ID A0A0A0MQZ1_HUMAN Unreviewed; 430 AA. AC A0A0A0MQZ1; DT 07-JAN-2015, integrated into UniProtKB/TrEMBL. DT 07-JAN-2015, sequence version 1. DT 05-DEC-2018, entry version 36. DE SubName: Full=Corticotropin-releasing factor receptor 1 {ECO:0000313|Ensembl:ENSP00000293493}; GN Name=CRHR1 {ECO:0000313|Ensembl:ENSP00000293493}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000293493, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000293493, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16625196; DOI=10.1038/nature04689; RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.; RT "DNA sequence of human chromosome 17 and analysis of rearrangement in RT the human lineage."; RL Nature 440:1045-1049(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000293493} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2014) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSP00000479052} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. CC {ECO:0000256|SAAS:SAAS00547938}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC217770; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC217771; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC243621; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000293493; ENSP00000293493; ENSG00000120088. DR Ensembl; ENST00000614143; ENSP00000479052; ENSG00000278232. DR Ensembl; ENST00000616225; ENSP00000480241; ENSG00000276191. DR UCSC; uc060gix.1; human. DR EuPathDB; HostDB:ENSG00000120088.14; -. DR HGNC; HGNC:2357; CRHR1. DR OpenTargets; ENSG00000120088; -. DR eggNOG; KOG4564; Eukaryota. DR eggNOG; ENOG410XRS2; LUCA. DR GeneTree; ENSGT00940000158410; -. DR ChiTaRS; CRHR1; human. DR Proteomes; UP000005640; Chromosome 17. DR Bgee; ENSG00000120088; Expressed in 63 organ(s), highest expression level in pituitary gland. DR ExpressionAtlas; A0A0A0MQZ1; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro. DR CDD; cd15445; 7tmB1_CRF-R1; 1. DR Gene3D; 4.10.1240.10; -; 1. DR InterPro; IPR017981; GPCR_2-like. DR InterPro; IPR003052; GPCR_2_CRF1_rcpt. DR InterPro; IPR003051; GPCR_2_CRF_rcpt. DR InterPro; IPR036445; GPCR_2_extracell_dom_sf. DR InterPro; IPR001879; GPCR_2_extracellular_dom. DR InterPro; IPR000832; GPCR_2_secretin-like. DR InterPro; IPR017983; GPCR_2_secretin-like_CS. DR Pfam; PF00002; 7tm_2; 1. DR Pfam; PF02793; HRM; 1. DR PRINTS; PR01279; CRFRECEPTOR. DR PRINTS; PR01280; CRFRECEPTOR1. DR PRINTS; PR00249; GPCRSECRETIN. DR SMART; SM00008; HormR; 1. DR SUPFAM; SSF111418; SSF111418; 1. DR PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1. DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1. DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW G-protein coupled receptor {ECO:0000256|SAAS:SAAS00978998}; KW Membrane {ECO:0000256|SAAS:SAAS00501090, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A0A0MQZ1}; KW Receptor {ECO:0000256|SAAS:SAAS00978998}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transducer {ECO:0000256|SAAS:SAAS00978998}; KW Transmembrane {ECO:0000256|SAAS:SAAS00501090, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00501090, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 430 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015032299. FT TRANSMEM 121 142 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 182 201 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 232 251 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 258 277 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 299 320 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 341 360 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 372 389 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 29 106 G_PROTEIN_RECEP_F2_3. FT {ECO:0000259|PROSITE:PS50227}. FT DOMAIN 119 384 G_PROTEIN_RECEP_F2_4. FT {ECO:0000259|PROSITE:PS50261}. SQ SEQUENCE 430 AA; 49078 MW; 33561DA5B569A3EE CRC64; MGGHPQLRLV KALLLLGLNP VSASLQDQHC ESLSLASNIS GLQCNASVDL IGTCWPRSPA GQLVVRPCPA FFYGVRYNTT NNGYRECLAN GSWAARVNYS ECQEILNEEK KSKVHYHVAV IINYLGHCIS LVALLVAFVL FLRLRPGCTH WGDQADGALE VGAPWSGAPF QVRRSIRCLR NIIHWNLISA FILRNATWFV VQLTMSPEVH QSNVGWCRLV TAAYNYFHVT NFFWMFGEGC YLHTAIVLTY STDRLRKWMF ICIGWGVPFP IIVAWAIGKL YYDNEKCWFG KRPGVYTDYI YQGPMILVLL INFIFLFNIV RILMTKLRAS TTSETIQYRK AVKATLVLLP LLGITYMLFF VNPGEDEVSR VVFIYFNSFL ESFQVRSAIR KRWHRWQDKH SIRARVARAM SIPTSPTRVS FHSIKQSTAV //