ID   A0A087X0U8_HUMAN        Unreviewed;       400 AA.
AC   A0A087X0U8;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   12-SEP-2018, entry version 22.
DE   SubName: Full=Mucosal addressin cell adhesion molecule 1 {ECO:0000313|Ensembl:ENSP00000483663};
GN   Name=MADCAM1 {ECO:0000313|Ensembl:ENSP00000483663};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000483663, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000483663, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000483663}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC005775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A087X0U8; -.
DR   PeptideAtlas; A0A087X0U8; -.
DR   Ensembl; ENST00000621286; ENSP00000483663; ENSG00000099866.
DR   UCSC; uc060qol.1; human.
DR   EuPathDB; HostDB:ENSG00000099866.14; -.
DR   HGNC; HGNC:6765; MADCAM1.
DR   OpenTargets; ENSG00000099866; -.
DR   eggNOG; ENOG410J133; Eukaryota.
DR   eggNOG; ENOG411140D; LUCA.
DR   GeneTree; ENSGT00510000049549; -.
DR   ChiTaRS; MADCAM1; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000099866; Expressed in 131 organ(s), highest expression level in vermiform appendix.
DR   ExpressionAtlas; A0A087X0U8; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0098640; F:integrin binding involved in cell-matrix adhesion; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR   GO; GO:2000403; P:positive regulation of lymphocyte migration; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR015169; Adhes-Ig-like.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR037413; MADCAM1.
DR   PANTHER; PTHR14162; PTHR14162; 2.
DR   Pfam; PF09085; Adhes-Ig_like; 1.
DR   ProDom; PD336606; Adhes-Ig-like; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A087X0U8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    400       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832124.
FT   DOMAIN       25     94       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   400 AA;  42239 MW;  3E6C2DFE058556F0 CRC64;
     MDFGLALLLA GLLGLLLGQS LQVKPLQVEP PEPVVAVALG ASRQLTCRLA CADRGASVQW
     RGLDTSLGAV QSDTGRSVLT VRNASLSAAG TRVCVGSCGG RTFQHTVQLL VYAFPDQLTV
     SPAALVPGDP EVACTAHKVT PVDPNALSFS LLVGGQELEG AQALGPEVQE EEEEPQGDED
     VLFRVTERWR LPPLGTPVPP ALYCQATMRL PGLELSHRQA IPVRWVPWRP TRSPALTSTS
     ESHSPTSPEP PDTTSPESPD TTSPESPDTT SQEPPDTTSP EPPDKTSPEP APQQGSTHTP
     RSPGSTRTRR PEISQAGPTQ GEVIPTGSSK PAGDQLPAAL WTSSAVLGLL LLALPTYHLW
     KRCRHLAEDD THPPASLRLL PQVSAWAGLR GTGQVGISPS
//