ID   A0A0A0MQV3_HUMAN        Unreviewed;       633 AA.
AC   A0A0A0MQV3;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   16-JAN-2019, entry version 34.
DE   SubName: Full=Kin of IRRE-like protein 2 {ECO:0000313|Ensembl:ENSP00000262625};
GN   Name=KIRREL2 {ECO:0000313|Ensembl:ENSP00000262625};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000262625, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000262625, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000262625}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
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DR   EMBL; AC002133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AD000864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_115499.5; NM_032123.6.
DR   UniGene; Hs.145729; -.
DR   ProteinModelPortal; A0A0A0MQV3; -.
DR   PRIDE; A0A0A0MQV3; -.
DR   Ensembl; ENST00000262625; ENSP00000262625; ENSG00000126259.
DR   GeneID; 84063; -.
DR   UCSC; uc002obz.5; human.
DR   CTD; 84063; -.
DR   EuPathDB; HostDB:ENSG00000126259.19; -.
DR   HGNC; HGNC:18816; KIRREL2.
DR   OpenTargets; ENSG00000126259; -.
DR   eggNOG; KOG3510; Eukaryota.
DR   eggNOG; ENOG410XPX0; LUCA.
DR   GeneTree; ENSGT00940000160603; -.
DR   OrthoDB; 269917at2759; -.
DR   ChiTaRS; KIRREL2; human.
DR   GenomeRNAi; 84063; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000126259; Expressed in 66 organ(s), highest expression level in body of pancreas.
DR   ExpressionAtlas; A0A0A0MQV3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 5.
DR   InterPro; IPR013162; CD80_C2-set.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   Pfam; PF08205; C2-set_2; 1.
DR   Pfam; PF07679; I-set; 1.
DR   SMART; SM00409; IG; 5.
DR   SMART; SM00408; IGc2; 3.
DR   SUPFAM; SSF48726; SSF48726; 5.
DR   PROSITE; PS50835; IG_LIKE; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00504776};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS01086444};
KW   Membrane {ECO:0000256|SAAS:SAAS00555568, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00289622};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00555568,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00555568,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    633       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001967056.
FT   TRANSMEM    511    534       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       24    118       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      123    222       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      227    307       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      312    394       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      398    501       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   633 AA;  67128 MW;  1AC252C19237A752 CRC64;
     MLRMRVPALL VLLFCFRGRA GPSPHFLQQP EDLVVLLGEE ARLPCALGAY WGLVQWTKSG
     LALGGQRDLP GWSRYWISGN AANGQHDLHI RPVELEDEAS YECQATQAGL RSRPAQLHVL
     VPPEAPQVLG GPSVSLVAGV PANLTCRSRG DARPTPELLW FRDGVLLDGA TFHQTLLKEG
     TPGSVESTLT LTPFSHDDGA TFVCRARSQA LPTGRDTAIT LSLQYPPEVT LSASPHTVQE
     GEKVIFLCQA TAQPPVTGYR WAKGGSPVLG ARGPRLEVVA DASFLTEPVS CEVSNAVGSA
     NRSTALDVLF GPILQAKPEP VSVDVGEDAS FSCAWRGNPL PRVTWTRRGG AQVLGSGATL
     RLPSVGPEDA GDYVCRAEAG LSGLRGGAAE ARLTVNAPPV VTALHSAPAF LRGPARLQCL
     VFASPAPDAV VWSWDEGFLE AGSQGRFLVE TFPAPESRGG LGPGLISVLH ISGTQESDFS
     RSFNCSARNR LGEGGAQASL GRRDLLPTVR IVAGVAAATT TLLMVITGVA LCCWRHSKAS
     ASFSEQKNLM RIPGSSDGSS SRGPEEEETG SREDRGPIVH TDHSDLVLEE EGTLETKDPT
     NGYYKVRGVS PPASPDSRVT SFQWKSPGIS NLP
//