ID   A0A087X1V8_HUMAN        Unreviewed;       565 AA.
AC   A0A087X1V8; A0A087X290;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   16-JAN-2019, entry version 41.
DE   SubName: Full=Ovochymase-2 {ECO:0000313|Ensembl:ENSP00000484497};
GN   Name=OVCH2 {ECO:0000313|Ensembl:ENSP00000484497};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000484497, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000484497, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000484497}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|SAAS:SAAS00559343}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   EMBL; ABBA01028682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC104237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_937828.3; NM_198185.4.
DR   UniGene; Hs.532475; -.
DR   PRIDE; A0A087X1V8; -.
DR   Ensembl; ENST00000533663; ENSP00000484497; ENSG00000183378.
DR   Ensembl; ENST00000612000; ENSP00000484790; ENSG00000183378.
DR   GeneID; 341277; -.
DR   KEGG; hsa:341277; -.
DR   UCSC; uc031xev.2; human.
DR   CTD; 341277; -.
DR   EuPathDB; HostDB:ENSG00000183378.11; -.
DR   HGNC; HGNC:29970; OVCH2.
DR   OpenTargets; ENSG00000183378; -.
DR   GeneTree; ENSGT00940000157791; -.
DR   KO; K01362; -.
DR   OMA; EKGSYPW; -.
DR   OrthoDB; 1314811at2759; -.
DR   ChiTaRS; OVCH2; human.
DR   GenomeRNAi; 341277; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000183378; Expressed in 59 organ(s), highest expression level in skin of abdomen.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   CDD; cd00041; CUB; 2.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 2.60.120.290; -; 2.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   Pfam; PF00431; CUB; 2.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00042; CUB; 2.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF49854; SSF49854; 2.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS01180; CUB; 2.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00059,
KW   ECO:0000256|SAAS:SAAS00037407};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034};
KW   Protease {ECO:0000256|RuleBase:RU363034};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A087X1V8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Serine protease {ECO:0000256|RuleBase:RU363034};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    565       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014013299.
FT   DOMAIN       52    299       Peptidase S1.
FT                                {ECO:0000259|PROSITE:PS50240}.
FT   DOMAIN      311    421       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      431    543       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DISULFID    431    458       {ECO:0000256|PROSITE-ProRule:PRU00059}.
SQ   SEQUENCE   565 AA;  62639 MW;  02891314D22463E8 CRC64;
     MLISRNKLIL LLGIVFFERG KSATLSLPKA PSCGQSLVKV QPWNYFNIFS RILGGSQVEK
     GSYPWQVSLK QRQKHICGGS IVSPQWVITA AHCIANRNIV STLNVTAGEY DLSQTDPGEQ
     TLTIETVIIH PHFSTKKPMD YDIALLKMAG AFQFGHFVGP ICLPELREQF EAGFICTTAG
     WGRLTEGGVL SQVLQEVNLP ILTWEECVAA LLTLKRPISG KTFLCTGFPD GGRDACQGDS
     GGSLMCRNKK GAWTLAGVTS WGLGCGRGWR NNVRKSDQGS PGIFTDISKV LPWIHEHIQT
     GNRRKSSRAW CSEQDVIVSG AEGKLHFPES LHLYYESKQR CVWTLLVPEE MHVLLSFSHL
     DVESCHHSYL SMYSLEDRPI GKFCGESLPS SILIGSNSLR LKFVSDATDN AAGFNLTYKA
     LKPNYIPDSG CSYLTVLFEE GLIQSLNYPE NYSDKANCDW IFQASKHHLI KLSFQSLEIE
     ESGDCTSDYV TVHSDVERKK EIARLCGYDV PTPVLSPSSI MLISFQSDEN GTCRGFQATV
     SFIPKAVYPD LNISISEDES MFLET
//