ID   A0A0A0MQS6_HUMAN        Unreviewed;      3359 AA.
AC   A0A0A0MQS6;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 2.
DT   16-JAN-2019, entry version 33.
DE   SubName: Full=Cadherin-23 {ECO:0000313|Ensembl:ENSP00000224721};
GN   Name=CDH23 {ECO:0000313|Ensembl:ENSP00000224721};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000224721, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000224721, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000224721}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2014) to UniProtKB.
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DR   EMBL; AC012469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL359183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL731541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL772287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; A0A0A0MQS6; -.
DR   EPD; A0A0A0MQS6; -.
DR   jPOST; A0A0A0MQS6; -.
DR   PeptideAtlas; A0A0A0MQS6; -.
DR   PRIDE; A0A0A0MQS6; -.
DR   Ensembl; ENST00000224721; ENSP00000224721; ENSG00000107736.
DR   UCSC; uc057twh.1; human.
DR   EuPathDB; HostDB:ENSG00000107736.19; -.
DR   HGNC; HGNC:13733; CDH23.
DR   OpenTargets; ENSG00000107736; -.
DR   eggNOG; KOG1219; Eukaryota.
DR   eggNOG; ENOG410XPEI; LUCA.
DR   ChiTaRS; CDH23; human.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000107736; Expressed in 110 organ(s), highest expression level in right hemisphere of cerebellum.
DR   ExpressionAtlas; A0A0A0MQS6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0032420; C:stereocilium; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   GO; GO:0060122; P:inner ear receptor cell stereocilium organization; IEA:InterPro.
DR   GO; GO:0007626; P:locomotory behavior; IEA:InterPro.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR033030; CDH23.
DR   PANTHER; PTHR43956:SF3; PTHR43956:SF3; 1.
DR   Pfam; PF00028; Cadherin; 24.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 26.
DR   SUPFAM; SSF49313; SSF49313; 27.
DR   PROSITE; PS00232; CADHERIN_1; 10.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00020193};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00616217, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0A0MQS6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24   3359       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5006547363.
FT   TRANSMEM   3072   3095       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       55    130       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      159    239       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      263    351       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      376    463       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      487    564       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      588    674       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      698    781       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      805    893       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      917    998       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1022   1105       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1129   1211       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1236   1316       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1340   1421       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1446   1530       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1555   1637       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1662   1747       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1771   1854       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1878   1962       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1990   2072       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     2096   2177       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     2201   2296       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     2323   2405       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     2429   2512       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     2536   2614       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     2640   2725       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     2756   2849       CA. {ECO:0000259|SMART:SM00112}.
SQ   SEQUENCE   3359 AA;  369879 MW;  997AFCC5427FC61D CRC64;
     MGRHVATSCH VAWLLVLISG CWGQVNRLPF FTNHFFDTYL LISEDTPVGS SVTQLLAQDM
     DNDPLVFGVS GEEASRFFAV EPDTGVVWLR QPLDRETKSE FTVEFSVSDH QGVITRKVNI
     QVGDVNDNAP TFHNQPYSVR IPEVGATGNT PVGTPIFIVN ATDPDLGAGG SVLYSFQPPS
     QFFAIDSARG IVTVIRELDY ETTQAYQLTV NATDQDKTRP LSTLANLAII ITDVQDMDPI
     FINLPYSTNI YEHSPPGTTV RIITAIDQDK GRPRGIGYTI VSGNTNSIFA LDYISGVLTL
     NGLLDRENPL YSHGFILTVK GTELNDDRTP SDATVTTTFN ILVIDINDNA PEFNSSEYSV
     AITELAQVGF ALPLFIQVVD KDENLGLNSM FEVYLVGNNS HHFIISPTSV QGKADIRIRV
     AIPLDYETVD RYDFDLFANE SVPDHVGYAK VKITLINEND NRPIFSQPLY NISLYENVTV
     GTSVLTVLAT DNDAGTFGEV SYFFSDDPDR FSLDKDTGLI MLIARLDYEL IQRFTLTIIA
     RDGGGEETTG RVRINVLDVN DNVPTFQKDA YVGALRENEP SVTQLVRLRA TDEDSPPNNQ
     ITYSIVSASA FGSYFDISLY EGYGVISVSR PLDYEQISNG LIYLTVMAMD AGNPPLNSTV
     PVTIEVFDEN DNPPTFSKPA YFVSVVENIM AGATVLFLNA TDLDRSREYG QESIIYSLEG
     STQFRINARS GEITTTSLLD RETKSEYILI VRAVDGGVGH NQKTGIATVN ITLLDINDNH
     PTWKDAPYYI NLVEMTPPDS DVTTVVAVDP DLGENGTLVY SIQPPNKFYS LNSTTGKIRT
     THAMLDRENP DPHEAELMRK IVVSVTDCGR PPLKATSSAT VFVNLLDLND NDPTFQNLPF
     VAEVLEGIPA GVSIYQVVAI DLDEGLNGLV SYRMPVGMPR MDFLINSSSG VVVTTTELDR
     ERIAEYQLRV VASDAGTPTK SSTSTLTIHV LDVNDETPTF FPAVYNVSVS EDVPREFRVV
     WLNCTDNDVG LNAELSYFIT GGNVDGKFSV GYRDAVVRTV VGLDRETTAA YMLILEAIDN
     GPVGKRHTGT ATVFVTVLDV NDNRPIFLQS SYEASVPEDI PEGHSILQLK ATDADEGEFG
     RVWYRILHGN HGNNFRIHVS NGLLMRGPRP LDRERNSSHV LIVEAYNHDL GPMRSSVRVI
     VYVEDINDEA PVFTQQQYSR LGLRETAGIG TSVIVVQATD RDSGDGGLVN YRILSGAEGK
     FEIDESTGLI ITVNYLDYET KTSYMMNVSA TDQAPPFNQG FCSVYITLLN ELDEAVQFSN
     ASYEAAILEN LALGTEIVRV QAYSIDNLNQ ITYRFNAYTS TQAKALFKID AITGVITVQG
     LVDREKGDFY TLTVVADDGG PKVDSTVKVY ITVLDENDNS PRFDFTSDSA VSIPEDCPVG
     QRVATVKAWD PDAGSNGQVV FSLASGNIAG AFEIVTTNDS IGEVFVARPL DREELDHYIL
     QVVASDRGTP PRKKDHILQV TILDINDNPP VIESPFGYNV SVNENVGGGT AVVQVRATDR
     DIGINSVLSY YITEGNKDMA FRMDRISGEI ATRPAPPDRE RQSFYHLVAT VEDEGTPTLS
     ATTHVYVTIV DENDNAPMFQ QPHYEVLLDE GPDTLNTSLI TIQALDLDEG PNGTVTYAIV
     AGNIVNTFRI DRHMGVITAA KELDYEISHG RYTLIVTATD QCPILSHRLT STTTVLVNVN
     DINDNVPTFP RDYEGPFEVT EGQPGPRVWT FLAHDRDSGP NGQVEYSIMD GDPLGEFVIS
     PVEGVLRVRK DVELDRETIA FYNLTICARD RGMPPLSSTM LVGIRVLDIN DNDPVLLNLP
     MNITISENSP VSSFVAHVLA SDADSGCNAR LTFNITAGNR ERAFFINATT GIVTVNRPLD
     RERIPEYKLT ISVKDNPENP RIARRDYDLL LIFLSDENDN HPLFTKSTYQ AEVMENSPAG
     TPLTVLNGPI LALDADQDIY AVVTYQLLGA QSGLFDINSS TGVVTVRSGV IIDREAFSPP
     ILELLLLAED IGLLNSTAHL LITILDDNDN RPTFSPATLT VHLLENCPPG FSVLQVTATD
     EDSGLNGELV YRIEAGAQDR FLIHLVTGVI RVGNATIDRE EQESYRLTVV ATDRGTVPLS
     GTAIVTILID DINDSRPEFL NPIQTVSVLE SAEPGTVIAN ITAIDHDLNP KLEYHIVGIV
     AKDDTDRLVP NQEDAFAVNI NTGSVMVKSP MNRELVATYE VTLSVIDNAS DLPERSVSVP
     NAKLTVNVLD VNDNTPQFKP FGITYYMERI LEGATPGTTL IAVAAVDPDK GLNGLVTYTL
     LDLVPPGYVQ LEDSSAGKVI ANRTVDYEEV HWLNFTVRAS DNGSPPRAAE IPVYLEIVDI
     NDNNPIFDQP SYQEAVFEDV PVGTIILTVT ATDADSGNFA LIEYSLGDGE SKFAINPTTG
     DIYVLSSLDR EKKDHYILTA LAKDNPGDVA SNRRENSVQV VIQVLDVNDC RPQFSKPQFS
     TSVYENEPAG TSVITMMATD QDEGPNGELT YSLEGPGVEA FHVDMDSGLV TTQRPLQSYE
     KFSLTVVATD GGEPPLWGTT MLLVEVIDVN DNRPVFVRPP NGTILHIREE IPLRSNVYEV
     YATDKDEGLN GAVRYSFLKT AGNRDWEFFI IDPISGLIQT AQRLDRESQA VYSLILVASD
     LGQPVPYETM QPLQVALEDI DDNEPLFVRP PKGSPQYQLL TVPEHSPRGT LVGNVTGAVD
     ADEGPNAIVY YFIAAGNEEK NFHLQPDGCL LVLRDLDRER EAIFSFIVKA SSNRSWTPPR
     GPSPTLDLVA DLTLQEVRVV LEDINDQPPR FTKAEYTAGV ATDAKVGSEL IQVLALDADI
     GNNSLVFYSI LAIHYFRALA NDSEDVGQVF TMGSMDGILR TFDLFMAYSP GYFVVDIVAR
     DLAGHNDTAI IGIYILRDDQ RVKIVINEIP DRVRGFEEEF IHLLSNITGA IVNTDNVQFH
     VDKKGRVNFA QTELLIHVVN RDTNRILDVD RVIQMIDENK EQLRNLFRNY NVLDVQPAIS
     VRLPDDMSAL QMAIIVLAIL LFLAAMLFVL MNWYYRTVHK RKLKAIVAGS AGNRGFIDIM
     DMPNTNKYSF DGANPVWLDP FCRNLELAAQ AEHEDDLPEN LSEIADLWNS PTRTHGTFGR
     EPAAVKPDDD RYLRAAIQEY DNIAKLGQII REGPIKGSLL KVVLEDYLRL KKLFAQRMVQ
     KASSCHSSIS ELIQTELDEE PGDHSPGQGS LRFRHKPPVE LKGPDGIHVV HGSTGTLLAT
     DLNSLPEEDQ KGLGRSLETL TAAEATAFER NARTESAKST PLHKLRDVIM ETPLEITEL
//