ID   D131B_HUMAN             Reviewed;          70 AA.
AC   A0A096LNP1;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   26-NOV-2014, sequence version 1.
DT   16-JAN-2019, entry version 30.
DE   RecName: Full=Beta-defensin 131B {ECO:0000305};
DE   AltName: Full=Defensin, beta 131 {ECO:0000312|HGNC:HGNC:38058};
DE   Flags: Precursor;
GN   Name=DEFB131B {ECO:0000312|HGNC:HGNC:38058};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA   Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA   FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA   Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA   Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA   Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AP002495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS76450.1; -.
DR   RefSeq; NP_001229782.1; NM_001242853.1.
DR   UniGene; Hs.740246; -.
DR   ProteinModelPortal; A0A096LNP1; -.
DR   BioMuta; DEFB131B; -.
DR   Ensembl; ENST00000530210; ENSP00000485141; ENSG00000225805.
DR   GeneID; 100129216; -.
DR   KEGG; hsa:100129216; -.
DR   UCSC; uc021qmu.1; human.
DR   CTD; 100129216; -.
DR   EuPathDB; HostDB:ENSG00000225805.4; -.
DR   GeneCards; DEFB131B; -.
DR   HGNC; HGNC:38058; DEFB131B.
DR   neXtProt; NX_A0A096LNP1; -.
DR   GeneTree; ENSGT00390000001538; -.
DR   OMA; EYAVRYC; -.
DR   OrthoDB; 1638187at2759; -.
DR   GenomeRNAi; 100129216; -.
DR   PRO; PR:A0A096LNP1; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000225805; Expressed in 67 organ(s), highest expression level in testis.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   PANTHER; PTHR15001; PTHR15001; 1.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Complete proteome; Defensin;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     22       {ECO:0000255}.
FT   PEPTIDE      23     70       Beta-defensin 131B.
FT                                /FTId=PRO_0000441044.
FT   DISULFID     29     56       {ECO:0000250}.
FT   DISULFID     36     50       {ECO:0000250}.
FT   DISULFID     40     57       {ECO:0000250}.
SQ   SEQUENCE   70 AA;  8156 MW;  5044FA93A488E499 CRC64;
     MRVLFFVFGV LSLMSTVPPT RSFTSNDECP SEYYHCRLKC NADEHAIRYC ADFSICCKLK
     IIQIDGQKKW
//