ID   A0A0A0MR20_HUMAN        Unreviewed;      1308 AA.
AC   A0A0A0MR20;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   16-JAN-2019, entry version 41.
DE   SubName: Full=Contactin-associated protein-like 4 {ECO:0000313|Ensembl:ENSP00000306893};
GN   Name=CNTNAP4 {ECO:0000313|Ensembl:ENSP00000306893};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000306893, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000306893, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000306893}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   EMBL; AC010528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC106741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FO681478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A0A0MR20; -.
DR   jPOST; A0A0A0MR20; -.
DR   Ensembl; ENST00000307431; ENSP00000306893; ENSG00000152910.
DR   UCSC; uc059xid.1; human.
DR   EuPathDB; HostDB:ENSG00000152910.18; -.
DR   HGNC; HGNC:18747; CNTNAP4.
DR   OpenTargets; ENSG00000152910; -.
DR   eggNOG; KOG3516; Eukaryota.
DR   eggNOG; ENOG410XPHG; LUCA.
DR   GeneTree; ENSGT00940000157674; -.
DR   ChiTaRS; CNTNAP4; human.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000152910; Expressed in 96 organ(s), highest expression level in C1 segment of cervical spinal cord.
DR   ExpressionAtlas; A0A0A0MR20; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd00057; FA58C; 1.
DR   Gene3D; 2.60.120.260; -; 1.
DR   InterPro; IPR028875; CASPR4.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR036056; Fibrinogen-like_C.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   PANTHER; PTHR43925:SF2; PTHR43925:SF2; 1.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   Pfam; PF02210; Laminin_G_2; 4.
DR   SMART; SM00181; EGF; 2.
DR   SMART; SM00231; FA58C; 1.
DR   SMART; SM00282; LamG; 4.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF49899; SSF49899; 4.
DR   SUPFAM; SSF56496; SSF56496; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01285; FA58C_1; 1.
DR   PROSITE; PS01286; FA58C_2; 1.
DR   PROSITE; PS50022; FA58C_3; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 4.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00122,
KW   ECO:0000256|SAAS:SAAS00814887};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0A0MR20};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00966518};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26   1308       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001967079.
FT   TRANSMEM   1241   1265       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       31    177       F5/8 type C.
FT                                {ECO:0000259|PROSITE:PS50022}.
FT   DOMAIN      183    364       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      370    547       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      549    586       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      585    636       Fibrinogen C-terminal.
FT                                {ECO:0000259|PROSITE:PS51406}.
FT   DOMAIN      793    958       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      959    997       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     1009   1202       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DISULFID    931    958       {ECO:0000256|PROSITE-ProRule:PRU00122}.
SQ   SEQUENCE   1308 AA;  145302 MW;  EC879732BD2E41BD CRC64;
     MGSVTGAVLK TLLLLSTQNW NRVEAGNSYD CDDPLVSALP QASFSSSSEL SSSHGPGFAR
     LNRRDGAGGW SPLVSNKYQW LQIDLGERME VTAVATQGGY GSSNWVTSYL LMFSDSGWNW
     KQYRQEDSIW GFSGNANADS VVYYRLQPSI KARFLRFIPL EWNPKGRIGM RIEVFGCAYR
     SEVVDLDGKS SLLYRFDQKS LSPIKDIISL KFKTMQSDGI LLHREGPNGD HITLQLRRAR
     LFLLINSGEA KLPSTSTLVN LTLGSLLDDQ HWHSVLIQRL GKQVNFTVDE HRHHFHARGE
     FNLMNLDYEI SFGGIPAPGK SVSFPHRNFH GCLENLYYNG VDIIDLAKQQ KPQIIAMGNV
     SFSCSQPQSM PVTFLSSRSY LALPDFSGEE EVSATFQFRT WNKAGLLLFS ELQLISGGIL
     LFLSDGKLKS NLYQPGKLPS DITAGVELND GQWHSVSLSA KKNHLSVAVD GQMASAAPLL
     GPEQIYSGGT YYFGGCPDKS FGSKCKSPLG GFQGCMRLIS ISGKVVDLIS VQQGSLGNFS
     DLQIDSCGIS DRCLPNYCEH GGECSQSWST FHCNCTNTGY RGATCHNSIY EQSCEAYKHR
     GNTSGFYYID SDGSGPLEPF LLYCNMTETA WTIIQHNGSD LTRVRNTNPE NPYAGFFEYV
     ASMEQLQATI NRAEHCEQEF TYYCKKSRLV NKQDGTPLSW WVGRTNETQT YWGGSSPDLQ
     KCTCGLEGNC IDSQYYCNCD ADRNEWTNDT GLLAYKEHLP VTKIVITDTG RLHSEAAYKL
     GPLLCQGDRS FWNSASFDTE ASYLHFPTFH GELSADVSFF FKTTASSGVF LENLGIADFI
     RIELRSPTVV TFSFDVGNGP FEISVQSPTH FNDNQWHHVR VERNMKEASL QVDQLTPKTQ
     PAPADGHVLL QLNSQLFVGG TATRQRGFLG CIRSLQLNGM TLDLEERAQV TPEVQPGCRG
     HCSSYGKLCR NGGKCRERPI GFFCDCTFSA YTGPFCSNEI SAYFGSGSSV IYNFQENYLL
     SKNSSSHAAS FHGDMKLSRE MIKFSFRTTR TPSLLLFVSS FYKEYLSVII AKNGDLQIRY
     KLNKYQEPDV VNFDFKNMAD GQLHHIMINR EEGVVFIEID DNRRRQVHLS SGTEFSAVKS
     LVLGRILEHS DVDQDTALAG AQGFTGCLSA VQLSHVAPLK AALHPSHPDP VTVTGHVTES
     SCMAQPGTDA TSRERTHSFA DHSGTIDDRE PLANAIKSDS AVIGGLIAVV IFILLCITAI
     AVRIYQQKRL YKRSEAKRSE NVDSAEAVLK SELNIQNAVN ENQKEYFF
//