ID   A0A087X1L8_HUMAN        Unreviewed;       192 AA.
AC   A0A087X1L8;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 30.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSP00000484302};
GN   Name=LOC102723996 {ECO:0000313|Ensembl:ENSP00000484302};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000484302, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000484302, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RG   Chromosome 21 mapping and sequencing consortium;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T.,
RA   Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y.,
RA   Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K.,
RA   Polley A., Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D.,
RA   Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W.,
RA   Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S.,
RA   Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E.,
RA   Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P.,
RA   Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H.,
RA   Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E.,
RA   Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F.,
RA   Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [2] {ECO:0000313|Ensembl:ENSP00000484302}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; FP565260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087X1L8; -.
DR   SMR; A0A087X1L8; -.
DR   BioMuta; ENSG00000277117; -.
DR   jPOST; A0A087X1L8; -.
DR   PeptideAtlas; A0A087X1L8; -.
DR   Ensembl; ENST00000620481; ENSP00000484302; ENSG00000277117.
DR   UCSC; uc061ytw.1; human.
DR   EuPathDB; HostDB:ENSG00000277117.4; -.
DR   GeneCards; LOC102723996; -.
DR   OpenTargets; ENSG00000277117; -.
DR   eggNOG; ENOG410IYI6; Eukaryota.
DR   eggNOG; ENOG410Z67K; LUCA.
DR   GeneTree; ENSGT00940000161590; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   Bgee; ENSG00000277117; Expressed in 88 organ(s), highest expression level in heart left ventricle.
DR   ExpressionAtlas; A0A087X1L8; baseline and differential.
DR   GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0042130; P:negative regulation of T cell proliferation; IBA:GO_Central.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   GO; GO:0031295; P:T cell costimulation; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013162; CD80_C2-set.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   Pfam; PF08205; C2-set_2; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00504776};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS01086444};
KW   Membrane {ECO:0000256|SAAS:SAAS00555568, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00555568,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00555568,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    192       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832149.
FT   TRANSMEM    137    160       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       24    110       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   192 AA;  20996 MW;  798F29C02079CABC CRC64;
     MRLGSPGLLF LLFSSLRAAN FSVPVVSAPH SPSQDELTFT CTSINGYPRP NVYWINKTDN
     SLLDQALQND TVFLNMRGLY DVVSVLRIAR TPSVNIGCCI ENVLLQQNLT VGSQTGNDIG
     ERDKITENPV STGEKNAATW SILAVLCLLV VVAVAIGWVC RDRCLQHSYA GAWAVSPETE
     LTESWNLLLL LS
//