSPHATASE_2.
FT                                {ECO:0000259|PROSITE:PS50056}.
FT   COILED      754    774       {ECO:0000256|SAM:Coils}.
FT   ACT_SITE   1146   1146       Phosphocysteine intermediate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00160}.
FT   ACT_SITE   1437   1437       Phosphocysteine intermediate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00160}.
SQ   SEQUENCE   1505 AA;  168921 MW;  E10A30D4B93B0DDC CRC64;
     MAPTWGPGMV SVVGPMGLLV VLLVGGCAAE EPPRFIKEPK DQIGVSGGVA SFVCQATGDP
     KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR DENVYECVAQ NSVGEITVHA
     KLTVLREDQL PSGFPNIDMG PQLKVVERTR TATMLCAASG NPDPEITWFK DFLPVDPSAS
     NGRIKQLRSG ALQIESSEET DQGKYECVAT NSAGVRYSSP ANLYVRELRE VRRVAPRFSI
     LPMSHEIMPG GNVNITCVAV GSPMPYVKWM QGAEDLTPED DMPVGRNVLE LTDVKDSANY
     TCVAMSSLGV IEAVAQITVK SLPKAPGTPM VTENTATSIT ITWDSGNPDP VSYYVIEYKS
     KSQDGPYQIK EDITTTRYSI GGLSPNSEYE IWVSAVNSIG QGPPSESVVT RTGEQAPASA
     PRNVQARMLS ATTMIVQWEE PVEPNGLIRG YRVYYTMEPE HPVGNWQKHN VDDSLLTTVG
     SLLEDETYTV RVLAFTSVGD GPLSDPIQVK TQQGVPGQPM NLRAEARSET SITLSWSPPR
     QESIIKYELL FREGDHGREV GRTFDPTTSY VVEDLKPNTE YAFRLAARSP QGLGAFTPVV
     RQRTLQSISP KNFKVKMIMK TSVLLSWEFP DNYNSPTPYK IQYNGLTLDV DGRTTKKLIT
     HLKPHTFYNF VLTNRGSSLG GLQQTVTAWT AFNLLNGKPS VAPKPDADGF IMVYLPDGQS
     PVPVQSYFIV MVPLRKSRGG QFLTPLGSPE DMDLEELIQD ISRLQRRSLR HSRQLEVPRP
     YIAARFSVLP PTFHPGDQKQ YGGFDNRGLE PGHRYVLFVL AVLQKSEPTF AASPFSDPFQ
     LDNPDPQPIV DGEEGLIWVI GPVLAVVFII CIVIAILLYK NKPDSKRKDS EPRTKCLLNN
     ADLAPHHPKD PVEMRRINFQ TPGMLSHPPI PIADMAEHTE RLKANDSLKL SQEYESIDPG
     QQFTWEHSNL EVNKPKNRYA NVIAYDHSRV ILQPIEGIMG SDYINANYVD GYRCQNAYIA
     TQGPLPETFG DFWRMVWEQR SATIVMMTRL EEKSRIKCDQ YWPNRGTETY GFIQVTLLDT
     IELATFCVRT FSLHKNGSSE KREVRQFQFT AWPDHGVPEY PTPFLAFLRR VKTCNPPDAG
     PIVVHCSAGV GRTGCFIVID AMLERIKPEK TVDVYGHVTL MRSQRNYMVQ TEDQYSFIHE
     ALLEAVGCGN TEVPARSLYA YIQKLAQVEP GEHVTGMELE FKRLANSKAH TSRFISANLP
     CNKFKNRLVN IMPYESTRVC LQPIRGVEGS DYINASFIDG YRQQKAYIAT QGPLAETTED
     FWRMLWENNS TIVVMLTKLR EMGREKCHQY WPAERSARYQ YFVVDPMAEY NMPQYILREF
     KVTDARDGQS RTVRQFQFTD WPEQGVPKSG EGFIDFIGQV HKTKEQFGQD GPISVHCSAG
     VGRTGVFITL SIVLERMRYE GVVDIFQTVK MLRTQRPAMV QTEDEYQFCY QAALEYLGSF
     DHYAT
//