ID   A0A087X238_HUMAN        Unreviewed;       149 AA.
AC   A0A087X238;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   12-SEP-2018, entry version 18.
DE   SubName: Full=Inactive heparanase-2 {ECO:0000313|Ensembl:ENSP00000484672};
GN   Name=HPSE2 {ECO:0000313|Ensembl:ENSP00000484672};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000484672, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000484672, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000484672}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AL139243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL356220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL356268; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL360075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL365210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL391260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL445251; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL590036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087X238; -.
DR   Ensembl; ENST00000614306; ENSP00000484672; ENSG00000172987.
DR   UCSC; uc057vhr.1; human.
DR   EuPathDB; HostDB:ENSG00000172987.12; -.
DR   HGNC; HGNC:18374; HPSE2.
DR   OpenTargets; ENSG00000172987; -.
DR   eggNOG; ENOG410IHNV; Eukaryota.
DR   eggNOG; ENOG410YDJW; LUCA.
DR   GeneTree; ENSGT00390000004874; -.
DR   ChiTaRS; HPSE2; human.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000172987; Expressed in 103 organ(s), highest expression level in lower esophagus.
DR   ExpressionAtlas; A0A087X238; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:InterPro.
DR   InterPro; IPR005199; Glyco_hydro_79.
DR   PANTHER; PTHR14363; PTHR14363; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A087X238};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     41       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        42    149       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832203.
SQ   SEQUENCE   149 AA;  16465 MW;  1AA5ED8B4C015F33 CRC64;
     MRVLCAFPEA MPSSNSRPPA CLAPGALYLA LLLHLSLSSQ AGDRRPLPVD RAAGLKEKTL
     ILLDVSTKNP VRTVNENFLS LQLDPSIIHD GWLDFLSSKR LVTLARGLSP AFLRFGGKRT
     DFLQFQNLRN PAKSRGGPGP DYYLKNYED
//