ID   A0A087X089_HUMAN        Unreviewed;       115 AA.
AC   A0A087X089;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 32.
DE   RecName: Full=C-C motif chemokine {ECO:0000256|RuleBase:RU361150};
GN   Name=CCL14 {ECO:0000313|Ensembl:ENSP00000483186};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000483186, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000483186, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000483186}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSP00000488545}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361150}.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000256|RuleBase:RU361150, ECO:0000256|SAAS:SAAS00582068}.
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DR   EMBL; AC004675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC244100; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9606.ENSP00000409197; -.
DR   PeptideAtlas; A0A087X089; -.
DR   Ensembl; ENST00000614009; ENSP00000483186; ENSG00000276409.
DR   Ensembl; ENST00000633434; ENSP00000488545; ENSG00000277236.
DR   UCSC; uc060eew.1; human.
DR   EuPathDB; HostDB:ENSG00000276409.4; -.
DR   HGNC; HGNC:10612; CCL14.
DR   OpenTargets; ENSG00000276409; -.
DR   eggNOG; ENOG410J09X; Eukaryota.
DR   eggNOG; ENOG410ZD2W; LUCA.
DR   GeneTree; ENSGT00940000153198; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000276409; Expressed in 89 organ(s), highest expression level in spleen.
DR   ExpressionAtlas; A0A087X089; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   1: Evidence at protein level;
KW   Chemotaxis {ECO:0000256|RuleBase:RU361150};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Cytokine {ECO:0000256|RuleBase:RU361150,
KW   ECO:0000256|SAAS:SAAS00582046};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A087X089,
KW   ECO:0000213|PeptideAtlas:A0A087X089};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|RuleBase:RU361150};
KW   Signal {ECO:0000256|RuleBase:RU361150}.
FT   SIGNAL        1     23       {ECO:0000256|RuleBase:RU361150}.
FT   CHAIN        24    115       C-C motif chemokine.
FT                                {ECO:0000256|RuleBase:RU361150}.
FT                                /FTId=PRO_5013979890.
FT   DOMAIN       54    112       SCY. {ECO:0000259|SMART:SM00199}.
SQ   SEQUENCE   115 AA;  13060 MW;  53701720DB685BA6 CRC64;
     MRKAYSPLQV LRGCLLLPSL LHALSLQEQP MVWPLTRGPS SASDALSSGG PYHPSECCFT
     YTTYKIPRQR IMDYYETNSQ CSKPGIVFIT KRGHSVCTNP SDKWVQDYIK DMKEN
//