ID A0A0A0MQW6_HUMAN Unreviewed; 1103 AA. AC A0A0A0MQW6; DT 07-JAN-2015, integrated into UniProtKB/TrEMBL. DT 07-JAN-2015, sequence version 1. DT 16-JAN-2019, entry version 41. DE SubName: Full=A disintegrin and metalloproteinase with thrombospondin motifs 10 {ECO:0000313|Ensembl:ENSP00000270328}; GN Name=ADAMTS10 {ECO:0000313|Ensembl:ENSP00000270328}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000270328, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000270328, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000270328} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2014) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC130469; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC243312; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_112219.3; NM_030957.3. DR RefSeq; XP_016882827.1; XM_017027338.1. DR UniGene; Hs.657508; -. DR SMR; A0A0A0MQW6; -. DR PeptideAtlas; A0A0A0MQW6; -. DR PRIDE; A0A0A0MQW6; -. DR Ensembl; ENST00000270328; ENSP00000270328; ENSG00000142303. DR Ensembl; ENST00000597188; ENSP00000471851; ENSG00000142303. DR GeneID; 81794; -. DR KEGG; hsa:81794; -. DR UCSC; uc002mkj.3; human. DR CTD; 81794; -. DR EuPathDB; HostDB:ENSG00000142303.13; -. DR HGNC; HGNC:13201; ADAMTS10. DR OpenTargets; ENSG00000142303; -. DR eggNOG; KOG3538; Eukaryota. DR eggNOG; ENOG410XPKZ; LUCA. DR GeneTree; ENSGT00940000158404; -. DR KO; K08625; -. DR OMA; YHGRRDI; -. DR OrthoDB; 125522at2759; -. DR ChiTaRS; ADAMTS10; human. DR GenomeRNAi; 81794; -. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; ENSG00000142303; Expressed in 204 organ(s), highest expression level in islet of Langerhans. DR ExpressionAtlas; A0A0A0MQW6; baseline and differential. DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro. DR Gene3D; 2.20.100.10; -; 5. DR Gene3D; 3.40.390.10; -; 1. DR InterPro; IPR010294; ADAM_spacer1. DR InterPro; IPR013273; ADAMTS/ADAMTS-like. DR InterPro; IPR024079; MetalloPept_cat_dom_sf. DR InterPro; IPR001590; Peptidase_M12B. DR InterPro; IPR002870; Peptidase_M12B_N. DR InterPro; IPR010909; PLAC. DR InterPro; IPR000884; TSP1_rpt. DR InterPro; IPR036383; TSP1_rpt_sf. DR Pfam; PF05986; ADAM_spacer1; 1. DR Pfam; PF01562; Pep_M12B_propep; 1. DR Pfam; PF08686; PLAC; 1. DR Pfam; PF01421; Reprolysin; 1. DR Pfam; PF00090; TSP_1; 5. DR PRINTS; PR01857; ADAMTSFAMILY. DR SMART; SM00209; TSP1; 5. DR SUPFAM; SSF82895; SSF82895; 5. DR PROSITE; PS50215; ADAM_MEPRO; 1. DR PROSITE; PS50900; PLAC; 1. DR PROSITE; PS50092; TSP1; 5. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00517240}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 1103 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014015964. FT DOMAIN 239 457 Peptidase M12B. FT {ECO:0000259|PROSITE:PS50215}. FT DOMAIN 1065 1103 PLAC. {ECO:0000259|PROSITE:PS50900}. SQ SEQUENCE 1103 AA; 120860 MW; 66B89F08A74D5990 CRC64; MAPACQILRW ALALGLGLMF EVTHAFRSQD EFLSSLESYE IAFPTRVDHN GALLAFSPPP PRRQRRGTGA TAESRLFYKV ASPSTHFLLN LTRSSRLLAG HVSVEYWTRE GLAWQRAARP HCLYAGHLQG QASSSHVAIS TCGGLHGLIV ADEEEYLIEP LHGGPKGSRS PEESGPHVVY KRSSLRHPHL DTACGVRDEK PWKGRPWWLR TLKPPPARPL GNETERGQPG LKRSVSRERY VETLVVADKM MVAYHGRRDV EQYVLAIMNI VAKLFQDSSL GSTVNILVTR LILLTEDQPT LEITHHAGKS LDSFCKWQKS IVNHSGHGNA IPENGVANHD TAVLITRYDI CIYKNKPCGT LGLAPVGGMC ERERSCSVNE DIGLATAFTI AHEIGHTFGM NHDGVGNSCG ARGQDPAKLM AAHITMKTNP FVWSSCSRDY ITSFLDSGLG LCLNNRPPRQ DFVYPTVAPG QAYDADEQCR FQHGVKSRQC KYGEVCSELW CLSKSNRCIT NSIPAAEGTL CQTHTIDKGW CYKRVCVPFG SRPEGVDGAW GPWTPWGDCS RTCGGGVSSS SRHCDSPRPT IGGKYCLGER RRHRSCNTDD CPPGSQDFRE VQCSEFDSIP FRGKFYKWKT YRGGGVKACS LTCLAEGFNF YTERAAAVVD GTPCRPDTVD ICVSGECKHV GCDRVLGSDL REDKCRVCGG DGSACETIEG VFSPASPGAG YEDVVWIPKG SVHIFIQDLN LSLSHLALKG DQESLLLEGL PGTPQPHRLP LAGTTFQLRQ GPDQVQSLEA LGPINASLIV MVLARTELPA LRYRFNAPIA RDSLPPYSWH YAPWTKCSAQ CAGGSQVQAV ECRNQLDSSA VAPHYCSAHS KLPKRQRACN TEPCPPDWVV GNWSLCSRSC DAGVRSRSVV CQRRVSAAEE KALDDSACPQ PRPPVLEACH GPTCPPEWAA LDWSECTPSC GPGLRHRVVL CKSADHRATL PPAHCSPAAK PPATMRCNLR RCPPARWVAG EWGECSAQCG VGQRQRSVRC TSHTGQASHE CTEALRPPTT QQCEAKCDSP TPGDGPEECK DVNKVAYCPL VLKFQFCSRA YFRQMCCKTC HGH //