ID   A0A087X0K8_HUMAN        Unreviewed;      2367 AA.
AC   A0A087X0K8;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 30.
DE   SubName: Full=Probable G-protein-coupled receptor 179 {ECO:0000313|Ensembl:ENSP00000483469};
GN   Name=GPR179 {ECO:0000313|Ensembl:ENSP00000483469};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000483469, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000483469, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000483469}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC244092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001004334.3; NM_001004334.3.
DR   UniGene; Hs.462915; -.
DR   ProteinModelPortal; A0A087X0K8; -.
DR   jPOST; A0A087X0K8; -.
DR   PeptideAtlas; A0A087X0K8; -.
DR   PRIDE; A0A087X0K8; -.
DR   Ensembl; ENST00000616987; ENSP00000483469; ENSG00000277399.
DR   GeneID; 440435; -.
DR   KEGG; hsa:440435; -.
DR   UCSC; uc002hpz.3; human.
DR   CTD; 440435; -.
DR   EuPathDB; HostDB:ENSG00000277399.4; -.
DR   HGNC; HGNC:31371; GPR179.
DR   OpenTargets; ENSG00000277399; -.
DR   eggNOG; KOG4418; Eukaryota.
DR   eggNOG; ENOG410XXEC; LUCA.
DR   GeneTree; ENSGT00940000160776; -.
DR   KO; K22961; -.
DR   OrthoDB; 63351at2759; -.
DR   GenomeRNAi; 440435; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000277399; Expressed in 69 organ(s), highest expression level in caudate nucleus.
DR   ExpressionAtlas; A0A087X0K8; baseline and differential.
DR   GO; GO:0044292; C:dendrite terminus; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR   GO; GO:0007601; P:visual perception; IEA:InterPro.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR032964; GPR179.
DR   PANTHER; PTHR32546:SF7; PTHR32546:SF7; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00500858, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00500858,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00500858,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26   2367       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832113.
FT   TRANSMEM    378    403       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    415    438       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    450    469       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    490    513       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    544    564       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    606    628       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      380    650       G_PROTEIN_RECEP_F3_4.
FT                                {ECO:0000259|PROSITE:PS50259}.
SQ   SEQUENCE   2367 AA;  257344 MW;  F12BDEA0C746A2F2 CRC64;
     MGTRGAVMPP PMWGLLGCCF VCAWALGGPR PIRSLPPLSS QVKPGSVPMQ VPLEGAEAAL
     AYLYSGDAQQ LSQVNCSERY EARGAGAMPG LPPSLQGAAG TLAQAANFLN MLLQANDIRE
     SSVEEDVEWY QALVRSVAEG DPRVYRALLT FNPPPGASHL QLALQATRTG EETILQDLSG
     NWVQEENPPG DLDTPALKKR VLTNDLGSLG SPKWPQADGY VGDTQQVRLS PPFLECQEGR
     LRPGWLITLS ATFYGLKPDL SPEVRGQVQM DVDLQSVDIN QCASGPGWYS NTHLCDLNST
     QCVPLESQGF VLGRYLCRCR PGFYGASPSG GLEESDFQTT GQFGFPEGRS GRLLQCLPCP
     EGCTSCMDAT PCLVEEAAVL RAAVLACQAC CMLAIFLSML VSYRCRRNKR IWASGVVLLE
     TVLFGFLLLY FPVFILYFKP SVFRCIALRW VRLLGFAIVY GTIILKLYRV LQLFLSRTAQ
     RSALLSSGRL LRHLGLLLLP VLGFLAVWTV GALERGIQHA PLVIRGHTPS GRHFYLCHHD
     RWDYIMVVAE LLLLCWGSFL CYATRAVLSA FHEPRYMGIA LHNELLLSAA FHTARFVLVP
     SLHPDWTLLL FFFHTHSTVT TTLALIFIPK FWKLGAPPRE EMVDEVCEDE LDLQHSGSYL
     GSSIASAWSE HSLDPGDIRD ELKKLYAQLE VHKTKEMAAN NPHLPKKRGS SCQGLGRSFM
     RYLAEFPEAL ARQHSRDSGS PGHGSLPGSS RRRLLSSSLQ EPEGTPALHK SRSTYDQRRE
     QDPPLLDSLL RRKLAKKASR TESRESVEGP PALGFRSASA HNLTVGERLP RARPASLQKS
     LSVASSREKA LLMASQAYLE ETYRQAKERE ERKKAKAAMA SLVRRPSARR LERPRGAPLS
     APPSPAKSSS VDSSHTSGRL HEEARRRLPH PPIRHQVSTP ILALSGGLGE PRMLSPTSTL
     APALLPALAP TPAPALAPVP VSPQSPNLLT YICPWENAEL PAKQENVPQE GPSGPERGHH
     SPAPARARLW RALSVAVEKS RAGENEMDAE DAHHQREAND VDEDRPKIFP KSHSLKAPVQ
     QGSMRSLGLA IKALTRSRST YREKESVEES PEGQNSGTAG ESMGAPSRSP RLGRPKAVSK
     QAALIPSDDK ESLQNQQNAH TSRMLQVCQR EGSREQEDRG RRMTQGLGER KAERAGKTGL
     AMLRQVSRDK NIKQSKETPV GWQELPKAGL QSLGSADHRV AEVCPWEVTE SETRQPDSGN
     KAEICPWETS EGAPESRALR QDPGDSQKKR GEARGKSEPI DVVPMMRKKP ERLVREQEAV
     CPWESADRGG LSPGSAPQDP GRIRDKSEAG DSVEARKVEK PGWEAAGPEA HTPDITKAEP
     CPWEASEGGE DGKPAQEAVK DLPQEKQKTR KATFWKEQKP GGDLESLCPW ESTDFRGPSA
     VSIQAPGSSE CSGSLGSGIA EVCLWEAGDA PAIQKAEICP WELDDNVMGQ EMLSLGTGRE
     SLQEKEKASR KGSFGEMGEQ TVKAVQKLSQ QQESVCPRES TVPGHSSPCL DNSSSKAGSQ
     FLCNGGSRAT QVCPQEDLRP EAQEATPAKT EICPWEVNER TREEWTSAQV PRGGESQKDK
     EKMPGKSEIE DVTAWEKPEG QIQKQEAVGP WESVDPGSFS PQPRPQDTER PQTLLQMSGS
     VGSKAADICP LDVEENLTAG KAEICPWEVG AGAGEERALG AEAIRKSPND TGKVSADLGP
     RERAVTAPEK PQKPTPEWEV ACPWGSVGPG ACSQHPGTLD ADGPKAGFQE LDHMGCRPGE
     VCPWEAQEAA TSEKAKICPW EVSEGTTGKG LDQKAGSESA EQREKALEKG RLTSLGEDVS
     KGMAKLCQQQ ETICIWENKD LRESPAQAPK ISDLPSSMSS EVAEGHSLEA TEKGDLRQDP
     KTGSFPEHIT QEKAPAADTE EFTTEDGEKT SHELQSVCPW ETTAPADSVS HLDRQRPDQP
     KASSQRLVST GGRAADVCPW DVPDAGVYKS DSSAKAETCP WEVTERIPVK GVSRQDGKGD
     SQEEKGRAPE KSEPKGVPVQ KKPEMADFRQ QEAVCPWESQ DGKGLSPQPA PDASDRSRGS
     SEAAGSVETR VAEVCLWEVV EAPSAKKAEI CPWEAGGGAA EEGEQERESQ GQGEMFLQKA
     GPGGTEEHFS KAAAKPREQE AVCPGEGTGS GGLLPQSGAL DPELKVSPKE AGSMGSRMAE
     LCQWEITDPE GNKIKGTMAD ICPGEETGVP SEESGLLALT ATRREFFPTA PEKPLCLLVH
     GPLDHFFPES KIPCPKVSRP ASTFTLEGVR ELQGPSGLEP RTSLAPEPSL QEAESQSSSL
     TEDSGQVAFE AQYEEFTPPT VYPWDWE
//