ID   A0A087X1F1_HUMAN        Unreviewed;       398 AA.
AC   A0A087X1F1;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   12-SEP-2018, entry version 22.
DE   SubName: Full=Mucosal addressin cell adhesion molecule 1 {ECO:0000313|Ensembl:ENSP00000484153};
GN   Name=MADCAM1 {ECO:0000313|Ensembl:ENSP00000484153};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000484153, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000484153, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000484153}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC005775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087X1F1; -.
DR   PeptideAtlas; A0A087X1F1; -.
DR   Ensembl; ENST00000619333; ENSP00000484153; ENSG00000099866.
DR   UCSC; uc060qoj.1; human.
DR   EuPathDB; HostDB:ENSG00000099866.14; -.
DR   HGNC; HGNC:6765; MADCAM1.
DR   OpenTargets; ENSG00000099866; -.
DR   eggNOG; ENOG410J133; Eukaryota.
DR   eggNOG; ENOG411140D; LUCA.
DR   GeneTree; ENSGT00510000049549; -.
DR   ChiTaRS; MADCAM1; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000099866; Expressed in 131 organ(s), highest expression level in vermiform appendix.
DR   ExpressionAtlas; A0A087X1F1; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0098640; F:integrin binding involved in cell-matrix adhesion; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR   GO; GO:2000403; P:positive regulation of lymphocyte migration; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR015169; Adhes-Ig-like.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR037413; MADCAM1.
DR   PANTHER; PTHR14162; PTHR14162; 2.
DR   Pfam; PF09085; Adhes-Ig_like; 1.
DR   ProDom; PD336606; Adhes-Ig-like; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A087X1F1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    398       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832177.
FT   DOMAIN       25     94       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   398 AA;  41798 MW;  E4DA26A2432E05DE CRC64;
     MDFGLALLLA GLLGLLLGQS LQVKPLQVEP PEPVVAVALG ASRQLTCRLA CADRGASVQW
     RGLDTSLGAV QSDTGRSVLT VRNASLSAAG TRVCVGSCGG RTFQHTVQLL VYAFPDQLTV
     SPAALVPGDP EVACTAHKVT PVDPNALSFS LLVGGQELEG AQALGPEVQE EEEEPQGDED
     VLFRVTERWR LPPLGTPVPP ALYCQATMRL PGLELSHRQA IPALHGWLSP PPPQNTGPHG
     PHPTSPEPPD TTSPESPDTT SPESPDTTSQ EPPDTTSPEP PDKTSPEPAP QQGSTHTPRS
     PGSTRTRRPE ISQAGPTQGE VIPTGSSKPA GDQLPAALWT SSAVLGLLLL ALPTYHLWKR
     CRHLAEDDTH PPASLRLLPQ VSAWAGLRGT GQVGISPS
//