ID   A0A0A0MQU8_HUMAN        Unreviewed;       190 AA.
AC   A0A0A0MQU8;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   16-JAN-2019, entry version 30.
DE   SubName: Full=Interferon alpha-6 {ECO:0000313|Ensembl:ENSP00000259555};
GN   Name=IFNA6 {ECO:0000313|Ensembl:ENSP00000259555};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000259555, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000259555, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000259555}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00135286}.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family.
CC       {ECO:0000256|RuleBase:RU000436, ECO:0000256|SAAS:SAAS00562792}.
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DR   EMBL; AL353732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A0A0MQU8; -.
DR   SMR; A0A0A0MQU8; -.
DR   jPOST; A0A0A0MQU8; -.
DR   Ensembl; ENST00000259555; ENSP00000259555; ENSG00000120235.
DR   UCSC; uc064sji.1; human.
DR   EuPathDB; HostDB:ENSG00000120235.4; -.
DR   HGNC; HGNC:5427; IFNA6.
DR   OpenTargets; ENSG00000120235; -.
DR   eggNOG; ENOG410J735; Eukaryota.
DR   eggNOG; ENOG410ZH91; LUCA.
DR   GeneTree; ENSGT00940000153163; -.
DR   OMA; HRRTMML; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   Bgee; ENSG00000120235; Expressed in 18 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; A0A0A0MQU8; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   CDD; cd00095; IFab; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691; PTHR11691; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   1: Evidence at protein level;
KW   Antiviral defense {ECO:0000256|RuleBase:RU000436,
KW   ECO:0000256|SAAS:SAAS00065439};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Cytokine {ECO:0000256|RuleBase:RU000436,
KW   ECO:0000256|SAAS:SAAS00449409};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00135285};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A0A0MQU8,
KW   ECO:0000213|PeptideAtlas:A0A0A0MQU8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00135283};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    190       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001974395.
SQ   SEQUENCE   190 AA;  22242 MW;  784A8A5080C9C20B CRC64;
     TMALPFALLM ALVVLSCKSS CSLDCDLPQT HSLGHRRTMM LLAQMRRISL FSCLKDRHDF
     RFPQEEFDGN QFQKAEAISV LHEVIQQTFN LFSTKDSSVA WDERLLDKLY TELYQQLNDL
     EACVMQEVWV GGTPLMNEDS ILAVRKYFQR ITLYLTEKKY SPCAWEVVRA EIMRSFSSSR
     NLQERLRRKE
//