ID A0A087X1T7_HUMAN Unreviewed; 2473 AA. AC A0A087X1T7; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 13-FEB-2019, entry version 40. DE SubName: Full=Aggrecan core protein {ECO:0000313|Ensembl:ENSP00000484456}; GN Name=ACAN {ECO:0000313|Ensembl:ENSP00000484456}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000484456, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000484456, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16572171; DOI=10.1038/nature04601; RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S., RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., RA Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., RA Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., RA Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., RA Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., RA Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., RA Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., RA Nusbaum C.; RT "Analysis of the DNA sequence and duplication history of human RT chromosome 15."; RL Nature 440:671-675(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000484456} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00323}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC103982; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A087X1T7; -. DR jPOST; A0A087X1T7; -. DR PeptideAtlas; A0A087X1T7; -. DR Ensembl; ENST00000617301; ENSP00000484456; ENSG00000157766. DR UCSC; uc059mya.1; human. DR EuPathDB; HostDB:ENSG00000157766.15; -. DR HGNC; HGNC:319; ACAN. DR OpenTargets; ENSG00000157766; -. DR eggNOG; ENOG410IJP2; Eukaryota. DR eggNOG; ENOG410XRES; LUCA. DR GeneTree; ENSGT00940000155971; -. DR ChiTaRS; ACAN; human. DR Proteomes; UP000005640; Chromosome 15. DR Bgee; ENSG00000157766; Expressed in 160 organ(s), highest expression level in tibia. DR ExpressionAtlas; A0A087X1T7; baseline and differential. DR GO; GO:0005540; F:hyaluronic acid binding; IEA:InterPro. DR GO; GO:0007155; P:cell adhesion; IEA:InterPro. DR CDD; cd00033; CCP; 1. DR CDD; cd03588; CLECT_CSPGs; 1. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.10.100.10; -; 5. DR InterPro; IPR001304; C-type_lectin-like. DR InterPro; IPR016186; C-type_lectin-like/link_sf. DR InterPro; IPR018378; C-type_lectin_CS. DR InterPro; IPR033987; CSPG_CTLD. DR InterPro; IPR016187; CTDL_fold. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR013106; Ig_V-set. DR InterPro; IPR000538; Link_dom. DR InterPro; IPR035976; Sushi/SCR/CCP_sf. DR InterPro; IPR000436; Sushi_SCR_CCP_dom. DR Pfam; PF00059; Lectin_C; 1. DR Pfam; PF00084; Sushi; 1. DR Pfam; PF07686; V-set; 1. DR Pfam; PF00193; Xlink; 4. DR PRINTS; PR01265; LINKMODULE. DR SMART; SM00032; CCP; 1. DR SMART; SM00034; CLECT; 1. DR SMART; SM00409; IG; 1. DR SMART; SM00406; IGv; 1. DR SMART; SM00445; LINK; 4. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF56436; SSF56436; 5. DR SUPFAM; SSF57535; SSF57535; 1. DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1. DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. DR PROSITE; PS01241; LINK_1; 3. DR PROSITE; PS50963; LINK_2; 4. DR PROSITE; PS50923; SUSHI; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00302, KW ECO:0000256|SAAS:SAAS00591625}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00653601}; KW Proteomics identification {ECO:0000213|MaxQB:A0A087X1T7, KW ECO:0000213|PeptideAtlas:A0A087X1T7}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}. FT SIGNAL 1 16 {ECO:0000256|SAM:SignalP}. FT CHAIN 17 2473 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001832193. FT DOMAIN 34 147 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 153 248 Link. {ECO:0000259|PROSITE:PS50963}. FT DOMAIN 254 350 Link. {ECO:0000259|PROSITE:PS50963}. FT DOMAIN 478 573 Link. {ECO:0000259|PROSITE:PS50963}. FT DOMAIN 579 675 Link. {ECO:0000259|PROSITE:PS50963}. FT DOMAIN 2270 2384 C-type lectin. FT {ECO:0000259|PROSITE:PS50041}. FT DOMAIN 2388 2448 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DISULFID 199 220 {ECO:0000256|PROSITE-ProRule:PRU00323}. FT DISULFID 297 318 {ECO:0000256|PROSITE-ProRule:PRU00323}. FT DISULFID 524 545 {ECO:0000256|PROSITE-ProRule:PRU00323}. FT DISULFID 622 643 {ECO:0000256|PROSITE-ProRule:PRU00323}. FT DISULFID 2390 2433 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT DISULFID 2419 2446 {ECO:0000256|PROSITE-ProRule:PRU00302}. SQ SEQUENCE 2473 AA; 255588 MW; C893F22CE591106B CRC64; MTTLLWVFVT LRVITAAVTV ETSDHDNSLS VSIPQPSPLR VLLGTSLTIP CYFIDPMHPV TTAPSTAPLA PRIKWSRVSK EKEVVLLVAT EGRVRVNSAY QDKVSLPNYP AIPSDATLEV QSLRSNDSGV YRCEVMHGIE DSEATLEVVV KGIVFHYRAI STRYTLDFDR AQRACLQNSA IIATPEQLQA AYEDGFHQCD AGWLADQTVR YPIHTPREGC YGDKDEFPGV RTYGIRDTNE TYDVYCFAEE MEGEVFYATS PEKFTFQEAA NECRRLGARL ATTGQLYLAW QAGMDMCSAG WLADRSVRYP ISKARPNCGG NLLGVRTVYV HANQTGYPDP SSRYDAICYT GEDFVDIPEN FFGVGGEEDI TVQTVTWPDM ELPLPRNITE GEARGSVILT VKPIFEVSPS PLEPEEPFTF APEIGATAFA EVENETGEAT RPWGFPTPGL GPATAFTSED LVVQVTAVPG QPHLPGGVVF HYRPGPTRYS LTFEEAQQAC LRTGAVIASP EQLQAAYEAG YEQCDAGWLR DQTVRYPIVS PRTPCVGDKD SSPGVRTYGV RPSTETYDVY CFVDRLEGEV FFATRLEQFT FQEALEFCES HNATLATTGQ LYAAWSRGLD KCYAGWLADG SLRYPIVTPR PACGGDKPGV RTVYLYPNQT GLPDPLSRHH AFCFRGISAV PSPGEEEGGT PTSPSGVEEW IVTQVVPGVA AVPVEEETTA VPSGETTAIL EFTTEPENQT EWEPAYTPVG TSPLPGILPT WPPTGAATEE STEGPSATEV PSASEEPSPS EVPFPSEEPS PSEEPFPSVR PFPSVELFPS EEPFPSKEPS PSEEPSASEE PYTPSPPVPS WTELPSSGEE SGAPDVSGDF TGSGDVSGHL DFSGQLSGDR ASGLPSGDLD SSGLTSTVGS GLPVESGLPS GDEERIEWPS TPTVGELPSG AEILEGSASG VGDLSGLPSG EVLETSASGV GDLSGLPSGE VLETTAPGVE DISGLPSGEV LETTAPGVED ISGLPSGEVL ETTAPGVEDI SGLPSGEVLE TTAPGVEDIS GLPSGEVLET TAPGVEDISG LPSGEVLETA APGVEDISGL PSGEVLETAA PGVEDISGLP SGEVLETAAP GVEDISGLPS GEVLETAAPG VEDISGLPSG EVLETAAPGV EDISGLPSGE VLETAAPGVE DISGLPSGEV LETAAPGVED ISGLPSGEVL ETAAPGVEDI SGLPSGEVLE TAAPGVEDIS GLPSGEVLET AAPGVEDISG LPSGEVLETA APGVEDISGL PSGEVLETAA PGVEDISGLP SGEVLETAAP GVEDISGLPS GEVLETAAPG VEDISGLPSG EVLETAAPGV EDISGLPSGE VLETAAPGVE DISGLPSGEV LETTAPGVEE ISGLPSGEVL ETTAPGVDEI SGLPSGEVLE TTAPGVEEIS GLPSGEVLET STSAVGDLSG LPSGGEVLEI SVSGVEDISG LPSGEVVETS ASGIEDVSEL PSGEGLETSA SGVEDLSRLP SGEEVLEISA SGFGDLSGLP SGGEGLETSA SEVGTDLSGL PSGREGLETS ASGAEDLSGL PSGKEDLVGS ASGDLDLGKL PSGTLGSGQA PETSGLPSGF SGEYSGVDLG SGPPSGLPDF SGLPSGFPTV SLVDSTLVEV VTASTASELE GRGTIGISGA GEISGLPSSE LDISGRASGL PSGTELSGQA SGSPDVSGEI PGLFGVSGQP SGFPDTSGET SGVTELSGLS SGQPGISGEA SGVLYGTSQP FGITDLSGET SGVPDLSGQP SGLPGFSGAT SGVPDLVSGT TSGSGESSGI TFVDTSLVEV APTTFKEEEG LGSVELSGLP SGEADLSGKS GMVDVSGQFS GTVDSSGFTS QTPEFSGLPS GIAEVSGESS RAEIGSSLPS GAYYGSGTPS SFPTVSLVDR TLVESVTQAP TAQEAGEGPS GILELSGAHS GAPDMSGEHS GFLDLSGLQS GLIEPSGEPP GTPYFSGDFA STTNVSGESS VAMGTSGEAS GLPEVTLITS EFVEGVTEPT ISQELGQRPP VTHTPQLFES SGKVSTAGDI SGATPVLPGS GVEVSSVPES SSETSAYPEA GFGASAAPEA SREDSGSPDL SETTSAFHEA NLERSSGLGV SGSTLTFQEG EASAAPEVSG ESTTTSDVGT EAPGLPSATP TASGDRTEIS GDLSGHTSQL GVVISTSIPE SEWTQQTQRP AETHLEIESS SLLYSGEETH TVETATSPTD ASIPASPEWK RESESTAADQ EVCEEGWNKY QGHCYRHFPD RETWVDAERR CREQQSHLSS IVTPEEQEFV NNNAQDYQWI GLNDRTIEGD FRWSDGHPMQ FENWRPNQPD NFFAAGEDCV VMIWHEKGEW NDVPCNYHLP FTCKKGTVAC GEPPVVEHAR TFGQKKDRYE INSLVRYQCT EGFVQRHMPT IRCQPSGHWE EPQITCTDPT TYKRRLQKRS SRHPRRSRPS TAH //