ID   A0A087X296_HUMAN        Unreviewed;       551 AA.
AC   A0A087X296;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   13-FEB-2019, entry version 35.
DE   SubName: Full=Prostaglandin G/H synthase 1 {ECO:0000313|Ensembl:ENSP00000484800};
GN   Name=PTGS1 {ECO:0000313|Ensembl:ENSP00000484800};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000484800, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000484800, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000484800}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
RN   [4] {ECO:0000313|Ensembl:ENSP00000483540}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AL162424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL359636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001258093.1; NM_001271164.1.
DR   UniGene; Hs.201978; -.
DR   ProteinModelPortal; A0A087X296; -.
DR   SMR; A0A087X296; -.
DR   EPD; A0A087X296; -.
DR   jPOST; A0A087X296; -.
DR   PeptideAtlas; A0A087X296; -.
DR   PRIDE; A0A087X296; -.
DR   Ensembl; ENST00000614910; ENSP00000484800; ENSG00000095303.
DR   Ensembl; ENST00000619306; ENSP00000483540; ENSG00000095303.
DR   GeneID; 5742; -.
DR   UCSC; uc031tey.2; human.
DR   CTD; 5742; -.
DR   EuPathDB; HostDB:ENSG00000095303.14; -.
DR   HGNC; HGNC:9604; PTGS1.
DR   OpenTargets; ENSG00000095303; -.
DR   GeneTree; ENSGT00390000010743; -.
DR   OrthoDB; 324380at2759; -.
DR   ChiTaRS; PTGS1; human.
DR   GenomeRNAi; 5742; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   Bgee; ENSG00000095303; Expressed in 210 organ(s), highest expression level in fundus of stomach.
DR   ExpressionAtlas; A0A087X296; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0001750; C:photoreceptor outer segment; IEA:Ensembl.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR   GO; GO:0004666; F:prostaglandin-endoperoxide synthase activity; IEA:InterPro.
DR   GO; GO:0019371; P:cyclooxygenase pathway; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   Gene3D; 1.10.640.10; -; 1.
DR   InterPro; IPR029580; COX-1.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR019791; Haem_peroxidase_animal.
DR   InterPro; IPR010255; Haem_peroxidase_sf.
DR   InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR   PANTHER; PTHR11903:SF6; PTHR11903:SF6; 2.
DR   Pfam; PF03098; An_peroxidase; 1.
DR   Pfam; PF00008; EGF; 1.
DR   PRINTS; PR00457; ANPEROXIDASE.
DR   SUPFAM; SSF48113; SSF48113; 1.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS50292; PEROXIDASE_3; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Proteomics identification {ECO:0000213|EPD:A0A087X296,
KW   ECO:0000213|MaxQB:A0A087X296, ECO:0000213|PeptideAtlas:A0A087X296};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    551       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832223.
FT   DOMAIN       31     69       EGF-like. {ECO:0000259|PROSITE:PS50026}.
SQ   SEQUENCE   551 AA;  63286 MW;  8FB64B70ECFB4662 CRC64;
     MSRSLLLWFL LFLLLLPPLP VLLADPGAPT PVNPCCYYPC QHQGICVRFG LDRYQCDCTR
     TGYSGPNCTI PGLWTWLRNS LRPSPSFTHF LLTHGRWFWE FVNATFIREM LMRLVLTGKK
     QLPDAQLLAR RFLLRRKFIP DPQGTNLMFA FFAQHFTHQF FKTSGKMGPG FTKALGHGVD
     LGHIYGDNLE RQYQLRLFKD GKLKYQVLDG EMYPPSVEEA PVLMHYPRGI PPQSQMAVGQ
     EVFGLLPGLM LYATLWLREH NRVCDLLKAE HPTWGDEQLF QTTRLILIGE TIKIVIEEYV
     QQLSGYFLQL KFDPELLFGV QFQYRNRIAM EFNHLYHWHP LMPDSFKVGS QEYSYEQFLF
     NTSMLVDYGV EALVDAFSRQ IAGRIGGGRN MDHHILHVAV DVIRESREMR LQPFNEYRKR
     FGMKPYTSFQ ELVGEKEMAA ELEELYGDID ALEFYPGLLL EKCHPNSIFG ESMIEIGAPF
     SLKGLLGNPI CSPEYWKPST FGGEVGFNIV KTATLKKLVC LNTKTCPYVS FRVPDASQDD
     GPAVERPSTE L
//