ID   A0A087X0H5_HUMAN        Unreviewed;       645 AA.
AC   A0A087X0H5;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   13-FEB-2019, entry version 35.
DE   SubName: Full=Growth hormone receptor {ECO:0000313|Ensembl:ENSP00000483403};
GN   Name=GHR {ECO:0000313|Ensembl:ENSP00000483403};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000483403, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000483403, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [3] {ECO:0000313|Ensembl:ENSP00000483403}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AC093225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC113368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC114941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC116343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC876969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001229328.1; NM_001242399.2.
DR   UniGene; Hs.125180; -.
DR   UniGene; Hs.684632; -.
DR   UniGene; Hs.688223; -.
DR   ProteinModelPortal; A0A087X0H5; -.
DR   SMR; A0A087X0H5; -.
DR   PRIDE; A0A087X0H5; -.
DR   Ensembl; ENST00000620156; ENSP00000483403; ENSG00000112964.
DR   GeneID; 2690; -.
DR   UCSC; uc021xxv.1; human.
DR   CTD; 2690; -.
DR   EuPathDB; HostDB:ENSG00000112964.13; -.
DR   HGNC; HGNC:4263; GHR.
DR   OpenTargets; ENSG00000112964; -.
DR   eggNOG; ENOG410IFQI; Eukaryota.
DR   eggNOG; ENOG410XTHJ; LUCA.
DR   GeneTree; ENSGT00940000159987; -.
DR   OMA; WIVLEYE; -.
DR   OrthoDB; 346239at2759; -.
DR   ChiTaRS; GHR; human.
DR   GenomeRNAi; 2690; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000112964; Expressed in 192 organ(s), highest expression level in adipose tissue.
DR   ExpressionAtlas; A0A087X0H5; baseline and differential.
DR   GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:HPA.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   GO; GO:0004903; F:growth hormone receptor activity; IEA:Ensembl.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
DR   GO; GO:0042169; F:SH2 domain binding; IEA:Ensembl.
DR   GO; GO:0042976; P:activation of Janus kinase activity; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; IEA:Ensembl.
DR   GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
DR   GO; GO:0060396; P:growth hormone receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1901215; P:negative regulation of neuron death; IEA:Ensembl.
DR   GO; GO:0045597; P:positive regulation of cell differentiation; IEA:Ensembl.
DR   GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR   GO; GO:0032094; P:response to food; IEA:Ensembl.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   GO; GO:0070555; P:response to interleukin-1; IEA:Ensembl.
DR   GO; GO:0043278; P:response to morphine; IEA:Ensembl.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR025871; GHBP.
DR   InterPro; IPR015152; Growth/epo_recpt_lig-bind.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003528; Long_hematopoietin_rcpt_CS.
DR   Pfam; PF09067; EpoR_lig-bind; 1.
DR   Pfam; PF00041; fn3; 1.
DR   Pfam; PF12772; GHBP; 1.
DR   SUPFAM; SSF49265; SSF49265; 2.
DR   PROSITE; PS50853; FN3; 1.
DR   PROSITE; PS01352; HEMATOPO_REC_L_F1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A087X0H5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    645       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832168.
FT   TRANSMEM    271    294       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      158    261       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
SQ   SEQUENCE   645 AA;  72243 MW;  D757356B10C5D250 CRC64;
     MNWGPTGMDL WQLLLTLALA GSSDAFSGSE ATAAILSRAP WSLQSVNPGL KTNSSKEPKF
     TKCRSPERET FSCHWTDEVH HGTKNLGPIQ LFYTRRNTQE WTQEWKECPD YVSAGENSCY
     FNSSFTSIWI PYCIKLTSNG GTVDEKCFSV DEIVQPDPPI ALNWTLLNVS LTGIHADIQV
     RWEAPRNADI QKGWMVLEYE LQYKEVNETK WKMMDPILTT SVPVYSLKVD KEYEVRVRSK
     QRNSGNYGEF SEVLYVTLPQ MSQFTCEEDF YFPWLLIIIF GIFGLTVMLF VFLFSKQQRI
     KMLILPPVPV PKIKGIDPDL LKEGKLEEVN TILAIHDSYK PEFHSDDSWV EFIELDIDEP
     DEKTEESDTD RLLSSDHEKS HSNLGVKDGD SGRTSCCEPD ILETDFNAND IHEGTSEVAQ
     PQRLKGEADL LCLDQKNQNN SPYHDACPAT QQPSVIQAEK NKPQPLPTEG AESTHQAAHI
     QLSNPSSLSN IDFYAQVSDI TPAGSVVLSP GQKNKAGMSQ CDMHPEMVSL CQENFLMDNA
     YFCEADAKKC IPVAPHIKVE SHIQPSLNQE DIYITTESLT TAAGRPGTGE HVPGSEMPVP
     DYTSIHIVQS PQGLILNATA LPLPDKEFLS SCGYVSTDQL NKIMP
//