ID   A0A087X1J7_HUMAN        Unreviewed;       225 AA.
AC   A0A087X1J7;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 27.
DE   RecName: Full=Glutathione peroxidase {ECO:0000256|RuleBase:RU000499};
GN   Name=GPX3 {ECO:0000313|Ensembl:ENSP00000484258};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000484258, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000484258, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000484258}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
CC       {ECO:0000256|RuleBase:RU000499}.
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DR   EMBL; AC008641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087X1J7; -.
DR   SMR; A0A087X1J7; -.
DR   EPD; A0A087X1J7; -.
DR   jPOST; A0A087X1J7; -.
DR   PeptideAtlas; A0A087X1J7; -.
DR   Ensembl; ENST00000622181; ENSP00000484258; ENSG00000211445.
DR   UCSC; uc063itg.1; human.
DR   EuPathDB; HostDB:ENSG00000211445.11; -.
DR   HGNC; HGNC:4555; GPX3.
DR   OpenTargets; ENSG00000211445; -.
DR   eggNOG; KOG1651; Eukaryota.
DR   eggNOG; COG0386; LUCA.
DR   GeneTree; ENSGT00940000161754; -.
DR   ChiTaRS; GPX3; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000211445; Expressed in 236 organ(s), highest expression level in thyroid gland.
DR   ExpressionAtlas; A0A087X1J7; baseline and differential.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:InterPro.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd00340; GSH_Peroxidase; 1.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR029760; GPX_CS.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR11592; PTHR11592; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000499};
KW   Peroxidase {ECO:0000256|RuleBase:RU000499};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A087X1J7,
KW   ECO:0000213|PeptideAtlas:A0A087X1J7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    225       Glutathione peroxidase.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832210.
SQ   SEQUENCE   225 AA;  25402 MW;  89B0722D210F1194 CRC64;
     MARLLQASCL LSLLLAGFVS QSRGQEKSKM DCHGGISGTI YEYGALTIDG EEYIPFKQYA
     GKYVLFVNVA SYGLTGQYIE LNALQEELAP FGLVILGFPC NQFGKQEPGE NSEILPTLKY
     VRPGGGFVPN FQLFEKGDVN GEKEQKFYTF LKNSCPPTSE LLGTSDRLFW EPMKVHDIRW
     NFEKFLVGPD GIPIMRWHHR TTVSNVKMDI LSYMRRQAAL GVKRK
//