ID   A0A087X250_HUMAN        Unreviewed;      1964 AA.
AC   A0A087X250;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 38.
DE   SubName: Full=Protocadherin-15 {ECO:0000313|Ensembl:ENSP00000484703};
GN   Name=PCDH15 {ECO:0000313|Ensembl:ENSP00000484703};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000484703, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000484703, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000484703}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC013737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC016817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC024073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC027671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL353784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL360214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL365496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL391356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087X250; -.
DR   Ensembl; ENST00000617051; ENSP00000484703; ENSG00000150275.
DR   UCSC; uc057til.1; human.
DR   EuPathDB; HostDB:ENSG00000150275.17; -.
DR   HGNC; HGNC:14674; PCDH15.
DR   OpenTargets; ENSG00000150275; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   eggNOG; ENOG410XQHI; LUCA.
DR   GeneTree; ENSGT00940000156675; -.
DR   ChiTaRS; PCDH15; human.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000150275; Expressed in 67 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; A0A087X250; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0032420; C:stereocilium; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   GO; GO:0048839; P:inner ear development; IEA:InterPro.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR030718; Protocadherin-15.
DR   PANTHER; PTHR24028:SF11; PTHR24028:SF11; 5.
DR   Pfam; PF00028; Cadherin; 8.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 11.
DR   SUPFAM; SSF49313; SSF49313; 10.
DR   PROSITE; PS00232; CADHERIN_1; 3.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00020193};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00616217, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A087X250};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27   1964       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832204.
FT   TRANSMEM   1380   1402       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       69    150       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      179    268       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      309    398       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      431    512       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      536    618       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      643    720       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      744    822       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      846    929       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      953   1039       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1060   1147       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN     1171   1255       CA. {ECO:0000259|SMART:SM00112}.
SQ   SEQUENCE   1964 AA;  217135 MW;  990B6C8B6FB0F312 CRC64;
     MFRQFYLWTC LASGIILGSL FEICLGQYDD DWQYEDCKLA RGGPPATIVA IDEESRNGTI
     LVDNMLIKGT AGGPDPTIEL SLKDNVDYWV LMDPVKQMLF LNSTGRVLDR DPPMNIHSIV
     VQVQCINKKV GTIIYHEVRI VVRDRNDNSP TFKHESYYAT VNELTPVGTT IFTGFSGDNG
     ATDIDDGPNG QIEYVIQYNP DDPTSNDTFE IPLMLTGNIV LRKRLNYEDK TRYFVIIQAN
     DRAQNLNERR TTTTTLTVDV LDGDDLGPMF LPCVLVPNTR DCRPLTYQAA IPELRTPEEL
     NPIIVTPPIQ AIDQDRNIQP PSDRPGILYS ILVGTPEDYP RFFHMHPRTA ELSLLEPVNR
     DFHQKFDLVI KAEQDNGHPL PAFAGLHIEI LDENNQSPYF TMPSYQGYIL ESAPVGATIS
     DSLNLTSPLR IVALDKDIED TKDPELHLFL NDYTSVFTVT QTGITRYLTL LQPVDREEQQ
     TYTFSITAFD GVQESEPVIV NIQVMDANDN TPTFPEISYD VYVYTDMRPG DSVIQLTAVD
     ADEGSNGEIT YEILVGAQGD FIINKTTGLI TIAPGVEMIV GRTYALTVQA ADNAPPAERR
     NSICTVYIEV LPPNNQSPPR FPQLMYSLEI SEAMRVGAVL LNLQATDREG DSITYAIENG
     DPQRVFNLSE TTGILTLGKA LDRESTDRYI LIITASDGRP DGTSTATVNI VVTDVNDNAP
     VFDPYLPRNL SVVEEEANAF VGQVKATDPD AGINGQVHYS LGNFNNLFRI TSNGSIYTAV
     KLNREVRDYY ELVVVATDGA VHPRHSTLTL AIKVLDIDDN SPVFTNSTYT VLVEENLPAG
     TTILQIEAKD VDLGANVSYR IRSPEVKHFF ALHPFTGELS LLRSLDYEAF PDQEASITFL
     VEAFDIYGTM PPGIATVTVI VKDMNDYPPV FSKRIYKGMV APDAVKGTPI TTVYAEDADP
     PGLPASRVRY RVDDVQFPYP ASIFEVEEDS GRVITRVNLN EEPTTIFKLV VVAFDDGEPV
     MSSSATVKIL VLHPGEIPRF TQEEYRPPPV SELATKGTMV GVISAAAINQ SIVYSIVSGN
     EEDTFGINNI TGVIYVNGPL DYETRTSYVL RVQADSLEVV LANLRVPSKS NTAKVYIEIQ
     DENNHPPVFQ KKFYIGGVSE DARMFTSVLR VKATDKDTGN YSVMAYRLII PPIKEGKEGF
     VVETYTGLIK TAMLFHNMRR SYFKFQVIAT DDYGKGLSGK ADVLVSVVNQ LDMQVIVSNV
     PPTLVEKKIE DLTEILDRYV QEQIPGAKVV VESIGARRHG DAFSLEDYTK CDLTVYAIDP
     QTNRAIDRNE LFKFLDGKLL DINKDFQPYY GEGGRILEIR TPEAVTSIKK RGESLGYTEG
     ALLALAFIII LCCIPAILVV LVSYRQVFKG RQAECTKTAR IQAALPAAKP AVPAPAPVAA
     PPPPPPPPPG AHLYEELGDS SILSSLFLLY HFQQSRGNNS VSEDRKHQQV VMPFSSNTIE
     AHKSAHVDGS LKSNKLKSAR KFTFLSDEDD LSAHNPLYKE NISQVSTNSD ISQRTDFVDP
     FSPKIQAKSK SLRGPREKIQ RLWSQSVSLP RRLMRKVPNR PEIIDLQQWQ GTRQKAENEN
     TGICTNKRGS SNPLLTTEEA NLTEKEEIRQ GETLMIEGTE QLKSLSSDSS FCFPRPHFSF
     STLPTVSRTV ELKSEPNVIS SPAECSLELS PSRPCVLHSS LSRRETPICM LPIETERNIF
     ENFAHPPNIS PSACPLPPPP PISPPSPPPA PAPLAPPPDI SPFSLFCPPP SPPSIPLPLP
     PPTFFPLSVS TSGPPTPPLL PPFPTPLPPP PPSIPCPPPP SASFLSTECV CITGVKCTTN
     LMPAEKIKSS MTQLSTTTVC KTDPQREPKG ILRHVKNLAE LEKSVANMYS QIEKNYLRTN
     VSELQTMCPS EVTNMEITSE QNKGSLNNIV EGTEKQSHSQ STSL
//