ID   A0A087WZY5_HUMAN        Unreviewed;      1666 AA.
AC   A0A087WZY5;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   16-JAN-2019, entry version 39.
DE   SubName: Full=Collagen alpha-6(IV) chain {ECO:0000313|Ensembl:ENSP00000482970};
GN   Name=COL4A6 {ECO:0000313|Ensembl:ENSP00000482970};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000482970, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000482970, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA   Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA   Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA   Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA   Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA   Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA   Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA   Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA   Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA   Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA   Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA   Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA   Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA   Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA   Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA   Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA   Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA   Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA   Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA   Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA   Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA   Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA   Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA   Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA   de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA   Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA   Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA   Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA   Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA   Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA   Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA   Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA   Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA   Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA   Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA   Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA   Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA   Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA   Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA   Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA   Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA   Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA   Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA   Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000482970}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
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DR   EMBL; AL031177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL034369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL109943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL136080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001274688.1; NM_001287759.1.
DR   UniGene; Hs.145586; -.
DR   ProteinModelPortal; A0A087WZY5; -.
DR   SMR; A0A087WZY5; -.
DR   EPD; A0A087WZY5; -.
DR   MaxQB; A0A087WZY5; -.
DR   PRIDE; A0A087WZY5; -.
DR   Ensembl; ENST00000621266; ENSP00000482970; ENSG00000197565.
DR   GeneID; 1288; -.
DR   UCSC; uc011msn.4; human.
DR   CTD; 1288; -.
DR   EuPathDB; HostDB:ENSG00000197565.15; -.
DR   HGNC; HGNC:2208; COL4A6.
DR   OpenTargets; ENSG00000197565; -.
DR   eggNOG; KOG3544; Eukaryota.
DR   eggNOG; ENOG410YAVF; LUCA.
DR   GeneTree; ENSGT00940000153991; -.
DR   OrthoDB; 63831at2759; -.
DR   ChiTaRS; COL4A6; human.
DR   GenomeRNAi; 1288; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   Bgee; ENSG00000197565; Expressed in 152 organ(s), highest expression level in esophagus.
DR   ExpressionAtlas; A0A087WZY5; baseline and differential.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR   Gene3D; 2.170.240.10; -; 1.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR001442; Collagen_IV_NC.
DR   InterPro; IPR036954; Collagen_IV_NC_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   Pfam; PF01413; C4; 2.
DR   Pfam; PF01391; Collagen; 18.
DR   SMART; SM00111; C4; 2.
DR   SUPFAM; SSF56436; SSF56436; 2.
DR   PROSITE; PS51403; NC1_IV; 1.
PE   1: Evidence at protein level;
KW   Collagen {ECO:0000256|SAAS:SAAS00762088};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS01066595};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A087WZY5,
KW   ECO:0000213|PeptideAtlas:A0A087WZY5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22   1666       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001832103.
FT   DOMAIN     1442   1666       Collagen IV NC1.
FT                                {ECO:0000259|PROSITE:PS51403}.
SQ   SEQUENCE   1666 AA;  161331 MW;  F39A7D32DDEADF19 CRC64;
     MHPGLWLLLV TLCLTEELAA AGEKSYGKPC GGQDCSGSCQ CFPEKGARGR PGPIGIQGPT
     GPQGFTGSTG LSGLKGERGF PGLLGPYGPK GDKGPMGVPG FLGINGIPGH PGQPGPRGPP
     GLDGCNGTQG AVGFPGPDGY PGLLGPPGLP GQKGSKGDPV LAPGSFKGMK GDPGLPGLDG
     ITGPQGAPGF PGAVGPAGPP GLQGPPGPPG PLGPDGNMGL GFQGEKGVKG DVGLPGPAGP
     PPSTGELEFM GFPKGKKGSK GEPGPKGFPG ISGPPGFPGL GTTGEKGEKG EKGIPGLPGP
     RGPMGSEGVQ GPPGQQGKKG TLGFPGLNGF QGIEGQKGDI GLPGPDVFID IDGAVISGNP
     GDPGVPGLPG LKGDEGIQGL RGPSGVPGLP ALSGVPGALG PQGFPGLKGD QGNPGRTTIG
     AAGLPGRDGL PGPPGPPGPP SPEFETETLH NKESGFPGLR GEQGPKGNLG LKGIKGDSGF
     CACDGGVPNT GPPGEPGPPG PWGLIGLPGL KGARGDRGSG GAQGPAGAPG LVGPLGPSGP
     KGKKGEPILS TIQGMPGDRG DSGSQGFRGV IGEPGKDGVP GLPGLPGLPG DGGQGFPGEK
     GLPGLPGEKG HPGPPGLPGN GLPGLPGPRG LPGDKGKDGL PGQQGLPGSK GITLPCIIPG
     SYGPSGFPGT PGFPGPKGSR GLPGTPGQPG SSGSKGEPGS PGLVHLPELP GFPGPRGEKG
     LPGFPGLPGK DGLPGMIGSP GLPGSKGATG DIFGAENGAP GEQGLQGLTG HKGFLGDSGL
     PGLKGVHGKP GLLGPKGERG SPGTPGQVGQ PGTPGSSGPY GIKGKSGLPG APGFPGISGH
     PGKKGTRGKK GPPGSIVKKG LPGLKGLPGN PGLVGLKGSP GSPGVAGLPA LSGPKGEKGS
     VGFVGFPGIP GLPGIPGTRG LKGIPGSTGK MGPSGRAGTP GEKGDRGNPG PVGIPSPRRP
     MSNLWLKGDK GSQGSAGSNG FPGPRGDKGE AGRPGPPGLP GAPGLPGIIK GVSGKPGPPG
     FMGIRGLPGL KGSSGITGFP GMPGESGSQG IRGSPGLPGA SGLPGLKGDN GQTVEISGSP
     GPKGQPGESG FKGTKGRDGL IGNIGFPGNK GEDGKVGVSG DVGLPGAPGF PGVAGMRGEP
     GLPGSSGHQG AIGPLGSPGL IGPKGPSITG VPGPAGLPGP KGEKGYPGIG IGAPGKPGLR
     GQKGDRGFPG LQGPAGLPGA PGISLPSLIA GQPGDPGRPG LDGERGRPGP AGPPGPPGPS
     SNQGDTGDPG FPGIPGPKGP KGDQGIPGFS GLPGELGLKG MRGEPGFMGT PGKVGPPGDP
     GFPGMKGKAG PRGSSGLQGD PGQTPTAEAV QVPPGPLGLP GIDGIPGLTG DPGAQGPVGL
     QGSKGLPGIP GKDGPSGLPG PPGALGDPGL PGLQGPPGFE GAPGQQGPFG MPGMPGQSMR
     VGYTLVKHSQ SEQVPPCPIG MSQLWVGYSL LFVEGQEKAH NQDLGFAGSC LPRFSTMPFI
     YCNINEVCHY ARRNDKSYWL STTAPIPMMP VSQTQIPQYI SRCSVCEAPS QAIAVHSQDI
     TIPQCPLGWR SLWIGYSFLM HTAAGAEGGG QSLVSPGSCL EDFRATPFIE CSGARGTCHY
     FANKYSFWLT TVEERQQFGE LPVSETLKAG QLHTRVSRCQ VCMKSL
//