ID   A0A087X0X9_HUMAN        Unreviewed;       254 AA.
AC   A0A087X0X9;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   05-DEC-2018, entry version 23.
DE   SubName: Full=Pro-neuregulin-1, membrane-bound isoform {ECO:0000313|Ensembl:ENSP00000483727};
GN   Name=NRG1 {ECO:0000313|Ensembl:ENSP00000483727};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000483727, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000483727, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000483727}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC021909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC022833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC022850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC023948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC068931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC104000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC104029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087X0X9; -.
DR   SMR; A0A087X0X9; -.
DR   PeptideAtlas; A0A087X0X9; -.
DR   Ensembl; ENST00000614767; ENSP00000483727; ENSG00000157168.
DR   UCSC; uc064lul.1; human.
DR   EuPathDB; HostDB:ENSG00000157168.18; -.
DR   HGNC; HGNC:7997; NRG1.
DR   OpenTargets; ENSG00000157168; -.
DR   GeneTree; ENSGT00940000157326; -.
DR   ChiTaRS; NRG1; human.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000157168; Expressed in 151 organ(s), highest expression level in oocyte.
DR   ExpressionAtlas; A0A087X0X9; baseline and differential.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     50       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        51    254       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832187.
SQ   SEQUENCE   254 AA;  26467 MW;  36C04D38113A3E50 CRC64;
     MRWRRAPRRS GRPGPRAQRP GSAARSSPPL PLLPLLLLLG TAALAPGAAA GNEAAPAGAS
     VCYSSPPSVG SVQELAQRAA VVIEGKVHPQ RRQQGALDRK AAAAAGEAGA WGGDREPPAA
     GPRALGPPAE EPLLAANGTV PSWPTAPVPS AGEPGEEAPY LVKVHQVWAV KAGGLKKDSL
     LTVRLGTWGH PAFPSCGRLK EDSRYIFFME PDANSTSRAP AAFRASFPPL ETGRNLKKEV
     SRVLCKRCAF PPGL
//