ID   A0A087X162_HUMAN        Unreviewed;       295 AA.
AC   A0A087X162;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 30.
DE   SubName: Full=Growth hormone receptor {ECO:0000313|Ensembl:ENSP00000483926};
GN   Name=GHR {ECO:0000313|Ensembl:ENSP00000483926};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000483926, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000483926, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000483926}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC093225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC113368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC114941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC116343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC876969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001229391.1; NM_001242462.1.
DR   UniGene; Hs.125180; -.
DR   UniGene; Hs.684632; -.
DR   UniGene; Hs.688223; -.
DR   ProteinModelPortal; A0A087X162; -.
DR   SMR; A0A087X162; -.
DR   PeptideAtlas; A0A087X162; -.
DR   PRIDE; A0A087X162; -.
DR   Ensembl; ENST00000622294; ENSP00000483926; ENSG00000112964.
DR   GeneID; 2690; -.
DR   UCSC; uc021xyc.1; human.
DR   CTD; 2690; -.
DR   EuPathDB; HostDB:ENSG00000112964.13; -.
DR   HGNC; HGNC:4263; GHR.
DR   OpenTargets; ENSG00000112964; -.
DR   eggNOG; ENOG410IFQI; Eukaryota.
DR   eggNOG; ENOG410XTHJ; LUCA.
DR   GeneTree; ENSGT00940000159987; -.
DR   OrthoDB; 346239at2759; -.
DR   ChiTaRS; GHR; human.
DR   GenomeRNAi; 2690; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000112964; Expressed in 192 organ(s), highest expression level in adipose tissue.
DR   ExpressionAtlas; A0A087X162; baseline and differential.
DR   GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:HPA.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR015152; Growth/epo_recpt_lig-bind.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003528; Long_hematopoietin_rcpt_CS.
DR   Pfam; PF09067; EpoR_lig-bind; 1.
DR   Pfam; PF00041; fn3; 1.
DR   SUPFAM; SSF49265; SSF49265; 2.
DR   PROSITE; PS50853; FN3; 1.
DR   PROSITE; PS01352; HEMATOPO_REC_L_F1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A087X162};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    295       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832170.
FT   TRANSMEM    264    287       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      151    254       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
SQ   SEQUENCE   295 AA;  34045 MW;  98B1DD31AAC8F6FD CRC64;
     MDLWQLLLTL ALAGSSDAFS GSEATAAILS RAPWSLQSVN PGLKTNSSKE PKFTKCRSPE
     RETFSCHWTD EVHHGTKNLG PIQLFYTRRN TQEWTQEWKE CPDYVSAGEN SCYFNSSFTS
     IWIPYCIKLT SNGGTVDEKC FSVDEIVQPD PPIALNWTLL NVSLTGIHAD IQVRWEAPRN
     ADIQKGWMVL EYELQYKEVN ETKWKMMDPI LTTSVPVYSL KVDKEYEVRV RSKQRNSGNY
     GEFSEVLYVT LPQMSQFTCE EDFYFPWLLI IIFGIFGLTV MLFVFLFSKQ QRKEN
//