ID   A0A087X1B3_HUMAN        Unreviewed;       292 AA.
AC   A0A087X1B3;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   07-NOV-2018, entry version 24.
DE   SubName: Full=Transmembrane protein 178B {ECO:0000313|Ensembl:ENSP00000484025};
GN   Name=TMEM178B {ECO:0000313|Ensembl:ENSP00000484025};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000484025, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000484025, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000484025}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC004928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC006362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC006396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC073878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PeptideAtlas; A0A087X1B3; -.
DR   Ensembl; ENST00000610315; ENSP00000484025; ENSG00000261115.
DR   UCSC; uc064iqe.1; human.
DR   EuPathDB; HostDB:ENSG00000261115.5; -.
DR   HGNC; HGNC:44112; TMEM178B.
DR   OpenTargets; ENSG00000261115; -.
DR   eggNOG; ENOG410IEXN; Eukaryota.
DR   eggNOG; ENOG410YC3G; LUCA.
DR   GeneTree; ENSGT00390000015299; -.
DR   ChiTaRS; TMEM178B; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000261115; Expressed in 159 organ(s), highest expression level in cardiac muscle of right atrium.
DR   ExpressionAtlas; A0A087X1B3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR039625; T178A/B.
DR   PANTHER; PTHR32005; PTHR32005; 1.
DR   Pfam; PF13903; Claudin_2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00463381, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A087X1B3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00463381,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00463381,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    292       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832172.
FT   TRANSMEM    170    193       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    200    226       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    246    270       Helical. {ECO:0000256|SAM:Phobius}.
FT   COILED       65     85       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   292 AA;  33173 MW;  6A64FAFEE5A0971A CRC64;
     MAAGRLLLYT GLSLALCALG MLAVAICSDH WYETDARKHR DRCKAFNTRR VDPGFIYNNN
     NNLPLRASRS RLDRWEGKLL RARNRRQLFA MSPADECSRQ YNSTNMGLWR KCHRQGFDPE
     IAALIRKGEI ERCTYIKYHY SSATIPRNLT FNVTKTLRCM YCMYLRRMTA GFMGMAVAII
     LFGWIIGVLG CCWDRGLMQY VAGLLFLMGG TFCIISLCTC VAGINFELSR YPRYLYGLPD
     DISHGYGWSM FCAWGGLGLT LISGFFCTLA PSVQPVPRTN YPKSRPENGT VC
//