ID   A0A087X2A4_HUMAN        Unreviewed;       484 AA.
AC   A0A087X2A4;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 30.
DE   SubName: Full=Mucin-1 {ECO:0000313|Ensembl:ENSP00000484824};
GN   Name=MUC1 {ECO:0000313|Ensembl:ENSP00000484824};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000484824, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000484824, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [3] {ECO:0000313|Ensembl:ENSP00000484824}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC234582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001191215.1; NM_001204286.1.
DR   UniGene; Hs.89603; -.
DR   ProteinModelPortal; A0A087X2A4; -.
DR   SMR; A0A087X2A4; -.
DR   jPOST; A0A087X2A4; -.
DR   PeptideAtlas; A0A087X2A4; -.
DR   PRIDE; A0A087X2A4; -.
DR   Ensembl; ENST00000612778; ENSP00000484824; ENSG00000185499.
DR   GeneID; 4582; -.
DR   KEGG; hsa:4582; -.
DR   UCSC; uc057lmt.1; human.
DR   CTD; 4582; -.
DR   EuPathDB; HostDB:ENSG00000185499.16; -.
DR   HGNC; HGNC:7508; MUC1.
DR   OpenTargets; ENSG00000185499; -.
DR   eggNOG; ENOG410IX6R; Eukaryota.
DR   eggNOG; ENOG410ZQ7Z; LUCA.
DR   GeneTree; ENSGT00710000106874; -.
DR   KO; K06568; -.
DR   OrthoDB; 945460at2759; -.
DR   ChiTaRS; MUC1; human.
DR   GenomeRNAi; 4582; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000185499; Expressed in 199 organ(s), highest expression level in body of stomach.
DR   ExpressionAtlas; A0A087X2A4; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.960; -; 1.
DR   InterPro; IPR000082; SEA_dom.
DR   InterPro; IPR036364; SEA_dom_sf.
DR   Pfam; PF01390; SEA; 1.
DR   SMART; SM00200; SEA; 1.
DR   SUPFAM; SSF82671; SSF82671; 1.
DR   PROSITE; PS50024; SEA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A0A087X2A4,
KW   ECO:0000213|MaxQB:A0A087X2A4, ECO:0000213|PeptideAtlas:A0A087X2A4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    484       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832227.
FT   TRANSMEM    388    413       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      268    377       SEA. {ECO:0000259|PROSITE:PS50024}.
SQ   SEQUENCE   484 AA;  50063 MW;  FE0B2FC6FB205D29 CRC64;
     MTPGTQSPFF LLLLLTVLTA TTAPKPATVV TGSGHASSTP GGEKETSATQ RSSVPSSTEK
     NAVSMTSSVL SSHSPGSGSS TTQGQDVTLA PATEPASGSA ATWGQDVTSV PVTRPALGST
     TPPAHDVTSA PDNKPAPGST APPAHGVTSA PDTRPAPGST APPAHGVTSA PDNRPALGST
     APPVHNVTSA SGSASGSAST LVHNGTSARA TTTPASKSTP FSIPSHHSDT PTTLASHSTK
     TDASSTHHST VPPLTSSNHS TSPQLSTGVS FFFLSFHISN LQFNSSLEDP STDYYQELQR
     DISEMFLQIY KQGGFLGLSN IKFRPGSVVV QLTLAFREGT INVHDVETQF NQYKTEAASR
     YNLTISDVSV SDVPFPFSAQ SGAGVPGWGI ALLVLVCVLV ALAIVYLIAL AVCQCRRKNY
     GQLDIFPARD TYHPMSEYPT YHTHGRYVPP SSTDRSPYEK VSAGNGGSSL SYTNPAVAAT
     SANL
//