ID A0A087X0I2_HUMAN Unreviewed; 378 AA. AC A0A087X0I2; DT 29-OCT-2014, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 1. DT 16-JAN-2019, entry version 36. DE SubName: Full=Complement factor I {ECO:0000313|Ensembl:ENSP00000483416}; GN Name=CFI {ECO:0000313|Ensembl:ENSP00000483416}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000483416, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000483416, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [3] {ECO:0000313|Ensembl:ENSP00000483416} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2014) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC126283; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A087X0I2; -. DR jPOST; A0A087X0I2; -. DR PeptideAtlas; A0A087X0I2; -. DR Ensembl; ENST00000618244; ENSP00000483416; ENSG00000205403. DR UCSC; uc062yzc.1; human. DR EuPathDB; HostDB:ENSG00000205403.12; -. DR HGNC; HGNC:5394; CFI. DR OpenTargets; ENSG00000205403; -. DR eggNOG; KOG3627; Eukaryota. DR eggNOG; COG5640; LUCA. DR GeneTree; ENSGT00930000151042; -. DR Proteomes; UP000005640; Chromosome 4. DR Bgee; ENSG00000205403; Expressed in 177 organ(s), highest expression level in visceral pleura. DR ExpressionAtlas; A0A087X0I2; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:InterPro. DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro. DR CDD; cd00112; LDLa; 2. DR Gene3D; 3.10.250.10; -; 1. DR InterPro; IPR003884; FacI_MAC. DR InterPro; IPR002350; Kazal_dom. DR InterPro; IPR036058; Kazal_dom_sf. DR InterPro; IPR036055; LDL_receptor-like_sf. DR InterPro; IPR023415; LDLR_class-A_CS. DR InterPro; IPR002172; LDrepeatLR_classA_rpt. DR InterPro; IPR001190; SRCR. DR InterPro; IPR017448; SRCR-like_dom. DR InterPro; IPR036772; SRCR-like_dom_sf. DR Pfam; PF00057; Ldl_recept_a; 2. DR Pfam; PF00530; SRCR; 1. DR PRINTS; PR00261; LDLRECEPTOR. DR SMART; SM00057; FIMAC; 1. DR SMART; SM00192; LDLa; 2. DR SMART; SM00202; SR; 1. DR SUPFAM; SSF100895; SSF100895; 1. DR SUPFAM; SSF56487; SSF56487; 1. DR SUPFAM; SSF57424; SSF57424; 2. DR PROSITE; PS51465; KAZAL_2; 1. DR PROSITE; PS01209; LDLRA_1; 1. DR PROSITE; PS50068; LDLRA_2; 2. DR PROSITE; PS50287; SRCR_2; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124, KW ECO:0000256|SAAS:SAAS01050632}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 378 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5001832142. FT DOMAIN 60 108 Kazal-like. FT {ECO:0000259|PROSITE:PS51465}. FT DOMAIN 114 215 SRCR. {ECO:0000259|PROSITE:PS50287}. FT DISULFID 186 196 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 229 247 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 241 256 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 259 271 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 266 284 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 278 293 {ECO:0000256|PROSITE-ProRule:PRU00124}. SQ SEQUENCE 378 AA; 42519 MW; 915C7157D8EDC7D0 CRC64; MKLLHVFLLF LCFHLRFCKV TYTSQEDLVE KKCLAKKYTH LSCDKVFCQP WQRCIEGTCV CKLPYQCPKN GTAVCATNRR SFPTYCQQKS LECLHPGTKF LNNGTCTAEG KFSVSLKHGN TDSEGIVEVK LVDQDKTMFI CKSSWSMREA NVACLDLGFQ QGADTQRRFK LSDLSINSTE CLHVHCRGLE TSLAECTFTK RRTMGYQDFA DVVCYTQKAD SPMDDFFQCV NGKYISQMKA CDGINDCGDQ SDELCCKACQ GKGFHCKSGV CIPSQYQCNG EVDCITGEDE VGCAGFASVT QEETEILTAD MDAERRRIKS LLPKLSCGVK NRMHIRRKRI VGGKRAQLGG KMKQISLDIF KGLHRVYAIL EFCCIILK //